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Science 30 October 1987:
Vol. 238. no. 4827, pp. 678 - 682
DOI: 10.1126/science.3499667
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Articles

Science, Vol 238, Issue 4827, 678-682
Copyright © 1987 by American Association for the Advancement of Science

articles

Identification of putative human T cell receptor delta complementary DNA clones

S Hata, MB Brenner, and MS Krangel

Division of Tumor Virology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02115.

A novel T cell receptor (TCR) subunit termed TCR delta, associated with TCR gamma and CD3 polypeptides, was recently found on a subpopulation of human T lymphocytes. T cell-specific complementary DNA clones present in a human TCR gamma delta T cell complementary DNA library were obtained and characterized in order to identify candidate clones encoding TCR delta. One cross-hybridizing group of clones detected transcripts that are expressed in lymphocytes bearing TCR gamma delta but not in other T lymphocytes and are encoded by genes that are rearranged in TCR gamma delta lymphocytes but deleted in other T lymphocytes. Their sequences indicate homology to the variable, joining, and constant elements of other TCR and immunoglobulin genes. These characteristics, as well as the immunochemical data presented in a companion paper, are strong evidence that the complementary DNA clones encode TCR delta.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Distinct Roles for c-Myb and Core Binding Factor/Polyoma Enhancer-Binding Protein 2 in the Assembly and Function of a Multiprotein Complex on the TCR {delta} Enhancer In Vivo.
C. Hernandez-Munain and M. S. Krangel (2002)
J. Immunol. 169, 4362-4369
   Abstract »    Full Text »    PDF »
Self-Recognition of CD1 by {gamma}/{delta} T Cells: Implications for Innate Immunity.
F. M. Spada, E. P. Grant, P. J. Peters, M. Sugita, A. Melian, D. S. Leslie, H. K. Lee, E. van Donselaar, D. A. Hanson, A. M. Krensky, et al. (2000)
J. Exp. Med. 191, 937-948
   Abstract »    Full Text »    PDF »
The SCL Gene: From Case Report to Critical Hematopoietic Regulator.
C. G. Begley and A. R. Green (1999)
Blood 93, 2760-2770
   Full Text »    PDF »
Regulatory Elements in the Promoter of a Murine TCRD V Gene Segment.
L. J. Kienker, M. R. Ghosh, and P. W. Tucker (1998)
J. Immunol. 161, 791-804
   Abstract »    Full Text »    PDF »
Cooperation among Multiple Transcription Factors Is Required for Access to Minimal T-Cell Receptor alpha -Enhancer Chromatin In Vivo.
C. Hernandez-Munain, J. L. Roberts, and M. S. Krangel (1998)
Mol. Cell. Biol. 18, 3223-3233
   Abstract »    Full Text »
A T cell-specific transcriptional enhancer within the human T cell receptor delta locus.
J. Redondo, S Hata, C Brocklehurst, and M. Krangel (1990)
Science 247, 1225-1229
   Abstract »    PDF »
T cell receptor gene trans-rearrangements: chimeric gamma-delta genes in normal lymphoid tissues.
B Tycko, J. Palmer, and J Sklar (1989)
Science 245, 1242-1246
   Abstract »    PDF »
Developmental biology of T cell receptors.
J. Strominger (1989)
Science 244, 943-950
   Abstract »    PDF »
Extensive junctional diversity of rearranged human T cell receptor delta genes.
S Hata, K Satyanarayana, P Devlin, H Band, J McLean, J. Strominger, M. Brenner, and M. Krangel (1988)
Science 240, 1541-1544
   Abstract »    PDF »
Gene identity confirmed.
J. Marx (1988)
Science 239, 351
   PDF »
Immunochemical proof that a novel rearranging gene encodes the T cell receptor delta subunit.
H Band, F Hochstenbach, J McLean, S Hata, M. Krangel, and M. Brenner (1987)
Science 238, 682-684
   Abstract »    PDF »


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