Science 30 October 1987: Vol. 238. no. 4827, pp. 650 - 656 DOI: 10.1126/science.2823383

Prev | Table of Contents | Next

Articles

Analysis of {alpha}2-adrenergic Receptors and Effect of Brimonidine on Matrix Metalloproteinases and Their Inhibitors in Human Ciliary Body.

Y. H. Ooi, D.-J. Oh, and D. J. Rhee (2009)
Invest. Ophthalmol. Vis. Sci. 50, 4237-4243
 |  Abstract »  |  Full Text »  |  PDF »

International Union of Basic and Clinical Pharmacology. LXXIII. Nomenclature for the Formyl Peptide Receptor (FPR) Family.

R. D. Ye, F. Boulay, J. M. Wang, C. Dahlgren, C. Gerard, M. Parmentier, C. N. Serhan, and P. M. Murphy (2009)
Pharmacol. Rev. 61, 119-161
 |  Abstract »  |  Full Text »  |  PDF »

Rich Tapestry of G Protein-Coupled Receptor Signaling and Regulatory Mechanisms.

V. V. Gurevich and E. V. Gurevich (2008)
Mol. Pharmacol. 74, 312-316
 |  Abstract »  |  Full Text »  |  PDF »

Compensatory Changes in the Noradrenergic Nervous System in the Locus Ceruleus and Hippocampus of Postmortem Subjects with Alzheimer's Disease and Dementia with Lewy Bodies.

P. Szot, S. S. White, J. L. Greenup, J. B. Leverenz, E. R. Peskind, and M. A. Raskind (2006)
J. Neurosci. 26, 467-478
 |  Abstract »  |  Full Text »  |  PDF »

Structure/Function Analysis of {alpha}2A-Adrenergic Receptor Interaction with G Protein-coupledReceptor Kinase 2.

C. S. Pao and J. L. Benovic (2005)
J. Biol. Chem. 280, 11052-11058
 |  Abstract »  |  Full Text »  |  PDF »

Association of distinct {alpha}2 adrenoceptor and serotonin transporter polymorphisms with constipation and somatic symptoms in functional gastrointestinal disorders.

H J Kim, M Camilleri, P J Carlson, F Cremonini, I Ferber, D Stephens, S McKinzie, A R Zinsmeister, and R Urrutia (2004)
Gut 53, 829-837
 |  Abstract »  |  Full Text »  |  PDF »

Identification of Duplicated Fourth {alpha}2-Adrenergic Receptor Subtype by Cloning and Mapping of Five Receptor Genes in Zebrafish.

J. O. Ruuskanen, H. Xhaard, A. Marjamaki, E. Salaneck, T. Salminen, Y.-L. Yan, J. H. Postlethwait, M. S. Johnson, D. Larhammar, and M. Scheinin (2004)
Mol. Biol. Evol. 21, 14-28
 |  Abstract »  |  Full Text »  |  PDF »

Resistance of Macrophages to Mycobacterium avium Is Induced by {alpha}2-Adrenergic Stimulation.

K. E. Weatherby, B. S. Zwilling, and W. P. Lafuse (2003)
Infect. Immun. 71, 22-29
 |  Abstract »  |  Full Text »  |  PDF »

The Third Intracellular Loop of alpha 2-Adrenergic Receptors Determines Subtype Specificity of Arrestin Interaction.

J. L. DeGraff, V. V. Gurevich, and J. L. Benovic (2002)
J. Biol. Chem. 277, 43247-43252
 |  Abstract »  |  Full Text »  |  PDF »

Effects of an alpha 2-adrenergic agonist on gastrointestinal transit, colonic motility, and sensation in humans.

B. E. Viramontes, A. Malcolm, M. Camilleri, L. A. Szarka, S. McKinzie, D. D. Burton, and A. R. Zinsmeister (2001)
Am J Physiol Gastrointest Liver Physiol 281, G1468-G1476
 |  Abstract »  |  Full Text »  |  PDF »

Cooling Evokes Redistribution of alpha 2C-Adrenoceptors from Golgi to Plasma Membrane in Transfected Human Embryonic Kidney 293 Cells.

S. C. Jeyaraj, M. A. Chotani, S. Mitra, H. E. Gregg, N. A. Flavahan, and K. J. Morrison (2001)
Mol. Pharmacol. 60, 1195-1200
 |  Abstract »  |  Full Text »  |  PDF »

Molecular Mechanism for Agonist-Promoted alpha 2A-Adrenoceptor Activation by Norepinephrine and Epinephrine.

T. Nyrönen, M. Pihlavisto, J. M. Peltonen, A.-M. Hoffrén, M. Varis, T. Salminen, S. Wurster, A. Marjamäki, L. Kanerva, E. Katainen, et al. (2001)
Mol. Pharmacol. 59, 1343-1354
 |  Abstract »  |  Full Text »

Transcriptional Down-Regulation of the Human alpha 2C-Adrenergic Receptor by cAMP.

S. Schaak, C. Cayla, A. Lymperopoulos, C. Flordellis, D. Cussac, C. Denis, and H. Paris (2000)
Mol. Pharmacol. 58, 821-827
 |  Abstract »  |  Full Text »

Alpha2 adrenoceptors regulate proliferation of human intestinal epithelial cells.

S Schaak, D Cussac, C Cayla, J C Devedjian, R Guyot, H Paris, and C Denis (2000)
Gut 47, 242-250
 |  Abstract »  |  Full Text »  |  PDF »

alpha 2A-Adrenergic Receptor Stimulation Potentiates Calcium Release in Platelets by Modulating cAMP Levels.

I. M. L. W. Keularts, R. M. A. van Gorp, M. A. H. Feijge, W. M. J. Vuist, and J. W. M. Heemskerk (2000)
J. Biol. Chem. 275, 1763-1772
 |  Abstract »  |  Full Text »  |  PDF »

Functional correlates of {alpha}2A-adrenoceptor gene polymorphism in the HANE study.

M. C. Michel, C. Plogmann, T. Philipp, and O.-E. Brodde (1999)
Nephrol. Dial. Transplant. 14, 2657-2663
 |  Abstract »  |  Full Text »  |  PDF »

Receptor Subtype-Induced Targeting and Subtype-Specific Internalization of Human alpha 2-Adrenoceptors in PC12 Cells.

T. Olli-Lahdesmaki, J. Kallio, and M. Scheinin (1999)
J. Neurosci. 19, 9281-9288
 |  Abstract »  |  Full Text »  |  PDF »

Characterization of {alpha}2 Adrenergic Receptor Subtypes in Human Ocular Tissue Homogenates.

D. B. Bylund and D. M. Chacko (1999)
Invest. Ophthalmol. Vis. Sci. 40, 2299-2306
 |  Abstract »  |  Full Text »  |  PDF »

Three-dimensional Models of alpha 2A-Adrenergic Receptor Complexes Provide a Structural Explanation for Ligand Binding.

T. Salminen, M. Varis, T. Nyronen, M. Pihlavisto, A.-M. Hoffren, T. Lonnberg, A. Marjamaki, H. Frang, J.-M. Savola, M. Scheinin, et al. (1999)
J. Biol. Chem. 274, 23405-23413
 |  Abstract »  |  Full Text »  |  PDF »

Role of Arrestins in Endocytosis and Signaling of alpha 2-Adrenergic Receptor Subtypes.

J. L. DeGraff, A. W. Gagnon, J. L. Benovic, and M. J. Orsini (1999)
J. Biol. Chem. 274, 11253-11259
 |  Abstract »  |  Full Text »  |  PDF »

Differential Coupling of alpha 1-, alpha 2-, and beta -Adrenergic Receptors to Mitogen-activated Protein Kinase Pathways and Differentiation in Transfected PC12 Cells.

N. G. Williams, H. Zhong, and K. P. Minneman (1998)
J. Biol. Chem. 273, 24624-24632
 |  Abstract »  |  Full Text »  |  PDF »

alpha 2C-Adrenoceptor-Overexpressing Mice Are Impaired in Executing Nonspatial and Spatial Escape Strategies.

M. Björklund, J. Sirviö, J. Puoliväli, J. Sallinen, P. Jäkälä, M. Scheinin, B. K. Kobilka, and P. Riekkinen Jr. (1998)
Mol. Pharmacol. 54, 569-576
 |  Abstract »  |  Full Text »

A Point Mutation (D79N) of the alpha 2A Adrenergic Receptor Abolishes the Antiepileptogenic Action of Endogenous Norepinephrine.

S. Janumpalli, L. S. Butler, L. B. MacMillan, L. E. Limbird, and J. O. McNamara (1998)
J. Neurosci. 18, 2004-2008
 |  Abstract »  |  Full Text »  |  PDF »

Chloroethylclonidine Binds Irreversibly to Exposed Cysteines in the Fifth Membrane-Spanning Domain of the Human alpha 2A-Adrenergic Receptor.

A. Marjamäki, M. Pihlavisto, V. Cockcroft, P. Heinonen, J.-M. Savola, and M. Scheinin (1998)
Mol. Pharmacol. 53, 370-376
 |  Abstract »  |  Full Text »

alpha 2-Adrenergic receptors increase cell migration and decrease F-actin labeling in rat aortic smooth muscle cells.

J. G. Richman and J. W. Regan (1998)
Am J Physiol Cell Physiol 274, C654-C662
 |  Abstract »  |  Full Text »  |  PDF »

Distribution of mRNA Encoding Three alpha 2-Adrenergic Receptor Subtypes in the Developing Mouse Embryo Suggests a Role for the alpha 2A Subtype in Apoptosis.

R.-X. Wang and L. E. Limbird (1997)
Mol. Pharmacol. 52, 1071-1080
 |  Abstract »  |  Full Text »

Ras-dependent Mitogen-activated Protein Kinase Activation by G Protein-coupled Receptors. CONVERGENCE OF Gi- AND Gq-MEDIATED PATHWAYS ON CALCIUM/CALMODULIN, Pyk2, AND Src KINASE.

G. J. Della Rocca, T. van Biesen, Y. Daaka, D. K. Luttrell, L. M. Luttrell, and R. J. Lefkowitz (1997)
J. Biol. Chem. 272, 19125-19132
 |  Abstract »  |  Full Text »  |  PDF »

.

D. B. Bylund, L. J. Iversen, W. J. Matulka, and D. M. Chacko (1997)
J. Pharmacol. Exp. Ther. 281, 1171-1177
 |  Abstract »  |  Full Text »

Genomic Organization of the Rat Pituitary Adenylate Cyclase-activating Polypeptide Receptor Gene. ALTERNATIVE SPLICING WITHIN THE 5prime -UNTRANSLATED REGION.

T. K. Chatterjee, X. Liu, R. L. Davisson, and R. A. Fisher (1997)
J. Biol. Chem. 272, 12122-12131
 |  Abstract »  |  Full Text »  |  PDF »

HepG2 and SK-N-MC: Two Human Models to Study Alpha-2 Adrenergic Receptors of the Alpha-2C Subtype.

S. Schaak, C. Cayla, R. Blaise, F. Quinchon, and H. Paris (1997)
J. Pharmacol. Exp. Ther. 281, 983-991
 |  Abstract »  |  Full Text »

The Second Intracellular Loop of the alpha 2-Adrenergic Receptors Determines Subtype-specific Coupling to cAMP Production.

J. Nasman, C. C. Jansson, and K. E.O. Akerman (1997)
J. Biol. Chem. 272, 9703-9708
 |  Abstract »  |  Full Text »  |  PDF »

Characterization of the Genomic Structure, Promoter Region, and a Tetranucleotide Repeat Polymorphism of the Human Neurotensin Receptor Gene.

F. Le, K. Groshan, X. P. Zeng, and E. Richelson (1997)
J. Biol. Chem. 272, 1315-1322
 |  Abstract »  |  Full Text »  |  PDF »

Catecholamine regulation of the prefrontal cortex.

A. F. T. Arnsten (1997)
J Psychopharmacol 11, 151-162
 |  Abstract »  |  PDF »

Chimeric Mutagenesis of Putative G-protein Coupling Domains of the alpha 2A-Adrenergic Receptor. LOCALIZATION OF TWO REDUNDANT AND FULLY COMPETENT G.

M. G. Eason and S. B. Liggett (1996)
J. Biol. Chem. 271, 12826-12832
 |  Abstract »  |  Full Text »  |  PDF »

Phosphatidylinositol 3-Kinase Is an Early Intermediate in the Gbeta[IMAGE]-mediated Mitogen-activated Protein Kinase Signaling Pathway.

B. E. Hawes, L. M. Luttrell, T. van Biesen, and R. J. Lefkowitz (1996)
J. Biol. Chem. 271, 12133-12136
 |  Abstract »  |  Full Text »  |  PDF »

The Contribution of {alpha}2-Noradrenergic Mechanisms to Prefrontal Cortical Cognitive Function: Potential Significance for Attention-Deficit Hyperactivity Disorder.

A. F.T. Arnsten, J. C. Steere, and R. D. Hunt (1996)
Arch Gen Psychiatry 53, 448-455
 |  Abstract »  |  PDF »

The Three alpha(2)-Adrenergic Receptor Subtypes Achieve Basolateral Localization in Madin-Darby Canine Kidney II Cells via Different Targeting Mechanisms.

M. Wozniak and L. E. Limbird (1996)
J. Biol. Chem. 271, 5017-5024
 |  Abstract »  |  Full Text »  |  PDF »

Receptor and Membrane Interaction Sites on Gbeta.

J. M. Taylor, G. G. Jacob-Mosier, R. G. Lawton, M. VanDort, and R. R. Neubig (1996)
J. Biol. Chem. 271, 3336-3339
 |  Abstract »  |  Full Text »  |  PDF »

Arrangement of Transmembrane Domains in Adrenergic Receptors.

T. Mizobe, M. Maze, V. Lam, S. Suryanarayana, and B. K. Kobilka (1996)
J. Biol. Chem. 271, 2387-2389
 |  Abstract »  |  Full Text »  |  PDF »

Truncation of the C-terminal Tail of the Follitropin Receptor Does Not Impair the Agonist- or Phorbol Ester-induced Receptor Phosphorylation and Uncoupling.

R. W. Hipkin, X. Liu, and M. Ascoli (1995)
J. Biol. Chem. 270, 26683-26689
 |  Abstract »  |  Full Text »  |  PDF »

Identification of a G(s) Coupling Domain in the Amino Terminus of the Third Intracellular Loop of the alpha[IMAGE]-Adrenergic Receptor.

M. G. Eason and S. B. Liggett (1995)
J. Biol. Chem. 270, 24753-24760
 |  Abstract »  |  Full Text »  |  PDF »

Effect of Cellular Expression of Pleckstrin Homology Domains on G[IMAGE]-coupled Receptor Signaling.

L. M. Luttrell, B. E. Hawes, K. Touhara, T. v. Biesen, W. J. Koch, and R. J. Lefkowitz (1995)
J. Biol. Chem. 270, 12984-12989
 |  Abstract »  |  Full Text »  |  PDF »

Characteristics of the [IMAGE][IMAGE]/[IMAGE][IMAGE]-Adrenergic Receptor-coupled Adenylyl Cyclase System in Rat Myometrium during Pregnancy.

S. Mhaouty, J. Cohen-Tannoudji, R. Bouet-Alard, I. Limon-Boulez, J.-P. Maltier, and C. Legrand (1995)
J. Biol. Chem. 270, 11012-11016
 |  Abstract »  |  Full Text »  |  PDF »

Effect of Circulating Epinephrine on Platelet Function and Hematocrit.

S. E. Kjeldsen, A. B. Weder, B. Egan, R. Neubig, A. J. Zweifler, and S. Julius (1995)
Hypertension 25, 1096-1105
 |  Abstract »  |  Full Text »

Four Consecutive Serines in the Third Intracellular Loop Are the Sites for beta-Adrenergic Receptor Kinase-mediated Phosphorylation and Desensitization of the alpha[IMAGE]-Adrenergic Receptor.

M. G. Eason, S. P. Moreira, and S. B. Liggett (1995)
J. Biol. Chem. 270, 4681-4688
 |  Abstract »  |  Full Text »  |  PDF »

Platelet {alpha}2-adrenoreceptors in depression: a critical examination.

F. Grossman, H. K. Manji, and W. Z. Potter (1993)
J Psychopharmacol 7, 4-18
 |  Abstract »  |  PDF »

Molecular characterization of the human beta 3-adrenergic receptor.

L. Emorine, S Marullo, M. Briend-Sutren, G Patey, K Tate, C Delavier-Klutchko, and A. Strosberg (1989)
Science 245, 1118-1121
 |  Abstract »  |  PDF »

Molecular genetics of human blue cone monochromacy.

J Nathans, C. Davenport, I. Maumenee, R. Lewis, J. Hejtmancik, M Litt, E Lovrien, R Weleber, B Bachynski, F Zwas, et al. (1989)
Science 245, 831-838
 |  Abstract »  |  PDF »

Hydrophobic organization of membrane proteins.

D. Rees, L DeAntonio, and D Eisenberg (1989)
Science 245, 510-513
 |  Abstract »  |  PDF »

Cloning and sequencing of porcine LH-hCG receptor cDNA: variants lacking transmembrane domain.

H Loosfelt, M Misrahi, M Atger, R Salesse, M. Vu Hai-Luu Thi, A Jolivet, A Guiochon-Mantel, S Sar, B Jallal, J Garnier, et al. (1989)
Science 245, 525-528
 |  Abstract »  |  PDF »

Selective amplification and cloning of four new members of the G protein-coupled receptor family.

F Libert, M Parmentier, A Lefort, C Dinsart, J Van Sande, C Maenhaut, M. Simons, J. Dumont, and G Vassart (1989)
Science 244, 569-572
 |  Abstract »  |  PDF »

A chemoattractant receptor controls development in Dictyostelium discoideum.

P. Klein, T. Sun, C. Saxe 3rd, A. Kimmel, R. Johnson, and P. Devreotes (1988)
Science 241, 1467-1472
 |  Abstract »  |  PDF »

Heterologous expression of excitability proteins: route to more specific drugs?.

H. Lester (1988)
Science 241, 1057-1063
 |  Abstract »  |  PDF »

From epinephrine to cyclic AMP.

A Levitzki (1988)
Science 241, 800-806
 |  Abstract »  |  PDF »

Molecular characterization of a functional cDNA encoding the serotonin 1c receptor.

D Julius, A. MacDermott, R Axel, and T. Jessell (1988)
Science 241, 558-564
 |  Abstract »  |  PDF »

Fertilization events induced by neurotransmitters after injection of mRNA in Xenopus eggs.

D Kline, L Simoncini, G Mandel, R. Maue, R. Kado, and L. Jaffe (1988)
Science 241, 464-467
 |  Abstract »  |  PDF »

Chimeric alpha 2-,beta 2-adrenergic receptors: delineation of domains involved in effector coupling and ligand binding specificity.

B. Kobilka, T. Kobilka, K Daniel, J. Regan, M. Caron, and R. Lefkowitz (1988)
Science 240, 1310-1316
 |  Abstract »  |  PDF »

Structure-Function Analysis of the {beta}-Adrenergic Receptor.

R.A.F. Dixon, I.S. Sigal, and C.D. Strader (1988)
Cold Spring Harb Symp Quant Biol 53, 487-497
 |  Abstract »  |  PDF »

Functional Domains of a Peptide Hormone Receptor: The {alpha}-Factor Receptor (STE2 Gene Product) of the Yeast Saccharomyces cerevisiae.

K.J. Blumer, J.E. Reneke, W.E. Courchesne, and J. Thorner (1988)
Cold Spring Harb Symp Quant Biol 53, 591-603
 |  Abstract »  |  PDF »

cAMP Receptor and G-protein Interactions Control Development in Dictyostelium.

M. Pupillo, P. Klein, R. Vaughan, G. Pitt, P. Lilly, T. Sun, P. Devreotes, A. Kumagai, and R. Firtel (1988)
Cold Spring Harb Symp Quant Biol 53, 657-665
 |  Abstract »  |  PDF »

A Four Amino Acid Deletion Polymorphism in the Third Intracellular Loop of the Human alpha 2C-Adrenergic Receptor Confers Impaired Coupling to Multiple Effectors.

K. M. Small, S. L. Forbes, F. F. Rahman, K. M. Bridges, and S. B. Liggett (2000)
J. Biol. Chem. 275, 23059-23064
 |  Abstract »  |  Full Text »  |  PDF »

Phenoxybenzamine Binding Reveals the Helical Orientation of the Third Transmembrane Domain of Adrenergic Receptors.

H. Frang, V. Cockcroft, T. Karskela, M. Scheinin, and A. Marjamaki (2001)
J. Biol. Chem. 276, 31279-31284
 |  Abstract »  |  Full Text »  |  PDF »

To Advertise   |   Find Products