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Science 20 November 1987: Vol. 238. no. 4830, pp. 1132 - 1134 DOI: 10.1126/science.2961059
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Articles
Science, Vol 238, Issue 4830, 1132-1134
Copyright © 1987 by American Association for the Advancement of Science
YIGSR, a synthetic laminin pentapeptide, inhibits experimental metastasis formation
Y Iwamoto,
FA Robey,
J Graf,
M Sasaki,
HK Kleinman,
Y Yamada,
and
GR Martin
Laboratory of Developmental Biology and Anomalies, National Institute of Drug Research, Bethesda, MD 20892.
The invasion of tumor cells through basement membranes is a critical step in the formation of metastases. The binding of the malignant cells to laminin in the basement membranes allows their attachment and activates their invasiveness. Recently a synthetic nonapeptide from the B1 chain sequence of laminin was identified as a major site for cell binding. A pentapeptide within the nonapeptide sequence was found to reduce the formation of lung colonies in mice injected with melanoma cells and also to inhibit the invasiveness of the cells in vitro.
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