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Science 20 November 1987:
Vol. 238. no. 4830, pp. 1144 - 1146
DOI: 10.1126/science.3500512
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Articles

Science, Vol 238, Issue 4830, 1144-1146
Copyright © 1987 by American Association for the Advancement of Science

articles

Lymphotoxin is an important T cell-derived growth factor for human B cells

JH Kehrl, M Alvarez-Mon, GA Delsing, and AS Fauci

Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892.

Two different assays for B cell growth factors (BCGF) and an antibody against lymphotoxin were used to show that the presence of lymphotoxin in conditioned media derived from normal activated T cells and in a partially purified BCGF accounts for a substantial portion of their B cell growth-promoting activity. A competitive binding assay confirmed the presence of significant amounts of lymphotoxin in the partially purified BCGF. Recombinant lymphotoxin enhanced the proliferation of activated B cells and augmented B cell proliferation and immunoglobulin secretion induced by interleukin-2.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Survival and Clonal Expansion of Mutating "Forbidden" (Immunoglobulin Receptor-deficient) Epstein-Barr Virus-infected B Cells in Angioimmunoblastic T Cell Lymphoma.
A. Brauninger, T. Spieker, K. Willenbrock, P. Gaulard, H.-H. Wacker, K. Rajewsky, M.-L. Hansmann, and R. Kuppers (2001)
J. Exp. Med. 194, 927-940
   Abstract »    Full Text »    PDF »
TNFA and TNFB Polymorphisms in Myasthenia Gravis.
G. O. Skeie, J. P. Pandey, J. A. Aarli, and N. E. Gilhus (1999)
Arch Neurol 56, 457-461
   Abstract »    Full Text »    PDF »
Naive Human CD4+ T Cells Are a Major Source of Lymphotoxin {alpha}.
Y. Ohshima, L-P. Yang, M-N. Avice, M. Kurimoto, T. Nakajima, M. Sergerie, C. E. Demeure, M. Sarfati, and G. Delespesse (1999)
J. Immunol. 162, 3790-3794
   Abstract »    Full Text »    PDF »
TRANCE Is a Novel Ligand of the Tumor Necrosis Factor Receptor Family That Activates c-Jun N-terminal Kinase in T Cells.
B. R. Wong, J. Rho, J. Arron, E. Robinson, J. Orlinick, M. Chao, S. Kalachikov, E. Cayani, F. S. Bartlett III, W. N. Frankel, et al. (1997)
J. Biol. Chem. 272, 25190-25194
   Abstract »    Full Text »    PDF »
Abnormal development of secondary lymphoid tissues in lymphotoxin beta -deficient mice.
M. B. Alimzhanov, D. V. Kuprash, M. H. Kosco-Vilbois, A. Luz, R. L. Turetskaya, A. Tarakhovsky, K. Rajewsky, S. A. Nedospasov, and K. Pfeffer (1997)
PNAS 94, 9302-9307
   Abstract »    Full Text »    PDF »
Regulation of endotoxin mitogenicity in murine spleen cells by tumor necrosis factor {alpha}.
D.M. Jakobs and F.U. Schade (1994)
Innate Immunity 1, 175-179
   Abstract »    PDF »
Abnormal development of peripheral lymphoid organs in mice deficient in lymphotoxin.
P De Togni, J Goellner, N. Ruddle, P. Streeter, A Fick, S Mariathasan, S. Smith, R Carlson, L. Shornick, J Strauss-Schoenberger, et al. (1994)
Science 264, 703-707
   Abstract »    PDF »


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