Related Content
Search Google Scholar for:
|
|
Science 11 December 1987:
Vol. 238. no. 4833, pp. 1539 - 1545
DOI: 10.1126/science.3317834
|
|
Articles
Science, Vol 238, Issue 4833, 1539-1545
Copyright © 1987 by American Association for the Advancement of Science
The approaching era of the tumor suppressor genes
G Klein
Department of Tumor Biology, Karolinska Institutet, Stockholm, Sweden.
Genes that can inhibit the expression of the tumorigenic phenotype have been detected by the fusion of normal and malignant cells, the phenotypic reversion of in vitro transformants, the induction of terminal differentiation of malignant cell lineages, the loss of "recessive cancer genes," the discovery of regulatory sequences in the immediate vicinity of certain oncogenes, and the inhibition of tumor growth by normal cell products. Such tumor suppressor genes will probably turn out to be as, if not more, diversified as the oncogenes. Consideration of both kinds of genes may reveal common or interrelated functional properties.
THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
- Sustained Production of H2O2 Activates Pro-matrix Metalloproteinase-2 through Receptor Tyrosine Kinases/Phosphatidylinositol 3-Kinase/NF-kappa B Pathway.
- S.-O. Yoon, S.-J. Park, S. Y. Yoon, C.-H. Yun, and A.-S. Chung (2002)
J. Biol. Chem.
277, 30271-30282
| Abstract »
| Full Text »
| PDF »
- Recent Advances in Genetics, Diagnosis, Localization, and Treatment of Pheochromocytoma.
- K. Pacak, W. M. Linehan, G. Eisenhofer, M. M. Walther, and D. S. Goldstein (2001)
Ann Intern Med
134, 315-329
| Abstract »
| Full Text »
| PDF »
- Reciprocal Regulation of Adipogenesis by Myc and C/EBPagr.
- S. O. Freytag and T. J. Geddes (1992)
Science
256, 379-382
| Abstract »
| PDF »
- Tumor suppressor genes.
- R. Weinberg (1991)
Science
254, 1138-1146
| Abstract »
| PDF »
- A genetic tool used to identify thioredoxin as a mediator of a growth inhibitory signal.
- L. Deiss and A Kimchi (1991)
Science
252, 117-120
| Abstract »
| PDF »
- Replicative senescence: the human fibroblast comes of age.
- S Goldstein (1990)
Science
249, 1129-1133
| Abstract »
| PDF »
- Identification of small clusters of divergent amino acids that mediate the opposing effects of ras and Krev-1.
- K Zhang, M Noda, W. Vass, A. Papageorge, and D. Lowy (1990)
Science
249, 162-165
| Abstract »
| PDF »
- Suppression of tumorigenicity of human prostate carcinoma cells by replacing a mutated RB gene.
- R Bookstein, J. Shew, P. Chen, P Scully, and W. Lee (1990)
Science
247, 712-715
| Abstract »
| PDF »
- Tumorigenicity in human melanoma cell lines controlled by introduction of human chromosome 6.
- J. Trent, E. Stanbridge, H. McBride, E. Meese, G Casey, D. Araujo, C. Witkowski, and R. Nagle (1990)
Science
247, 568-571
| Abstract »
| PDF »
- Tumor suppressor genes: the puzzle and the promise.
- R Sager (1989)
Science
246, 1406-1412
| Abstract »
| PDF »
- Transgenic mice as probes into complex systems.
- D Hanahan (1989)
Science
246, 1265-1275
| Abstract »
| PDF »
- G1 events and regulation of cell proliferation.
- A. Pardee (1989)
Science
246, 603-608
| Abstract »
| PDF »
- Suppression of the neoplastic phenotype by replacement of the RB gene in human cancer cells.
- H. Huang, J. Yee, J. Shew, P. Chen, R Bookstein, T Friedmann, E. Lee, and W. Lee (1988)
Science
242, 1563-1566
| Abstract »
| PDF »
- DNA diagnostics--molecular techniques and automation.
- U Landegren, R Kaiser, C. Caskey, and L Hood (1988)
Science
242, 229-237
| Abstract »
| PDF »
- Site-specific integration of H-ras in transformed rat embryo cells.
- W. McKenna, K Nakahara, and R. Muschel (1988)
Science
241, 1325-1328
| Abstract »
| PDF »
- Abnormalities in structure and expression of the human retinoblastoma gene in SCLC.
- J. Harbour, S. Lai, J Whang-Peng, A. Gazdar, J. Minna, and F. Kaye (1988)
Science
241, 353-357
| Abstract »
| PDF »
- Inactivation of the retinoblastoma susceptibility gene in human breast cancers.
- E. Lee, H To, J. Shew, R Bookstein, P Scully, and W. Lee (1988)
Science
241, 218-221
| Abstract »
| PDF »
|
|
