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Science 20 November 1987:
Vol. 238. no. 4830, pp. 1094 - 1098
DOI: 10.1126/science.3317827
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Articles

Science, Vol 238, Issue 4830, 1094-1098
Copyright © 1987 by American Association for the Advancement of Science

articles

The chicken B cell compartment

JC Weill and CA Reynaud

Institut Jacques Monod, CNRS, Universite Paris, France.

A very unusual molecular mechanism is involved in generating the preimmune repertoire in the chicken bursa of Fabricius. A unique rearranged V gene is diversified through a program of segmental gene conversion with a pool of noncoding pseudogenes being used as donors. A specifically committed progenitor that originates in the embryonic bursa is responsible for long-term maintenance of the B cell population. Both these properties and the characteristics of the peripheral B cell compartment are discussed in terms of the evolution of the T and B immune systems.


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