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Science 13 November 1987:
Vol. 238. no. 4829, pp. 952 - 956
DOI: 10.1126/science.2890210
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Articles

Science, Vol 238, Issue 4829, 952-956
Copyright © 1987 by American Association for the Advancement of Science

articles

Long-term neuropathological and neurochemical effects of nucleus basalis lesions in the rat

GW Arendash, WJ Millard, AJ Dunn, and EM Meyer

Department of Biology, University of South Florida, Tampa 33620.

The long-term effects of excitotoxic lesions in the nucleus basalis magnocellularis of the rat were found to mimic several neuropathological and chemical changes associated with Alzheimer's disease. Neuritic plaque-like structures, neurofibrillary changes, and neuronal atrophy or loss were observed in the frontoparietal cortex, hippocampus, amygdala, and entorhinal cortex 14 months after the lesions were made. Cholinergic markers in neocortex were reduced, while catecholamine and indoleamine metabolism was largely unaffected at this time. Bilateral lesions of the nucleus basalis magnocellularis increased somatostatin and neuropeptide Y in the cortex of the rat by at least 138 and 284 percent, respectively, suggesting a functional interaction between cholinergic and peptidergic neurons that may differ from that in Alzheimer's disease.


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Distinctive Morphological Features of a Subset of Cortical Neurons Grown in the Presence of Basal Forebrain Neurons In Vitro.
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Science. ISSN 0036-8075 (print), 1095-9203 (online)