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Science 11 December 1987:
Vol. 238. no. 4833, pp. 1545 - 1550
DOI: 10.1126/science.3685992
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Articles

Science, Vol 238, Issue 4833, 1545-1550
Copyright © 1987 by American Association for the Advancement of Science

articles

Reading frame selection and transfer RNA anticodon loop stacking

JF Curran and M Yarus

Department of Molecular, Cellular, and Developmental Biology, University of Colorado, Boulder 80309.

Messenger RNA's are translated in successive three-nucleotide steps (a reading frame), therefore decoding must proceed in only one of three possible frames. A molecular model for correct propagation of the frame is presented based on (i) the measured translational properties of transfer RNA's (tRNA's) that contain an extra nucleotide in the anticodon loop and (ii) a straightforward concept about anticodon loop structure. The model explains the high accuracy of reading frame maintenance by normal tRNA's, as well as activities of all characterized frameshift suppressor tRNA's that have altered anticodon loops.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Anticodon loop mutations perturb reading frame maintenance by the E site tRNA.
C. L. Sanders, K. J. Lohr, H. L. Gambill, R. B. Curran, and J. F. Curran (2008)
RNA 14, 1874-1881
   Abstract »    Full Text »    PDF »
Genetic analysis of the E site during RF2 programmed frameshifting.
C. L. Sanders and J. F. Curran (2007)
RNA 13, 1483-1491
   Abstract »    Full Text »    PDF »
Structures of tRNAs with an expanded anticodon loop in the decoding center of the 30S ribosomal subunit.
C. M. Dunham, M. Selmer, S. S. Phelps, A. C. Kelley, T. Suzuki, S. Joseph, and V. Ramakrishnan (2007)
RNA 13, 817-823
   Abstract »    Full Text »    PDF »
An expanded genetic code with a functional quadruplet codon.
J. C. Anderson, N. Wu, S. W. Santoro, V. Lakshman, D. S. King, and P. G. Schultz (2004)
PNAS 101, 7566-7571
   Abstract »    Full Text »    PDF »
Yeast Frameshift Suppressor Mutations in the Genes Coding for Transcription Factor Mbf1p and Ribosomal Protein S3: Evidence for Autoregulation of S3 Synthesis.
J. L. Hendrick, P. G. Wilson, I. I. Edelman, M. G. Sandbaken, D. Ursic, and M. R. Culbertson (2001)
Genetics 157, 1141-1158
   Abstract »    Full Text »
Decoding of tandem quadruplets by adjacent tRNAs with eight-base anticodon loops.
B. Moore, C. C. Nelson, B. C. Persson, R. F. Gesteland, and J. F. Atkins (2000)
Nucleic Acids Res. 28, 3615-3624
   Abstract »    Full Text »    PDF »


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Science. ISSN 0036-8075 (print), 1095-9203 (online)