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Science 15 January 1988:
Vol. 239. no. 4837, pp. 268 - 275
DOI: 10.1126/science.3276003
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Articles

Science, Vol 239, Issue 4837, 268-275
Copyright © 1988 by American Association for the Advancement of Science

articles

Structural and functional roles of glycosyl-phosphatidylinositol in membranes

MG Low and AR Saltiel

Department of Physiology and Cellular Biophysics, College of Physicians and Surgeons of Columbia University, New York, NY 10032.

Glycosylated forms of phosphatidylinositol, which have only recently been described in eukaryotic organisms, are now known to play important roles in biological membrane function. These molecules can serve as the sole means by which particular cell-surface proteins are anchored to the membrane. Lipids with similar structures may also be involved in signal transduction mechanisms for the hormone insulin. The utilization of this novel class of lipid molecules for these two distinct functions suggests new mechanisms for the regulation of proteins in biological membranes.


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