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Science 6 November 1987:
Vol. 238. no. 4828, pp. 797 - 799
DOI: 10.1126/science.3672127

Articles

Science, Vol 238, Issue 4828, 797-799
Copyright © 1987 by American Association for the Advancement of Science


articles

A nerve growth factor-induced gene encodes a possible transcriptional regulatory factor

J Milbrandt

Department of Pathology, Washington University School of Medicine, St. Louis, MO 63110.

Nerve growth factor (NGF) is a trophic agent that promotes the outgrowth of nerve fibers from sympathetic and sensory ganglia. The neuronal differentiation stimulated by this hormone was examined in the NGF-responsive cell line PC12. Differential hybridization was used to screen a complementary DNA library constructed from PC12 cells treated with NGF and cycloheximide. One of the complementary DNA clones that was rapidly induced by NGF was found to have a nucleotide sequence that predicts a 54-kilodalton protein with homology to transcriptional regulatory proteins. This clone, NGFI-A, contains three tandemly repeated copies of the 28- to 30-amino acid "zinc finger" domain present in Xenopus laevis TFIIIA and other DNA-binding proteins. It also contains another highly conserved unit of eight amino acids that is repeated at least 11 times. The NGFI-A gene is expressed at relatively high levels in the brain, lung, and superior cervical ganglion of the adult rat.


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   Abstract »    PDF »
Emotional stress induces immediate-early gene expression in rat heart via activation of alpha - and beta -adrenoceptors.
T. Ueyama, K.-I. Yoshida, and E. Senba (1999)
Am J Physiol Heart Circ Physiol 277, H1553-H1561
   Abstract »    Full Text »    PDF »
Brain Gene Expression During REM Sleep Depends on Prior Waking Experience.
S. Ribeiro, V. Goyal, C. V. Mello, and C. Pavlides (1999)
Learn. Mem. 6, 500-508
   Abstract »    Full Text »
Daily Rhythm of Spontaneous Immediate-Early Gene Expression in the Rat Suprachiasmatic Nucleus.
M. E. Guido, L. B. de Guido, D. Goguen, H. A. Robertson, and B. Rusak (1999)
J Biol Rhythms 14, 275-280
   Abstract »    PDF »
The Ras Suppressor, RSU-1, Enhances Nerve Growth Factor-induced Differentiation of PC12 Cells and Induces p21CIP Expression.
L. Masuelli, S. Ettenberg, F. Vasaturo, K. Vestergaard-Sykes, and M. L. Cutler (1999)
Cell Growth Differ. 10, 555-564
   Abstract »    Full Text »
Insulin-induced Early Growth Response Gene (Egr-1) Mediates a Short Term Repression of Rat Malic Enzyme Gene Transcription.
I. Barroso and P. Santisteban (1999)
J. Biol. Chem. 274, 17997-18004
   Abstract »    Full Text »    PDF »
CpG oligodeoxynucleotides rescue BKS-2 immature B cell lymphoma from anti-IgM-mediated growth inhibition by up-regulation of egr-1.
S.-S. Han, S.-T. Chung, D. A. Robertson, R. L. Chelvarajan, and S. Bondada (1999)
Int. Immunol. 11, 871-879
   Abstract »    Full Text »    PDF »
Vascular Endothelial Cell Growth Factor-Induced Tissue Factor Expression in Endothelial Cells Is Mediated by EGR-1.
D. Mechtcheriakova, A. Wlachos, H. Holzmuller, B. R. Binder, and E. Hofer (1999)
Blood 93, 3811-3823
   Abstract »    Full Text »    PDF »
The Stimulatory Action and the Development of Tolerance to Caffeine Is Associated with Alterations in Gene Expression in Specific Brain Regions.
P. Svenningsson, G. G. Nomikos, and B. B. Fredholm (1999)
J. Neurosci. 19, 4011-4022
   Abstract »    Full Text »    PDF »
Activation of Luteinizing Hormone beta  Gene by Gonadotropin-releasing Hormone Requires the Synergy of Early Growth Response-1 and Steroidogenic Factor-1.
C. Dorn, Q. Ou, J. Svaren, P. A. Crawford, and Y. Sadovsky (1999)
J. Biol. Chem. 274, 13870-13876
   Abstract »    Full Text »    PDF »
Early Growth Response Protein 1 Binds to the Luteinizing Hormone-{beta} Promoter and Mediates Gonadotropin-Releasing Hormone-Stimulated Gene Expression.
M. W. Wolfe and G. B. Call (1999)
Mol. Endocrinol. 13, 752-763
   Abstract »    Full Text »
Egr-1 Is a Downstream Effector of GnRH and Synergizes by Direct Interaction with Ptx1 and SF-1 To Enhance Luteinizing Hormone beta  Gene Transcription.
J. J. Tremblay and J. Drouin (1999)
Mol. Cell. Biol. 19, 2567-2576
   Abstract »    Full Text »    PDF »
COUP-TF Upregulates NGFI-A Gene Expression through an Sp1 Binding Site.
C. Pipaon, S. Y. Tsai, and M.-J. Tsai (1999)
Mol. Cell. Biol. 19, 2734-2745
   Abstract »    Full Text »    PDF »
Ternary Complex Factors Elk-1 and Sap-1a Mediate Growth Hormone-Induced Transcription of Egr-1 (Early Growth Response Factor-1) in 3T3-F442A Preadipocytes.
R. W. E. Clarkson, C. A. Shang, L. K. Levitt, T. Howard, and M. J. Waters (1999)
Mol. Endocrinol. 13, 619-631
   Abstract »    Full Text »
Actions of Caffeine in the Brain with Special Reference to Factors That Contribute to Its Widespread Use.
B. B. Fredholm, K. Battig, J. Holmen, A. Nehlig, and E. E. Zvartau (1999)
Pharmacol. Rev. 51, 83-133
   Abstract »    Full Text »    PDF »
Pathways of Egr-1-Mediated Gene Transcription in Vascular Biology.
E. S. Silverman and T. Collins (1999)
Am. J. Pathol. 154, 665-670
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Mitogenic Up-regulation of the PRL-1 Protein-tyrosine Phosphatase Gene by Egr-1. Egr-1 ACTIVATION IS AN EARLY EVENT IN LIVER REGENERATION.
Y. Peng, K. Du, S. Ramirez, R. H. Diamond, and R. Taub (1999)
J. Biol. Chem. 274, 4513-4520
   Abstract »    Full Text »    PDF »



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