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Science 30 October 1987:
Vol. 238. no. 4827, pp. 684 - 688
DOI: 10.1126/science.3672119
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Articles

Science, Vol 238, Issue 4827, 684-688
Copyright © 1987 by American Association for the Advancement of Science

articles

The adenovirus major late transcription factor activates the rat gamma-fibrinogen promoter

LA Chodosh, RW Carthew, JG Morgan, GR Crabtree, and PA Sharp

Department of Biology, Massachusetts Institute of Technology, Cambridge 02139.

The major late transcription factor (MLTF) is a 46-kilodalton polypeptide that specifically binds to and activates transcription from the major late promoter of adenovirus. The presence of this promoter-specific transcription factor in uninfected HeLa cell extracts suggests that MLTF is also involved in the transcription of cellular genes. This report demonstrates that MLTF specifically stimulates transcription of the rat gamma-fibrinogen gene through a high-affinity binding site. Stimulation of transcription by MLTF was not dependent on the exact position of the MLTF binding site with respect either to the transcription initiation site or to adjacent promoter elements. These results suggest that one of the cellular functions of MLTF is to control gamma-fibrinogen gene expression.


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