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Science 1 January 1988:
Vol. 239. no. 4835, pp. 55 - 57
DOI: 10.1126/science.3336774
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Articles

Science, Vol 239, Issue 4835, 55-57
Copyright © 1988 by American Association for the Advancement of Science

articles

Implantation of Bacteroides gingivalis in nonhuman primates initiates progression of periodontitis

SC Holt, J Ebersole, J Felton, M Brunsvold, and KS Kornman

Department of Periodontics, University of Texas Health Science Center at San Antonio 78284.

Although periodontitis is a bacterial disease, its multidimensional nature and its bacterial complexity have made it difficult to definitively prove that specific microorganisms initiate the disease process. The successful implantation of a rifampin-resistant strain of the putative periodontal pathogen Bacteroides gingivalis into the periodontal microbiota of monkeys (Macaca fascicularis) resulted in an increase in the systemic levels of antibody to the microorganism and rapid and significant bone loss.


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Inhibition of Experimental Periodontitis by a Topical Boron-based Antimicrobial.
Q. Luan, T. Desta, L. Chehab, V.J. Sanders, J. Plattner, and D.T. Graves (2008)
J. Dent. Res. 87, 148-152
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Biphasic Effect of Gingipains from Porphyromonas gingivalis on the Human Complement System.
K. Popadiak, J. Potempa, K. Riesbeck, and A. M. Blom (2007)
J. Immunol. 178, 7242-7250
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Does the Importance of the C-Terminal Residues in the Maturation of RgpB from Porphyromonas gingivalis Reveal a Novel Mechanism for Protein Export in a Subgroup of Gram-Negative Bacteria?.
K.-A. Nguyen, J. Travis, and J. Potempa (2007)
J. Bacteriol. 189, 833-843
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Th1 Immune Response Promotes Severe Bone Resorption Caused by Porphyromonas gingivalis.
P. Stashenko, R. B. Goncalves, B. Lipkin, A. Ficarelli, H. Sasaki, and A. Campos-Neto (2007)
Am. J. Pathol. 170, 203-213
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The K1 Serotype Capsular Polysaccharide of Porphyromonas gingivalis Elicits Chemokine Production from Murine Macrophages That Facilitates Cell Migration.
G. d'Empaire, M. T. Baer, and F. C. Gibson III (2006)
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Gingipains from Porphyromonas gingivalis W83 Synergistically Disrupt Endothelial Cell Adhesion and Can Induce Caspase-Independent Apoptosis..
S. M. Sheets, J. Potempa, J. Travis, H. M. Fletcher, and C. A. Casiano (2006)
Infect. Immun. 74, 5667-5678
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T-Cell Expression Cloning of Porphyromonas gingivalis Genes Coding for T Helper-Biased Immune Responses during Infection.
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Infect. Immun. 74, 3958-3966
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The HA2 haemagglutinin domain of the lysine-specific gingipain (Kgp) of Porphyromonas gingivalis promotes {micro}-oxo bishaem formation from monomeric iron(III) protoporphyrin IX.
J. W. Smalley, A. J. Birss, B. Szmigielski, and J. Potempa (2006)
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Immunization Enhances Inflammation and Tissue Destruction in Response to Porphyromonas gingivalis.
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Innate Immune Signaling and Porphyromonas gingivalis-accelerated Atherosclerosis.
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J. Dent. Res. 85, 106-121
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H. A. Al-Mashat, S. Kandru, R. Liu, Y. Behl, T. Desta, and D. T. Graves (2006)
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Multilocus Sequence Typing of Porphyromonas gingivalis Strains from Different Geographic Origins.
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An Immune Response Directed to Proteinase and Adhesin Functional Epitopes Protects against Porphyromonas gingivalis-Induced Periodontal Bone Loss.
N. M. O'Brien-Simpson, R. D. Pathirana, R. A. Paolini, Y.-Y. Chen, P. D. Veith, V. Tam, N. Ally, R. N. Pike, and E. C. Reynolds (2005)
J. Immunol. 175, 3980-3989
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Porphyromonas gingivalis Fimbria-Dependent Activation of Inflammatory Genes in Human Aortic Endothelial Cells.
H.-H. Chou, H. Yumoto, M. Davey, Y. Takahashi, T. Miyamoto, F. C. Gibson III, and C. A. Genco (2005)
Infect. Immun. 73, 5367-5378
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Molecular Mechanism for Connective Tissue Destruction by Dipeptidyl Aminopeptidase IV Produced by the Periodontal Pathogen Porphyromonas gingivalis.
Y. Kumagai, H. Yagishita, A. Yajima, T. Okamoto, and K. Konishi (2005)
Infect. Immun. 73, 2655-2664
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Inflammation is More Persistent in Type 1 Diabetic Mice.
D.T. Graves, G. Naguib, H. Lu, C. Leone, H. Hsue, and E. Krall (2005)
J. Dent. Res. 84, 324-328
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A Functional Virulence Complex Composed of Gingipains, Adhesins, and Lipopolysaccharide Shows High Affinity to Host Cells and Matrix Proteins and Escapes Recognition by Host Immune Systems.
R. Takii, T. Kadowaki, A. Baba, T. Tsukuba, and K. Yamamoto (2005)
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Innate Immunity 11, 13-18
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Culture-Independent Identification of Periodontitis-Associated Porphyromonas and Tannerella Populations by Targeted Molecular Analysis.
A. de Lillo, V. Booth, L. Kyriacou, A. J. Weightman, and W. G. Wade (2004)
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Suppression of Pathogenicity of Porphyromonas gingivalis by Newly Developed Gingipain Inhibitors.
T. Kadowaki, A. Baba, N. Abe, R. Takii, M. Hashimoto, T. Tsukuba, S. Okazaki, Y. Suda, T. Asao, and K. Yamamoto (2004)
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TLR Signaling: An Emerging Bridge from Innate Immunity to Atherogenesis.
K. S. Michelsen, T. M. Doherty, P. K. Shah, and M. Arditi (2004)
J. Immunol. 173, 5901-5907
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Innate Immune Recognition of Invasive Bacteria Accelerates Atherosclerosis in Apolipoprotein E-Deficient Mice.
F. C. Gibson III, C. Hong, H.-H. Chou, H. Yumoto, J. Chen, E. Lien, J. Wong, and C. Attardo Genco (2004)
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Diabetes Alters the Response to Bacteria by Enhancing Fibroblast Apoptosis.
R. Liu, T. Desta, H. He, and D. T. Graves (2004)
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Humoral Responses to Porphyromonas gingivalis Gingipain Adhesin Domains in Subjects with Chronic Periodontitis.
K.-A. Nguyen, A. A. DeCarlo, M. Paramaesvaran, C. A. Collyer, D. B. Langley, and N. Hunter (2004)
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Mice Lacking Inducible Nitric Oxide Synthase Demonstrate Impaired Killing of Porphyromonas gingivalis.
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Role of the Phosphatidylinositol 3 Kinase-Akt Pathway in the Regulation of IL-10 and IL-12 by Porphyromonas gingivalis Lipopolysaccharide.
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Fimbria-Dependent Activation of Cell Adhesion Molecule Expression in Porphyromonas gingivalis-Infected Endothelial Cells.
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Infect. Immun. 70, 257-267
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Histopathological Studies on Virulence of Dipeptidyl Aminopeptidase IV (DPPIV) of Porphyromonasgingivalis in a Mouse Abscess Model: Use of a DPPIV-Deficient Mutant.
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Infect. Immun. 69, 7159-7161
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Arginine-Specific Protease from Porphyromonas gingivalis Activates Protease-Activated Receptors on Human Oral Epithelial Cells and Induces Interleukin-6 Secretion.
A. Lourbakos, J. Potempa, J. Travis, M. R. D'Andrea, P. Andrade-Gordon, R. Santulli, E. J. Mackie, and R. N. Pike (2001)
Infect. Immun. 69, 5121-5130
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Evidence of Recombination in Porphyromonas gingivalis and Random Distribution of Putative Virulence Markers.
E. V. G. Frandsen, K. Poulsen, M. A. Curtis, and M. Kilian (2001)
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I. Rubinstein, J. Potempa, J. Travis, and X.-P. Gao (2001)
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Characterization of a Novel Outer Membrane Hemin-Binding Protein of Porphyromonas gingivalis.
S. G. Dashper, A. Hendtlass, N. Slakeski, C. Jackson, K. J. Cross, L. Brownfield, R. Hamilton, I. Barr, and E. C. Reynolds (2000)
J. Bacteriol. 182, 6456-6462
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Generation of Lys-gingipain protease activity in Porphyromonas gingivalis W50 is independent of Arg-gingipain protease activities.
J. Aduse-Opoku, N. N. Davies, A. Gallagher, A. Hashim, H. E. A. Evans, M. Rangarajan, J. M. Slaney, and M. A. Curtis (2000)
Microbiology 146, 1933-1940
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RgpA-Kgp Peptide-Based Immunogens Provide Protection against Porphyromonas gingivalis Challenge in a Murine Lesion Model.
N. M. O'Brien-Simpson, R. A. Paolini, and E. C. Reynolds (2000)
Infect. Immun. 68, 4055-4063
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Enzymatic Properties of Dipeptidyl Aminopeptidase IV Produced by the Periodontal Pathogen Porphyromonas gingivalis and Its Participation in Virulence.
Y. Kumagai, K. Konishi, T. Gomi, H. Yagishita, A. Yajima, and M. Yoshikawa (2000)
Infect. Immun. 68, 716-724
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Purification, Characterization, and Sequence Analysis of a Potential Virulence Factor from Porphyromonas gingivalis, Peptidylarginine Deiminase.
W. T. McGraw, J. Potempa, D. Farley, and J. Travis (1999)
Infect. Immun. 67, 3248-3256
   Abstract »    Full Text »    PDF »
Modulation of Major Histocompatibility Complex Protein Expression by Human Gamma Interferon Mediated by Cysteine Proteinase-Adhesin Polyproteins of Porphyromonas gingivalis.
P. L. W. Yun, A. A. DeCarlo, and N. Hunter (1999)
Infect. Immun. 67, 2986-2995
   Abstract »    Full Text »    PDF »
Transformation and Expression of a Cloned fimA Gene in Porphyromonas gingivalis.
Y. Takahashi, D. Kato, N. Hamada, H. Yoshimoto, and T. Umemoto (1999)
Infect. Immun. 67, 2013-2018
   Abstract »    Full Text »    PDF »
Bone Resorption Caused by Three Periodontal Pathogens In Vivo in Mice Is Mediated in Part by Prostaglandin.
Y. Zubery, C. R. Dunstan, B. M. Story, L. Kesavalu, J. L. Ebersole, S. C. Holt, and B. F. Boyce (1998)
Infect. Immun. 66, 4158-4162
   Abstract »    Full Text »    PDF »
Construction of a Functional Single-Chain Variable Fragment Antibody against Hemagglutinin from Porphyromonas gingivalis.
Y. Shibata, K. Kurihara, H. Takiguchi, and Y. Abiko (1998)
Infect. Immun. 66, 2207-2212
   Abstract »    Full Text »    PDF »
Local Chemokine Paralysis, a Novel Pathogenic Mechanism for Porphyromonas gingivalis.
R. P. Darveau, C. M. Belton, R. A. Reife, and R. J. Lamont (1998)
Infect. Immun. 66, 1660-1665
   Abstract »    Full Text »    PDF »
IL-1 and TNF Antagonists Inhibit the Inflammatory Response and Bone Loss in Experimental Periodontitis.
R. Assuma, T. Oates, D. Cochran, S. Amar, and D. T. Graves (1998)
J. Immunol. 160, 403-409
   Abstract »    Full Text »    PDF »
Molecular Cloning and Characterization of Porphyromonas gingivalis Lysine-specific Gingipain. A NEW MEMBER OF AN EMERGING FAMILY OF PATHOGENIC BACTERIAL CYSTEINE PROTEINASES.
N. Pavloff, P. A. Pemberton, J. Potempa, W.-C. A. Chen, R. N. Pike, V. Prochazka, M. C. Kiefer, J. Travis, and P. J. Barr (1997)
J. Biol. Chem. 272, 1595-1600
   Abstract »    Full Text »    PDF »


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Science. ISSN 0036-8075 (print), 1095-9203 (online)