Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Site Tools

  • AAAS
  • Subscribe
  • Feedback

Site Search

Search Advanced

Science 23 October 1987:
Vol. 238. no. 4826, pp. 524 - 526
DOI: 10.1126/science.2443979
Prev | Table of Contents | Next

Articles

Science, Vol 238, Issue 4826, 524-526
Copyright © 1987 by American Association for the Advancement of Science

articles

Corticotropin-releasing factor-producing neurons in the rat activated by interleukin-1

F Berkenbosch, J van Oers, A del Rey, F Tilders, and H Besedovsky

Department of Pharmacology, Medical Faculty, Free University, Amsterdam, the Netherlands.

Intraperitoneal administration of human recombinant interleukin-1 (IL-1) to rats can increase blood levels of corticosterone and adrenocorticotropic hormone (ACTH). The route by which IL-1 affects pituitary-adrenal activity is unknown. That the IL-1-induced pituitary-adrenal activation involves an increased secretion of corticotropin-releasing factor (CRF) is indicated by three lines of evidence. First, immunoneutralization of CRF markedly attenuated the IL-1-induced increase of ACTH blood levels. Second, after blockade of fast axonal transport in hypothalamic neurons by colchicine, IL-1 administration decreased the CRF immunostaining in the median eminence, indicating an enhanced release of CRF in response to IL-1. Third, IL-1 did not stimulate ACTH release from primary cultures of anterior pituitary cells. These data further support the notion of the existence of an immunoregulatory feedback circuit between the immune system and the brain.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Novel action of pituitary urocortin 2 in the regulation of expression and secretion of gonadotropins.
T. Nemoto, N. Yamauchi, and T. Shibasaki (2009)
J. Endocrinol. 201, 105-114
   Abstract »    Full Text »    PDF »
Effects of Monochromatic Light on Immune Response of Broilers.
D. Xie, Z. X. Wang, Y. L. Dong, J. Cao, J. F. Wang, J. L. Chen, and Y. X. Chen (2008)
Poult. Sci. 87, 1535-1539
   Abstract »    Full Text »    PDF »
Immune Cells and Cytokine Circuits: Toward a Working Model for Understanding Direct Immune-to-Adrenal Communication Pathways.
T. Deak (2008)
Endocrinology 149, 1433-1435
   Full Text »    PDF »
Systemic Immune Challenge Activates an Intrinsically Regulated Local Inflammatory Circuit in the Adrenal Gland.
L. Engstrom, K. Rosen, A. Angel, A. Fyrberg, L. Mackerlova, J. P. Konsman, D. Engblom, and A. Blomqvist (2008)
Endocrinology 149, 1436-1450
   Abstract »    Full Text »    PDF »
Endothelial-Specific Knockdown of Interleukin-1 (IL-1) Type 1 Receptor Differentially Alters CNS Responses to IL-1 Depending on Its Route of Administration.
S. Ching, H. Zhang, N. Belevych, L. He, W. Lai, X.-a. Pu, L. B. Jaeger, Q. Chen, and N. Quan (2007)
J. Neurosci. 27, 10476-10486
   Abstract »    Full Text »    PDF »
Corticotropin-releasing hormone receptor antagonists.
E Zoumakis, D K Grammatopoulos, and G P Chrousos (2006)
Eur. J. Endocrinol. 155, S85-S91
   Abstract »    Full Text »    PDF »
Cortisol Response to Critical Illness: Effect of Intensive Insulin Therapy.
I. Vanhorebeek, R. P. Peeters, S. Vander Perre, I. Jans, P. J. Wouters, K. Skogstrand, T. K. Hansen, R. Bouillon, and G. Van den Berghe (2006)
J. Clin. Endocrinol. Metab. 91, 3803-3813
   Abstract »    Full Text »    PDF »
Decreased Fat Mass in Interleukin-1 Receptor Antagonist-Deficient Mice: Impact on Adipogenesis, Food Intake, and Energy Expenditure.
E. Somm, E. Henrichot, A. Pernin, C. E. Juge-Aubry, P. Muzzin, J.-M. Dayer, M. J.H. Nicklin, and C. A. Meier (2005)
Diabetes 54, 3503-3509
   Abstract »    Full Text »    PDF »
Effects of {beta}-glucan obtained from the Chinese herb Astragalus membranaceus and lipopolysaccharide challenge on performance, immunological, adrenal, and somatotropic responses of weanling pigs.
X. F. Mao, X. S. Piao, C. H. Lai, D. F. Li, J. J. Xing, and B. L. Shi (2005)
J Anim Sci 83, 2775-2782
   Abstract »    Full Text »    PDF »
Endogenous Opioids and Attenuated Hypothalamic-Pituitary-Adrenal Axis Responses to Immune Challenge in Pregnant Rats.
P. J. Brunton, S. L. Meddle, S. Ma, T. Ochedalski, A. J. Douglas, and J. A. Russell (2005)
J. Neurosci. 25, 5117-5126
   Abstract »    Full Text »    PDF »
Toll-Like Receptor 4 on Nonhematopoietic Cells Sustains CNS Inflammation during Endotoxemia, Independent of Systemic Cytokines.
S. Chakravarty and M. Herkenham (2005)
J. Neurosci. 25, 1788-1796
   Abstract »    Full Text »    PDF »
Bacterial lipopolysaccharide (LPS) modulates corticotropin-releasing hormone (CRH) content and release in the brain of juvenile and adult tilapia (Oreochromis mossambicus; Teleostei).
P. P. L. M. Pepels, S. E. W. Bonga, and P. H. M. Balm (2004)
J. Exp. Biol. 207, 4479-4488
   Abstract »    Full Text »    PDF »
Cell Type-Specific Interleukin-1{beta} Signaling in the CNS.
D. Srinivasan, J.-H. Yen, D. J. Joseph, and W. Friedman (2004)
J. Neurosci. 24, 6482-6488
   Abstract »    Full Text »    PDF »
Self-rated Health Is Related to Levels of Circulating Cytokines.
M. Lekander, S. Elofsson, I.-M. Neve, L.-O. Hansson, and A.-L. Unden (2004)
Psychosom Med 66, 559-563
   Abstract »    Full Text »    PDF »
Acute stress modulates the histamine content of mast cells in the gastrointestinal tract through interleukin-1 and corticotropin-releasing factor release in rats.
H. Eutamene, V. Theodorou, J. Fioramonti, and L. Bueno (2003)
J. Physiol. 553, 959-966
   Abstract »    Full Text »    PDF »
The Role of Endogenous Interleukin-1 in Stress-Induced Adrenal Activation and Adrenalectomy-Induced Adrenocorticotropic Hormone Hypersecretion.
I. Goshen, R. Yirmiya, K. Iverfeldt, and J. Weidenfeld (2003)
Endocrinology 144, 4453-4458
   Abstract »    Full Text »    PDF »
IL-1 Plays an Important Role in Lipid Metabolism by Regulating Insulin Levels under Physiological Conditions.
T. Matsuki, R. Horai, K. Sudo, and Y. Iwakura (2003)
J. Exp. Med. 198, 877-888
   Abstract »    Full Text »    PDF »
Interleukin-6 Is an Afferent Signal to the Hypothalamo-Pituitary-Adrenal Axis during Local Inflammation in Mice.
A. V. Turnbull, S. Prehar, A. R. Kennedy, R. A. Little, and S. J. Hopkins (2003)
Endocrinology 144, 1894-1906
   Abstract »    Full Text »    PDF »
Review: Endotoxin and the hypothalamo-pituitary-adrenal (HPA) axis.
A. Beishuizen and L. G. Thijs (2003)
Innate Immunity 9, 3-24
   Abstract »    PDF »
Recovery time affects immunoendocrine responses to a second bout of endurance exercise.
O. Ronsen, J. Kjeldsen-Kragh, E. Haug, R. Bahr, and B. K. Pedersen (2002)
Am J Physiol Cell Physiol 283, C1612-C1620
   Abstract »    Full Text »    PDF »
Corticotropin-Releasing Hormone Augments Proinflammatory Cytokine Production from Macrophages In Vitro and in Lipopolysaccharide-Induced Endotoxin Shock in Mice.
S. Agelaki, C. Tsatsanis, A. Gravanis, and A. N. Margioris (2002)
Infect. Immun. 70, 6068-6074
   Abstract »    Full Text »    PDF »
Anti-{micro}-opioid-receptor IgG antibodies are commonly present in serum from healthy blood donors: evidence for a role in apoptotic immune cell death.
G. Mace, M. Jaume, C. Blanpied, L. Stephan, J. D. Coudert, P. Druet, and G. Dietrich (2002)
Blood 100, 3261-3268
   Abstract »    Full Text »    PDF »
Role of corticotropin-releasing hormone in stressor-induced alterations of sleep in rat.
F.-C. Chang and M. R. Opp (2002)
Am J Physiol Regulatory Integrative Comp Physiol 283, R400-R407
   Abstract »    Full Text »    PDF »
Subdiaphragmatic vagotomy fails to inhibit intravenous leptin-induced IL-1beta expression in the hypothalamus.
T. Hosoi, Y. Okuma, A. Ono, and Y. Nomura (2002)
Am J Physiol Regulatory Integrative Comp Physiol 282, R627-R631
   Abstract »    Full Text »    PDF »
Disease Progression in Chronic Relapsing Experimental Allergic Encephalomyelitis Is Associated with Reduced Inflammation-Driven Production of Corticosterone.
A. Stefferl, M. K. Storch, C. Linington, C. Stadelmann, H. Lassmann, T. Pohl, F. Holsboer, F. J. H. Tilders, and J. M. H. M. Reul (2001)
Endocrinology 142, 3616-3624
   Abstract »    Full Text »    PDF »
Maternal Endotoxemia Results in Obesity and Insulin Resistance in Adult Male Offspring.
C. Nilsson, B.-M. Larsson, E. Jennische, E. Eriksson, P. Bjorntorp, D. A. York, and A. Holmang (2001)
Endocrinology 142, 2622-2630
   Abstract »    Full Text »    PDF »
Role of nitric oxide in the cerebrovascular and thermoregulatory response to interleukin-1{beta}.
M. Monroy, J. W. Kuluz, D. He, W. D. Dietrich, and C. L. Schleien (2001)
Am J Physiol Heart Circ Physiol 280, H1448-H1453
   Abstract »    Full Text »    PDF »
The Sympathetic Nerve---An Integrative Interface between Two Supersystems: The Brain and the Immune System.
I. J. Elenkov, R. L. Wilder, G. P. Chrousos, and E. S. Vizi (2000)
Pharmacol. Rev. 52, 595-638
   Abstract »    Full Text »    PDF »
Neonatal Dexamethasone Treatment Increases Susceptibility to Experimental Autoimmune Disease in Adult Rats.
J. M. Bakker, A. Kavelaars, P. J. G. H. Kamphuis, P. M. Cobelens, H. H. van Vugt, F. van Bel, and C. J. Heijnen (2000)
J. Immunol. 165, 5932-5937
   Abstract »    Full Text »    PDF »
IL-1 is a mediator of increases in slow-wave sleep induced by CRH receptor blockade.
F.-C. Chang and M. R. Opp (2000)
Am J Physiol Regulatory Integrative Comp Physiol 279, R793-R802
   Abstract »    Full Text »    PDF »
Electrical stimulation of afferent vagus nerve induces IL-1beta expression in the brain and activates HPA axis.
T. Hosoi, Y. Okuma, and Y. Nomura (2000)
Am J Physiol Regulatory Integrative Comp Physiol 279, R141-R147
   Abstract »    Full Text »    PDF »
Corticotropin-Releasing Hormone Gene Expression in Primary Placental Cells Is Modulated by Cyclic Adenosine 3',5'-Monophosphate.
Y.-H. Cheng, R. C. Nicholson, B. King, E.-C. Chan, J. T. Fitter, and R. Smith (2000)
J. Clin. Endocrinol. Metab. 85, 1239-1244
   Abstract »    Full Text »
How Do Glucocorticoids Influence Stress Responses? Integrating Permissive, Suppressive, Stimulatory, and Preparative Actions.
R. M. Sapolsky, L. M. Romero, and A. U. Munck (2000)
Endocr. Rev. 21, 55-89
   Abstract »    Full Text »
How the Blood Talks to the Brain Parenchyma and the Paraventricular Nucleus of the Hypothalamus During Systemic Inflammatory and Infectious Stimuli.
S. Rivest, S. Lacroix, L. Vallières, S. Nadeau, J. Zhang, and N. Laflamme (2000)
Experimental Biology and Medicine 223, 22-38
   Abstract »    Full Text »
Prostanoid Receptors: Structures, Properties, and Functions.
S. Narumiya, Y. Sugimoto, and F. Ushikubi (1999)
Physiol Rev 79, 1193-1226
   Abstract »    Full Text »    PDF »
T-Lymphocyte Activation Increases Hypothalamic and Amygdaloid Expression of CRH mRNA and Emotional Reactivity to Novelty.
A. W. Kusnecov, R. Liang, and G. Shurin (1999)
J. Neurosci. 19, 4533-4543
   Abstract »    Full Text »    PDF »
A neuromodulatory role of interleukin-1beta in the hippocampus.
H. Schneider, F. Pitossi, D. Balschun, A. Wagner, A. del Rey, and H. O. Besedovsky (1998)
PNAS 95, 7778-7783
   Abstract »    Full Text »    PDF »
Reduced Activity of Hypothalamic Corticotropin-Releasing Hormone Neurons in Transgenic Mice with Impaired Glucocorticoid Receptor Function.
I. Dijkstra, F. J. H. Tilders, G. Aguilera, A. Kiss, C. Rabadan-Diehl, N. Barden, S. Karanth, F. Holsboer, and J. M. H. M. Reul (1998)
J. Neurosci. 18, 3909-3918
   Abstract »    Full Text »    PDF »
KAT45, a Noradrenergic Human Pheochromocytoma Cell Line Producing Corticotropin-Releasing Hormone.
M. Venihaki, K. Ain, E. Dermitzaki, A. Gravanis, and A. N. Margioris (1998)
Endocrinology 139, 713-722
   Abstract »    Full Text »    PDF »
The hypocretins: Hypothalamus-specific peptides with neuroexcitatory activity.
L. de Lecea, T. S. Kilduff, C. Peyron, X.-B. Gao, P. E. Foye, P. E. Danielson, C. Fukuhara, E. L. F. Battenberg, V. T. Gautvik, F. S. Bartlett II, et al. (1998)
PNAS 95, 322-327
   Abstract »    Full Text »    PDF »
Evidence for an Intramedullary Prostaglandin-Dependent Mechanism in the Activation of Stress-Related Neuroendocrine Circuitry by Intravenous Interleukin-1.
A. Ericsson, C. Arias, and P. E. Sawchenko (1997)
J. Neurosci. 17, 7166-7179
   Abstract »    Full Text »    PDF »
Interleukin 1{alpha} Increases Serum Leptin Concentrations in Humans.
J. E. Janik, B. D. Curti, R. V. Considine, H. C. Rager, G. C. Powers, W. G. Alvord, J. W. Smith II, B. L. Gause, and W. C. Kopp (1997)
J. Clin. Endocrinol. Metab. 82, 3084-3086
   Abstract »    Full Text »    PDF »
Long-Term Intracerebroventricular Infusion of Corticotropin-Releasing Hormone Alters Neuroendocrine, Neurochemical, Autonomic, Behavioral, and Cytokine Responses to a Systemic Inflammatory Challenge.
A. C. E. Linthorst, C. Flachskamm, S. J. Hopkins, M. E. Hoadley, MartaS. Labeur, F. Holsboer, and J. M. H. M. Reul (1997)
J. Neurosci. 17, 4448-4460
   Abstract »    Full Text »    PDF »
Inhibition of Tumor Necrosis Factor-alpha Action within the CNS Markedly Reduces the Plasma Adrenocorticotropin Response to Peripheral Local Inflammation in Rats.
A. V. Turnbull, F. J. Pitossi, J.-J. Lebrun, S. Lee, J. C. Meltzer, D. M. Nance, A. del Rey, H. O. Besedovsky, and C. Rivier (1997)
J. Neurosci. 17, 3262-3273
   Abstract »    Full Text »    PDF »
Endotoxin Decreases Corticotropin-Releasing Factor Receptor 1 Messenger Ribonucleic Acid Levels in the Rat Pituitary.
J.-M. Aubry, A. V. Turnbull, G. Pozzoli, C. Rivier, and W. Vale (1997)
Endocrinology 138, 1621-1626
   Abstract »    Full Text »    PDF »
The Neurologic Basis of Fever.
C. B. Saper and C. D. Breder (1994)
N. Engl. J. Med. 330, 1880-1886
   Full Text »
The Hypothalamic-Pituitary-Adrenal--Immune Axis: A Critical Assessment.
M. P. Lilly and D. S. Gann (1992)
Arch Surg 127, 1463-1474
   Abstract »    PDF »
The Stress Response and the Regulation of Inflammatory Disease.
E. M. Sternberg, G. P. Chrousos, R. L. Wilder, and P. W. Gold (1992)
Ann Intern Med 117, 854-866
   Abstract »    PDF »
Depression, the Immune System, and Health and Illness: Findings in Search of Meaning.
M. Stein, A. H. Miller, and R. L. Trestman (1991)
Arch Gen Psychiatry 48, 171-177
   Abstract »    PDF »
Pituitary Gland: Neuropeptides, Neurotransmitters and Growth Factors.
J. I. Koenig (1989)
Toxicol Pathol 17, 256-265
   Abstract »    PDF »
Interleukin-1 immunoreactive innervation of the human hypothalamus.
C. Breder, C. Dinarello, and C. Saper (1988)
Science 240, 321-324
   Abstract »    PDF »
ACTH regulation and IL-1.
A Arimura (1988)
Science 239, 1313
   PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)