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Science 27 November 1987:
Vol. 238. no. 4831, pp. 1272 - 1275
DOI: 10.1126/science.3685977
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Articles
Science, Vol 238, Issue 4831, 1272-1275
Copyright © 1987 by American Association for the Advancement of Science
Mutations in the first exon are associated with altered transcription of c-myc in Burkitt lymphoma
E Cesarman,
R Dalla-Favera,
D Bentley,
and
M Groudine
Department of Pathology, New York University School of Medicine, NY 10016.
The c-myc proto-oncogene is involved in chromosomal translocations that are specifically and consistently found in Burkitt lymphoma. Although these translocations are thought to lead to a deregulation of c-myc expression, the structural and functional basis of this phenomenon has not been identified. Mutations in a specific region spanning approximately 70 base pairs and located at the 3' border of the first exon of translocated c-myc alleles were consistently detected in Burkitt lymphoma cells carrying classic (8:14) as well as variant (8:22 and 2:8) translocations. These structural alterations were accompanied by an altered pattern of c-myc transcription, namely, the removal of a block to transcriptional elongation that has been mapped to the same region. Thus, specific c-myc mutations leading to the alleviation of this block to transcriptional elongation may represent a general mechanism causing c-myc activation in Burkitt lymphoma.
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