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Science 8 January 1988:
Vol. 239. no. 4836, pp. 190 - 193
DOI: 10.1126/science.2827305
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Articles

Science, Vol 239, Issue 4836, 190-193
Copyright © 1988 by American Association for the Advancement of Science

articles

Antagonistic adrenergic-muscarinic regulation of M current in smooth muscle cells

SM Sims, JJ Singer, and JV Walsh Jr

Department of Physiology, University of Massachusetts Medical School Worcester 01655.

The beta-adrenergic agonist isoproterenol and analogs of adenosine 3',5'-monophosphate (cAMP) induced a potassium current, M current, in freshly dissociated gastric smooth muscle cells. Muscarinic agonists suppress this current, apparently by acting at a locus downstream from regulation of cAMP levels by adenylate cyclase and phosphodiesterase. Thus, M current can be induced by an agent and regulated in antagonistic fashion by beta-adrenergic and muscarinic systems.


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