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Science 30 October 1987:
Vol. 238. no. 4827, pp. 666 - 669
DOI: 10.1126/science.2890207
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Articles

Science, Vol 238, Issue 4827, 666-669
Copyright © 1987 by American Association for the Advancement of Science

articles

The amyloid beta protein gene is not duplicated in brains from patients with Alzheimer's disease

RE Tanzi, ED Bird, SA Latt, and RL Neve

Division of Genetics and Mental Retardation Center, Children's Hospital, Boston, MA.

Complementary DNAs (cDNAs) encoding portions of the amyloid beta protein were used to investigate possible amyloid gene duplication in sporadic Alzheimer's disease. A strategy employing two Eco RI restriction fragment length polymorphisms (RFLPs) detected by the amyloid cDNAs was used. RFLPs allow the detection of a 2:1 gene dosage in the DNA of any individual who is heterozygous for a particular RFLP. The amyloid gene regions homologous to the cDNAs used were not duplicated in the DNA from brains of individuals with sporadic Alzheimer's disease. Similar results were also obtained with a strategy employing a test for 3:2 gene dosage.


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