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Science 30 October 1987:
Vol. 238. no. 4827, pp. 675 - 678
DOI: 10.1126/science.2823385
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Articles

Science, Vol 238, Issue 4827, 675-678
Copyright © 1987 by American Association for the Advancement of Science

articles

Physiological role of silent receptors of atrial natriuretic factor

T Maack, M Suzuki, FA Almeida, D Nussenzveig, RM Scarborough, GA McEnroe, and JA Lewicki

Department of Physiology, Cornell University Medical College, New York, NY 10021.

A ring-deleted analog of atrial natriuretic factor--des[Gln18, Ser19, Gly20, Leu21, Gly22] ANF4-23-NH2 (C-ANF4-23)--binds with high affinity to approximately 99% of ANF receptors in the isolated perfused rat kidney. In this preparation, C-ANF4-23 is devoid of detectable renal effects and does not antagonize any of the known renal hemodynamic and natriuretic actions of biologically active ANF1-28. In contrast, both C-ANF4-23 and ANF1-28 increase sodium excretion and decrease blood pressure in intact anesthetized rats. This apparent contradiction is resolved by the finding that the ring-deleted analog markedly increases plasma levels of endogenous immunoreactive ANF in the rat. The results show that the majority of the renal receptors of ANF are biologically silent. This new class of receptors may serve as specific peripheral storage-clearance binding sites, acting as a hormonal buffer system to modulate plasma levels of ANF.


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Ligand-dependent regulation of NPR-A gene expression in inner medullary collecting duct cells.
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Natriuretic Peptide Regulation of Endochondral Ossification. EVIDENCE FOR POSSIBLE ROLES OF THE C-TYPE NATRIURETIC PEPTIDE/GUANYLYL CYCLASE-B PATHWAY.
A. Yasoda, Y. Ogawa, M. Suda, N. Tamura, K. Mori, Y. Sakuma, H. Chusho, K. Shiota, K. Tanaka, and K. Nakao (1998)
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Mechanism for the Nonlinear Pharmacokinetics of Erythropoietin in Rats.
M. Kato, H. Kamiyama, A. Okazaki, K. Kumaki, Y. Kato, and Y. Sugiyama (1997)
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   Abstract »    Full Text »    PDF »
Atrial Natriuretic Peptide Inhibits Mitogen-activated Protein Kinase through the Clearance Receptor. POTENTIAL ROLE IN THE INHIBITION OF ASTROCYTE PROLIFERATION.
B. A. Prins, M. J. Weber, R.-M. Hu, A. Pedram, M. Daniels, and E. R. Levin (1996)
J. Biol. Chem. 271, 14156-14162
   Abstract »    Full Text »    PDF »
Plasma Brain Natriuretic Peptide as an Indicator of Left Ventricular Systolic Function and Long-term Survival After Acute Myocardial Infarction : Comparison With Plasma Atrial Natriuretic Peptide and N-Terminal Proatrial Natriuretic Peptide.
T. Omland, A. Aakvaag, V. V. S. Bonarjee, K. Caidahl, R. T. Lie, D. W. T. Nilsen, J. A. Sundsfjord, and K. Dickstein (1996)
Circulation 93, 1963-1969
   Abstract »    Full Text »
Acute and Chronic Neutral Endopeptidase Inhibition in Rats With Aortocaval Shunt.
R. Willenbrock, M. Scheuermann, K. Hohnel, F. C. Luft, and R. Dietz (1996)
Hypertension 27, 1259-1266
   Abstract »    Full Text »
Molecular Determinants of the Clearance Function of Type C Receptors of Natriuretic Peptides.
D. Cohen, G. Y. Koh, L. N. Nikonova, J. G. Porter, and T. Maack (1996)
J. Biol. Chem. 271, 9863-9869
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Atrial Natriuretic Peptide Suppresses the Transcription of Its Guanylyl Cyclase-linked Receptor.
L. Cao, J. Wu, and D. G. Gardner (1995)
J. Biol. Chem. 270, 24891-24897
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Localization of Atrial Natriuretic Factor Receptors in the Mesenteric Arterial Bed : Comparison With Angiotensin II and Endothelin Receptors.
H. de Leon, M.-C. Bonhomme, G. Thibault, and R. Garcia (1995)
Circ. Res. 77, 64-72
   Abstract »    Full Text »
Endopeptidase Inhibition in Angiotensin-Induced Hypertension : Effect of SCH 39370 in Sheep.
C. J. Charles, E. A. Espiner, A. M. Richards, and E. J. Sybertz (1995)
Hypertension 26, 89-94
   Abstract »    Full Text »
Interaction of Atrial Natriuretic Peptide with Its Receptors in Bovine Lung Membranes.
T. Abe, Y. Arakawa, A. K. Rajasekaran, T.-H. Yu, and O. Wada (1995)
J. Biol. Chem. 270, 7672-7678
   Abstract »    Full Text »    PDF »
Guanylyl Cyclases: Ligands and Functions.
T.D. Chrisman, S. Schulz, and D.L. Garbers (1992)
Cold Spring Harb Symp Quant Biol 57, 155-161
   Abstract »    PDF »
Selective activation of the B natriuretic peptide receptor by C-type natriuretic peptide (CNP).
K. Koller, D. Lowe, G. Bennett, N Minamino, K Kangawa, H Matsuo, and D. Goeddel (1991)
Science 252, 120-123
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Effects of Nitrovasodilators, Endothelium-dependent Vasodilators, and Atrial Peptides on cGMP.
F. Murad, D. Leitman, S. Waldman, C.-H. Chang, M. Hirata, and K. Kohse (1988)
Cold Spring Harb Symp Quant Biol 53, 1005-1009
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Molecular and Cellular Physiology of the Dissociation of Atrial Natriuretic Peptide from Guanylyl Cyclase A Receptors.
M. A. R. Vieira, M. Gao, L. N. Nikonova, and T. Maack (2001)
J. Biol. Chem. 276, 36438-36445
   Abstract »    Full Text »    PDF »
Dwarfism and early death in mice lacking C-type natriuretic peptide.
H. Chusho, N. Tamura, Y. Ogawa, A. Yasoda, M. Suda, T. Miyazawa, K. Nakamura, K. Nakao, T. Kurihara, Y. Komatsu, et al. (2001)
PNAS 98, 4016-4021
   Abstract »    Full Text »    PDF »
Dietary salt supplementation selectively downregulates NPR-C receptor expression in kidney independently of ANP.
J.-Z. Sun, S.-J. Chen, E. Majid-Hasan, S. Oparil, and Y.-F. Chen (2002)
Am J Physiol Renal Physiol 282, F220-F227
   Abstract »    Full Text »    PDF »


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