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Science 27 November 1987:
Vol. 238. no. 4831, pp. 1269 - 1271
DOI: 10.1126/science.3685976
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Articles

Science, Vol 238, Issue 4831, 1269-1271
Copyright © 1987 by American Association for the Advancement of Science

articles

A cell-cycle constraint on the regulation of gene expression by platelet-derived growth factor

BJ Rollins, ED Morrison, and CD Stiles

Division of Medicine, Dana-Farber Cancer Institute, Boston, MA 02115.

In density-arrested monolayer cultures of Balb/c 3T3 cells, platelet-derived growth factor (PDGF) stimulates expression of the c-myc and c-fos proto-oncogenes, as well as the functionally uncharacterized genes, JE, KC, and JB. These genes are not coordinately regulated. Under ordinary conditions, c-fos, JE, KC, and JB respond to PDGF only when the cells are in a state of G0 growth arrest at the time of PDGF addition. The c-myc gene is regulated in opposition to the other genes, responding best to PDGF in cycling cultures.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Platelet-Derived Growth Factor-Stimulated Expression of the MCP-1 Immediate-Early Gene Involves an Inhibitory Multiprotein Complex.
P. Sridhar, Y. Liu, L. D. Chin, C. E. Borja, M. Mann, H. A. Skopicki, and R. R. Freter (1999)
Mol. Cell. Biol. 19, 4219-4230
   Abstract »    Full Text »    PDF »
Expression of the Aryl Hydrocarbon Receptor Is Regulated by Serum and Mitogenic Growth Factors in Murine 3T3 Fibroblasts.
C. Vaziri, A. Schneider, D. H. Sherr, and D. V. Faller (1996)
J. Biol. Chem. 271, 25921-25927
   Abstract »    Full Text »    PDF »
Platelet-derived Growth Factor Induction of the Immediate-early gene MCP-1 Is Mediated by NF-kappa B and a 90-kDa Phosphoprotein Coactivator.
R. R. Freter, J. A. Alberta, G. Y. Hwang, A. L. Wrentmore, and C. D. Stiles (1996)
J. Biol. Chem. 271, 17417-17424
   Abstract »    Full Text »    PDF »
The c-fos serum response element responds to protein kinase C-dependent and -independent signals but not to cyclic AMP..
M Z Gilman (1988)
Genes & Dev. 2, 394-402
   Abstract »    PDF »


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Science. ISSN 0036-8075 (print), 1095-9203 (online)