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Science 18 December 1987:
Vol. 238. no. 4834, pp. 1675 - 1681
DOI: 10.1126/science.3686007

Articles

Science, Vol 238, Issue 4834, 1675-1681
Copyright © 1987 by American Association for the Advancement of Science


articles

Determination of anteroposterior polarity in Drosophila

C Nusslein-Volhard, HG Frohnhofer, and R Lehmann

Max-Planck-Institut fur Entwicklungsbiologie, Tubingen, Federal Republic of Germany.

The principles of pattern formation in embryogenesis can be studied in Drosophila by means of a powerful combination of genetic and transplantation experiments. The segmented pattern of the Drosophila embryo is organized by two activities localized at the anterior and posterior egg poles. Both activities exert inducing and polarizing effects on the pattern when transplanted to other egg regions. A small set of maternal genes have been identified that are required for these activities. Mutants in these genes lack either the anterior or posterior part of the segmented pattern. The unsegmented terminal embryonic regions require a third class of genes and form independently of the anterior and posterior centers.


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Science. ISSN 0036-8075 (print), 1095-9203 (online)