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Science 18 December 1987:
Vol. 238. no. 4834, pp. 1707 - 1709
DOI: 10.1126/science.3500515
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Articles

Science, Vol 238, Issue 4834, 1707-1709
Copyright © 1987 by American Association for the Advancement of Science

articles

Three-dimensional structure of interleukin-2

BJ Brandhuber, T Boone, WC Kenney, and DB McKay

Department of Chemistry and Biochemistry, University of Colorado, Boulder 80309.

Interleukin-2 is an effector protein that participates in modulating the immune response; it has become a focal point for the study of lymphokine structure and function. The three-dimensional structure of the interleukin molecule has been solved to 3.0 angstrom resolution. Interleukin-2 has a novel alpha-helical tertiary structure that suggests one portion of the molecule forms a structural scaffold, which underlies the receptor binding facets of the molecule.


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