Science 20 November 1987: Vol. 238. no. 4830, pp. 1079 - 1087 DOI: 10.1126/science.3317825

Prev | Table of Contents | Next

Articles

Transcription-associated recombination in eukaryotes: link between transcription, replication and recombination.

P. Gottipati and T. Helleday (2009)
Mutagenesis 24, 203-210
 |  Abstract »  |  Full Text »  |  PDF »

A Role for DNA Polymerase {micro} in the Emerging DJH Rearrangements of the Postgastrulation Mouse Embryo.

B. Gozalbo-Lopez, P. Andrade, G. Terrados, B. de Andres, N. Serrano, I. Cortegano, B. Palacios, A. Bernad, L. Blanco, M. A. R. Marcos, et al. (2009)
Mol. Cell. Biol. 29, 1266-1275
 |  Abstract »  |  Full Text »  |  PDF »

Closely related antibody receptors exploit fundamentally different strategies for steroid recognition.

P. Verdino, C. Aldag, D. Hilvert, and I. A. Wilson (2008)
PNAS 105, 11725-11730
 |  Abstract »  |  Full Text »  |  PDF »

Sheepish B cells: evidence for antigen-independent antibody diversification in humans and mice.

D. Tarlinton (2008)
J. Exp. Med. 205, 1251-1254
 |  Abstract »  |  Full Text »  |  PDF »

Porcine Reproductive and Respiratory Syndrome Virus Subverts Repertoire Development by Proliferation of Germline-Encoded B Cells of All Isotypes Bearing Hydrophobic Heavy Chain CDR3.

J. E. Butler, N. Wertz, P. Weber, and K. M. Lager (2008)
J. Immunol. 180, 2347-2356
 |  Abstract »  |  Full Text »  |  PDF »

Phospholipase C{gamma}2 Contributes to Light-Chain Gene Activation and Receptor Editing.

L. Bai, Y. Chen, Y. He, X. Dai, X. Lin, R. Wen, and D. Wang (2007)
Mol. Cell. Biol. 27, 5957-5967
 |  Abstract »  |  Full Text »  |  PDF »

Pre-B Cell Receptor Assesses the Quality of IgH Chains and Tunes the Pre-B Cell Repertoire by Delivering Differential Signals.

Y. Kawano, S. Yoshikawa, Y. Minegishi, and H. Karasuyama (2006)
J. Immunol. 177, 2242-2249
 |  Abstract »  |  Full Text »  |  PDF »

Critical roles of the immunoglobulin intronic enhancers in maintaining the sequential rearrangement of IgH and Igk loci.

M. A. Inlay, T. Lin, H. H. Gao, and Y. Xu (2006)
J. Exp. Med. 203, 1721-1732
 |  Abstract »  |  Full Text »  |  PDF »

TCR trans-Rearrangements: Biological Significance in Antigen Recognition vs the Role as Lymphoma Biomarker.

A. Allam and D. Kabelitz (2006)
J. Immunol. 176, 5707-5712
 |  Abstract »  |  Full Text »  |  PDF »

Sequence Transfers between Variable Regions in a Mouse Antibody Transgene Can Occur by Gene Conversion.

N. D'Avirro, D. Truong, B. Xu, and E. Selsing (2005)
J. Immunol. 175, 8133-8137
 |  Abstract »  |  Full Text »  |  PDF »

In Vivo Assessment of the Relative Contributions of Deletion, Anergy, and Editing to B Cell Self-Tolerance.

K. L. Hippen, B. R. Schram, L. E. Tze, K. A. Pape, M. K. Jenkins, and T. W. Behrens (2005)
J. Immunol. 175, 909-916
 |  Abstract »  |  Full Text »  |  PDF »

Intestinal {gamma}{delta} T Cells Develop in Mice Lacking Thymus, All Lymph Nodes, Peyer's Patches, and Isolated Lymphoid Follicles.

S. Nonaka, T. Naito, H. Chen, M. Yamamoto, K. Moro, H. Kiyono, H. Hamada, and H. Ishikawa (2005)
J. Immunol. 174, 1906-1912
 |  Abstract »  |  Full Text »  |  PDF »

Cis-acting regulatory sequences promote high-frequency gene conversion between repeated sequences in mammalian cells.

S. J. Raynard and M. D. Baker (2004)
Nucleic Acids Res. 32, 5916-5927
 |  Abstract »  |  Full Text »  |  PDF »

Specificity-Based Negative Selection of Autoreactive B Cells during Memory Formation.

H. M. Guay, L. Panarey, A. J. Reed, and A. J. Caton (2004)
J. Immunol. 173, 5485-5494
 |  Abstract »  |  Full Text »  |  PDF »

The T-Cell Receptor {beta} Variable Gene Promoter Is Required for Efficient V{beta} Rearrangement but Not Allelic Exclusion.

C. J. Ryu, B. B. Haines, H. R. Lee, Y. H. Kang, D. D. Draganov, M. Lee, C. E. Whitehurst, H. J. Hong, and J. Chen (2004)
Mol. Cell. Biol. 24, 7015-7023
 |  Abstract »  |  Full Text »  |  PDF »

Duplicated copies of the bovine JH locus contribute to the Ig repertoire.

A. Hosseini, G. Campbell, M. Prorocic, and R. Aitken (2004)
Int. Immunol. 16, 843-852
 |  Abstract »  |  Full Text »  |  PDF »

Macrophages and Stromal Cells Phagocytose Apoptotic Bone Marrow-Derived B Lineage Cells.

Z. Dogusan, E. Montecino-Rodriguez, and K. Dorshkind (2004)
J. Immunol. 172, 4717-4723
 |  Abstract »  |  Full Text »  |  PDF »

Recombinogenic Phenotype of Human Activation-Induced Cytosine Deaminase.

V. P. Poltoratsky, S. H. Wilson, T. A. Kunkel, and Y. I. Pavlov (2004)
J. Immunol. 172, 4308-4313
 |  Abstract »  |  Full Text »  |  PDF »

The T cell receptor {beta} enhancer promotes access and pairing of D{beta} and J{beta} gene segments during V(D)J recombination.

C. J. Ryu, B. B. Haines, D. D. Draganov, Y. H. Kang, C. E. Whitehurst, T. Schmidt, H. J. Hong, and J. Chen (2003)
PNAS 100, 13465-13470
 |  Abstract »  |  Full Text »  |  PDF »

Microarray Profiling of Antibody Responses against Simian-Human Immunodeficiency Virus: Postchallenge Convergence of Reactivities Independent of Host Histocompatibility Type and Vaccine Regimen.

H. E. Neuman de Vegvar, R. R. Amara, L. Steinman, P. J. Utz, H. L. Robinson, and W. H. Robinson (2003)
J. Virol. 77, 11125-11138
 |  Abstract »  |  Full Text »  |  PDF »

Late Immature B Cells (IgMhighIgDneg) Undergo a Light Chain Receptor Editing Response to Soluble Self-Antigen.

L. E. Tze, K. L. Hippen, and T. W. Behrens (2003)
J. Immunol. 171, 678-682
 |  Abstract »  |  Full Text »  |  PDF »

Immunoglobulin Light Chains Dictate Vesicular Transport-dependent and -independent Routes for IgM Degradation by the Ubiquitin-Proteasome Pathway.

Y. Elkabetz, A. Kerem, L. Tencer, D. Winitz, R. R. Kopito, and S. Bar-Nun (2003)
J. Biol. Chem. 278, 18922-18929
 |  Abstract »  |  Full Text »  |  PDF »

A New Model of Sheep Ig Diversification: Shifting the Emphasis Toward Combinatorial Mechanisms and Away from Hypermutation.

C. N. Jenne, L. J. Kennedy, P. McCullagh, and J. D. Reynolds (2003)
J. Immunol. 170, 3739-3750
 |  Abstract »  |  Full Text »  |  PDF »

Minimal Residual Disease Tests Provide an Independent Predictor of Clinical Outcome in Adult Acute Lymphoblastic Leukemia.

F. Y. Mortuza, M. Papaioannou, I. M. Moreira, L. A. Coyle, P. Gameiro, D. Gandini, H. G. Prentice, A. Goldstone, A. V. Hoffbrand, and L. Foroni (2002)
J. Clin. Oncol. 20, 1094-1104
 |  Abstract »  |  Full Text »  |  PDF »

The Cleavage Efficiency of the Human Immunoglobulin Heavy Chain VH Elements by the RAG Complex. IMPLICATIONS FOR THE IMMUNE REPERTOIRE.

K. Yu, A. Taghva, and M. R. Lieber (2002)
J. Biol. Chem. 277, 5040-5046
 |  Abstract »  |  Full Text »  |  PDF »

Gene conversion-like sequence transfers in a mouse antibody transgene: antigen selection allows sensitive detection of V region interactions based on homology.

H.-F. Tsai, N. D'Avirro, and E. Selsing (2002)
Int. Immunol. 14, 55-64
 |  Abstract »  |  Full Text »  |  PDF »

Distinct Control of the Frequency and Allelic Exclusion of the V{beta} Gene Rearrangement at the TCR{beta} Locus.

P. Sieh and J. Chen (2001)
J. Immunol. 167, 2121-2129
 |  Abstract »  |  Full Text »  |  PDF »

Induction of Germline Transcription in the Human TCR{{gamma}} Locus by STAT5.

H.-C. Lee, S.-K. Ye, T. Honjo, and K. Ikuta (2001)
J. Immunol. 167, 320-326
 |  Abstract »  |  Full Text »  |  PDF »

Bruton's Tyrosine Kinase Regulates the Activation of Gene Rearrangements at the {lambda} Light Chain Locus in Precursor B Cells in the Mouse.

G. M. Dingjan, S. Middendorp, K. Dahlenborg, A. Maas, F. Grosveld, and R. W. Hendriks (2001)
J. Exp. Med. 193, 1169-1178
 |  Abstract »  |  Full Text »  |  PDF »

Definition of a Novel Cellular Constituent of the Bone Marrow That Regulates the Response of Immature B Cells to B Cell Antigen Receptor Engagement.

P. C. Sandel, M. Gendelman, G. Kelsoe, and J. G. Monroe (2001)
J. Immunol. 166, 5935-5944
 |  Abstract »  |  Full Text »  |  PDF »

Immunoglobulin heavy-chain gene rearrangement in adult acute lymphoblastic leukemia reveals preferential usage of JH-proximal variable gene segments.

F. Y. Mortuza, I. M. Moreira, M. Papaioannou, P. Gameiro, L. A. Coyle, C. S. Gricks, P. Amlot, H. G. Prentice, A. Madrigal, A. V. Hoffbrand, et al. (2001)
Blood 97, 2716-2726
 |  Abstract »  |  Full Text »  |  PDF »

Insertion of Phosphoglycerine Kinase (PGK)-Neo 5' of J{{lambda}}1 Dramatically Enhances VJ{{lambda}}1 Rearrangement.

T. Sun and U. Storb (2001)
J. Exp. Med. 193, 699-712
 |  Abstract »  |  Full Text »  |  PDF »

Immunoglobulin {beta} Signaling Regulates Locus Accessibility for Ordered Immunoglobulin Gene Rearrangements.

K. Maki, K. Nagata, F. Kitamura, T. Takemori, and H. Karasuyama (2000)
J. Exp. Med. 191, 1333-1340
 |  Abstract »  |  Full Text »  |  PDF »

Autoreactive B Cells Escape Clonal Deletion by Expressing Multiple Antigen Receptors.

J. J. Kenny, L. J. Rezanka, A. Lustig, R. T. Fischer, J. Yoder, S. Marshall, and D. L. Longo (2000)
J. Immunol. 164, 4111-4119
 |  Abstract »  |  Full Text »  |  PDF »

Antigen-Induced Somatic Diversification of Rabbit IgH Genes: Gene Conversion and Point Mutation.

C. R. Winstead, S.-K. Zhai, P. Sethupathi, and K. L. Knight (1999)
J. Immunol. 162, 6602-6612
 |  Abstract »  |  Full Text »  |  PDF »

Extended Duration of DH-JH Rearrangement in Immunoglobulin Heavy Chain Transgenic Mice: Implications for Regulation of Allelic Exclusion.

Y. Chang, M. J. Bosma, and G. C. Bosma (1999)
J. Exp. Med. 189, 1295-1305
 |  Abstract »  |  Full Text »  |  PDF »

Extensive Junctional Diversity in Ig Light Chain Genes from Early B Cell Progenitors of {micro}MT Mice.

L. A. Bentolila, S. Olson, A. Marshall, F. Rougeon, C. J. Paige, N. Doyen, and G. E. Wu (1999)
J. Immunol. 162, 2123-2128
 |  Abstract »  |  Full Text »  |  PDF »

Light Chain Shifting: Identification of a Human Plasma Cell Line Actively Undergoing Light Chain Replacement.

H. Tachibana, H. Haruta, and K. Yamada (1999)
Blood 93, 198-207
 |  Abstract »  |  Full Text »  |  PDF »

Multiple Sites of V{lambda} Diversification in Cattle.

M. R. Lucier, R. E. Thompson, J. Waire, A. W. Lin, B. A. Osborne, and R. A. Goldsby (1998)
J. Immunol. 161, 5438-5444
 |  Abstract »  |  Full Text »  |  PDF »

Evidence that Immunoglobulin VH-DJ Recombination Does Not Require Germ Line Transcription of the Recombining Variable Gene Segment.

C. Angelin-Duclos and K. Calame (1998)
Mol. Cell. Biol. 18, 6253-6264
 |  Abstract »  |  Full Text »

Differential Usage of VH Gene Segments Is Mediated by cis Elements.

C. C. K. Yu, M. Larijani, I. N. Miljanic, and G. E. Wu (1998)
J. Immunol. 161, 3444-3454
 |  Abstract »  |  Full Text »  |  PDF »

Asymmetric Contribution to Ig Repertoire Diversity by V{kappa} Exons: Differences in the Utilization of V{kappa}10 Exons.

S. P. Fitzsimmons, B. T. Rotz, and M. A. Shapiro (1998)
J. Immunol. 161, 2290-2300
 |  Abstract »  |  Full Text »  |  PDF »

A mutated human homologue to yeast Upf1 protein has a dominant-negative effect on the decay of nonsensecontaining mRNAs in mammalian cells.

X. Sun, H. A. Perlick, H. C. Dietz, and L. E. Maquat (1998)
PNAS 95, 10009-10014
 |  Abstract »  |  Full Text »  |  PDF »

Enhancer control of V(D)J recombination at the TCRbeta locus: differential effects on DNA cleavage and joining.

W. M. Hempel, P. Stanhope-Baker, N. Mathieu, F. Huang, M. S. Schlissel, and P. Ferrier (1998)
Genes & Dev. 12, 2305-2317
 |  Abstract »  |  Full Text »

Characterization and Differentiation of an Early Murine Yolk Sac-Derived IL-7-Independent Pre-Pro-B Cell Line.

L.-S. Lu and R. Auerbach (1998)
J. Immunol. 161, 1284-1291
 |  Abstract »  |  Full Text »  |  PDF »

Enhanced B-1 Cell Development, But Impaired IgG Antibody Responses in Mice Deficient in Secreted IgM.

M. Boes, C. Esau, M. B. Fischer, T. Schmidt, M. Carroll, and J. Chen (1998)
J. Immunol. 160, 4776-4787
 |  Abstract »  |  Full Text »  |  PDF »

Sequence of the Spacer in the Recombination Signal Sequence Affects V(D)J Rearrangement Frequency and Correlates with Nonrandom Vkappa Usage In Vivo.

B. Nadel, A. Tang, G. Escuro, G. Lugo, and A. J. Feeney (1998)
J. Exp. Med. 187, 1495-1503
 |  Abstract »  |  Full Text »  |  PDF »

Dependence of Antibody Somatic Diversification on Gut-Associated Lymphoid Tissue in Rabbits.

M. Vajdy, P. Sethupathi, and K. L. Knight (1998)
J. Immunol. 160, 2725-2729
 |  Abstract »  |  Full Text »  |  PDF »

The antigen-binding characteristics of mAbs derived from in vivo priming of avian B cells.

N. Michael, M. A. Accavitti, E. Masteller, and C. B. Thompson (1998)
PNAS 95, 1166-1171
 |  Abstract »  |  Full Text »  |  PDF »

Biochemical and Functional Analyses of Chromatin Changes at the TCR-{beta} Gene Locus During CD4-CD8- to CD4+CD8+ Thymocyte Differentiation.

S. Chattopadhyay, C. E. Whitehurst, F. Schwenk, and J. Chen (1998)
J. Immunol. 160, 1256-1267
 |  Abstract »  |  Full Text »  |  PDF »

Ig DH Gene Segment Transcription and Rearrangement Before Surface Expression of the Pan-B-Cell Marker CD19 in Normal Human Bone Marrow.

F.E. Bertrand III, L.G. Billips, P.D. Burrows, G.L. Gartland, H. Kubagawa, and H.W. Schroeder Jr (1997)
Blood 90, 736-744
 |  Abstract »  |  Full Text »  |  PDF »

Regulation of  T Cell Receptor delta  Gene Rearrangement by CBF/PEBP2.

P. Lauzurica, X.-P. Zhong, M. S. Krangel, and J. L. Roberts (1997)
J. Exp. Med. 185, 1193-1202
 |  Abstract »  |  Full Text »  |  PDF »

Changes in Locus-specific V(D)J Recombinase Activity Induced by Immunoglobulin Gene Products during B Cell Development.

A. Constantinescu and M. S. Schlissel (1997)
J. Exp. Med. 185, 609-620
 |  Abstract »  |  Full Text »  |  PDF »

Molecular Monitoring of Minimal Residual Disease in Follicular and Mantle Cell Non-Hodgkin's Lymphomas Treated With High-Dose Chemotherapy and Peripheral Blood Progenitor Cell Autografting.

P. Corradini, M. Astolfi, C. Cherasco, M. Ladetto, C. Voena, D. Caracciolo, A. Pileri, and C. Tarella (1997)
Blood 89, 724-491
 |  Abstract »  |  Full Text »  |  PDF »

Involvement of the Saccharomyces cerevisiae HDF1 Gene in DNA Double-strand Break Repair and Recombination.

G. J. Mages, H. M. Feldmann, and E.-L. Winnacker (1996)
J. Biol. Chem. 271, 7910-7915
 |  Abstract »  |  Full Text »  |  PDF »

Information Coding in the Mammalian Olfactory System.

L.B. Buck (1996)
Cold Spring Harb Symp Quant Biol 61, 147-155
 |  Abstract »  |  PDF »

Response.

J. A. Shapiro (1995)
Science 269, 286-288
 |  PDF »

Lymphohematopoietic progenitors immortalized by a retroviral vector harboring a dominant-negative retinoic acid receptor can recapitulate lymphoid, myeloid, and erythroid development..

S Tsai, S Bartelmez, E Sitnicka, and S Collins (1994)
Genes & Dev. 8, 2831-2841
 |  Abstract »  |  PDF »

Deletion of a DNA polymerase beta gene segment in T cells using cell type-specific gene targeting.

H Gu, J. Marth, P. Orban, H Mossmann, and K Rajewsky (1994)
Science 265, 103-106
 |  Abstract »  |  PDF »

Functional immunoglobulin transgenes guide ordered B-cell differentiation in Rag-1-deficient mice..

E Spanopoulou, C A Roman, L M Corcoran, M S Schlissel, D P Silver, D Nemazee, M C Nussenzweig, S A Shinton, R R Hardy, and D Baltimore (1994)
Genes & Dev. 8, 1030-1042
 |  Abstract »  |  PDF »

Influence of immunoglobulin heavy- and light-chain expression on B-cell differentiation..

F Young, B Ardman, Y Shinkai, R Lansford, T K Blackwell, M Mendelsohn, A Rolink, F Melchers, and F W Alt (1994)
Genes & Dev. 8, 1043-1057
 |  Abstract »  |  PDF »

Surface expression of two distinct functional antigen receptors on human gamma delta T cells.

F Davodeau, M. Peyrat, I Houde, M. Hallet, G De Libero, H Vie, and M Bonneville (1993)
Science 260, 1800-1802
 |  Abstract »  |  PDF »

Oct-2, although not required for early B-cell development, is critical for later B-cell maturation and for postnatal survival..

L M Corcoran, M Karvelas, G J Nossal, Z S Ye, T Jacks, and D Baltimore (1993)
Genes & Dev. 7, 570-582
 |  Abstract »  |  PDF »

Interleukin-7 induces N-myc and c-myc expression in normal precursor B lymphocytes..

M A Morrow, G Lee, S Gillis, G D Yancopoulos, and F W Alt (1992)
Genes & Dev. 6, 61-70
 |  Abstract »  |  PDF »

Helix-loop-helix transcription factor E47 activates germ-line immunoglobulin heavy-chain gene transcription and rearrangement in a pre-T-cell line..

M Schlissel, A Voronova, and D Baltimore (1991)
Genes & Dev. 5, 1367-1376
 |  Abstract »  |  PDF »

A thymus-specific member of the HMG protein family regulates the human T cell receptor C alpha enhancer..

M L Waterman, W H Fischer, and K A Jones (1991)
Genes & Dev. 5, 656-669
 |  Abstract »  |  PDF »

Disruption of the human SCL locus by "illegitimate" V-(D)-J recombinase activity.

P. Aplan, D. Lombardi, A. Ginsberg, J Cossman, V. Bertness, and I. Kirsch (1990)
Science 250, 1426-1429
 |  Abstract »  |  PDF »

The need for central and peripheral tolerance in the B cell repertoire.

C. Goodnow, S Adelstein, and A Basten (1990)
Science 248, 1373-1379
 |  Abstract »  |  PDF »

A T cell-specific transcriptional enhancer within the human T cell receptor delta locus.

J. Redondo, S Hata, C Brocklehurst, and M. Krangel (1990)
Science 247, 1225-1229
 |  Abstract »  |  PDF »

NBP, a protein that specifically binds an enhancer of immunoglobulin gene rearrangement: purification and characterization..

M Li, E Morzycka-Wroblewska, and S V Desiderio (1989)
Genes & Dev. 3, 1801-1813
 |  Abstract »  |  PDF »

T cell receptor gene trans-rearrangements: chimeric gamma-delta genes in normal lymphoid tissues.

B Tycko, J. Palmer, and J Sklar (1989)
Science 245, 1242-1246
 |  Abstract »  |  PDF »

The role of somatic hypermutation in the generation of antibody diversity.

D. French, R Laskov, and M. Scharff (1989)
Science 244, 1152-1157
 |  Abstract »  |  PDF »

Diversity, Development, Ligands, and Probable Functions of {gamma}{delta} T Cells.

S. Tonegawa, A. Berns, M. Bonneville, A. Farr, I. Ishida, K. Ito, S. Itohara, C.A. Janeway Jr., O. Kanagawa, M. Katsuki, et al. (1989)
Cold Spring Harb Symp Quant Biol 54, 31-44
 |  Abstract »  |  PDF »

Developmental Regulation of the TCR{alpha}{delta} Locus.

A. Winoto and D. Baltimore (1989)
Cold Spring Harb Symp Quant Biol 54, 87-92
 |  Abstract »  |  PDF »

Control of VDJ Recombinase Activity.

P. Ferrier, B. Krippl, A.J. Furley, T.K. Blackwell, H. Suh, M. Mendelsohn, A. Winoto, W.D. Cook, L. Hood, F. Costantini, et al. (1989)
Cold Spring Harb Symp Quant Biol 54, 191-202
 |  Abstract »  |  PDF »

Growth and Selection of B Cells In Vivo.

K. Rajewsky, H. Gu, P. Vieira, and I. Forster (1989)
Cold Spring Harb Symp Quant Biol 54, 209-217
 |  Abstract »  |  PDF »

A Combinatorial System for Cloning and Expressing the Catalytic Antibody Repertoire in Escherichia coli.

S.A. Iverson, L. Sastry, W.D. Huse, J.A. Sorge, S.J. Benkovic, and R.A. Lerner (1989)
Cold Spring Harb Symp Quant Biol 54, 273-281
 |  Abstract »  |  PDF »

Reconstruction of an immune system.

G. Yancopoulos and F. Alt (1988)
Science 241, 1581-1583
 |  PDF »

Evolutionary and somatic selection of the antibody repertoire in the mouse.

K Rajewsky, I Forster, and A Cumano (1987)
Science 238, 1088-1094
 |  Abstract »  |  PDF »

V(D)J recombination is not activated by demethylation of the kappa locus.

S. R. Cherry, C. Beard, R. Jaenisch, and D. Baltimore (2000)
PNAS 97, 8467-8472
 |  Abstract »  |  Full Text »  |  PDF »

To Advertise   |   Find Products