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Science 4 December 1987:
Vol. 238. no. 4832, pp. 1411 - 1413
DOI: 10.1126/science.3479843
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Articles

Science, Vol 238, Issue 4832, 1411-1413
Copyright © 1987 by American Association for the Advancement of Science

articles

The gene for familial polyposis coli maps to the long arm of chromosome 5

M Leppert, M Dobbs, P Scambler, P O'Connell, Y Nakamura, D Stauffer, S Woodward, R Burt, J Hughes, E Gardner, and al. et

Howard Hughes Medical Institute, Department of Human Genetics, University of Utah Medical Center, Salt Lake City 84132.

The inherited genetic defect in adenomatous polyposis has been localized to a small region on the long arm of chromosome 5. Sixteen DNA marker loci were used to construct a linkage map of the chromosome. When five kindreds segregating a gene for adenomatous polyposis coli were characterized with a number of the markers, significant linkage was found between one marker and the disease gene. Linkage analysis determined the location of the defective gene within a primary genetic map of chromosome 5.


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