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Science 23 October 1987: Vol. 238. no. 4826, pp. 491 - 497 DOI: 10.1126/science.2821619
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Articles
Science, Vol 238, Issue 4826, 491-497
Copyright © 1987 by American Association for the Advancement of Science
New perspectives in cell adhesion: RGD and integrins
E Ruoslahti
and
MD Pierschbacher
La Jolla Cancer Research Foundation, CA 92037.
Rapid progress has been made in the understanding of the molecular interactions that result in cell adhesion. Many adhesive proteins present in extracellular matrices and in the blood contain the tripeptide arginine-glycine-aspartic acid (RGD) as their cell recognition site. These proteins include fibronectin, vitronectin, osteopontin, collagens, thrombospondin, fibrinogen, and von Willebrand factor. The RGD sequences of each of the adhesive proteins are recognized by at least one member of a family of structurally related receptors, integrins, which are heterodimeric proteins with two membrane-spanning subunits. Some of these receptors bind to the RGD sequence of a single adhesion protein only, whereas others recognize groups of them. The conformation of the RGD sequence in the individual proteins may be critical to this recognition specificity. On the cytoplasmic side of the plasma membrane, the receptors connect the extracellular matrix to the cytoskeleton. More than ten proved or suspected RGD-containing adhesion-promoting proteins have already been identified, and the integrin family includes at least as many receptors recognizing these proteins. Together, the adhesion proteins and their receptors constitute a versatile recognition system providing cells with anchorage, traction for migration, and signals for polarity, position, differentiation, and possibly growth.
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- Concerted Action of Androgens and Mechanical Strain Shifts Bone Metabolism from High Turnover into an Osteoanabolic Mode.
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J. Exp. Med.
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- Tumor Targeting with Radiolabeled {alpha}v{beta}3 Integrin Binding Peptides in a Nude Mouse Model.
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Cancer Res.
62, 6146-6151
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- Evolution of Hematophagy in Ticks: Common Origins for Blood Coagulation and Platelet Aggregation Inhibitors from Soft Ticks of the Genus Ornithodoros.
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Mol. Biol. Evol.
19, 1695-1705
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- Savignygrin, a Platelet Aggregation Inhibitor from the Soft Tick Ornithodoros savignyi, Presents the RGD Integrin Recognition Motif on the Kunitz-BPTI Fold.
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J. Biol. Chem.
277, 21371-21378
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- Integrin {alpha}7{beta}1 in Muscular Dystrophy/Myopathy of Unknown Etiology.
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Am. J. Pathol.
160, 2135-2143
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- beta 1-Integrin-mediated Glioma Cell Adhesion and Free Radical-induced Apoptosis Are Regulated by Binding to a C-terminal Domain of PG-M/Versican.
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J. Biol. Chem.
277, 12294-12301
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- Editorial I: Is there a bleeding problem with platelet-active drugs?.
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Br. J. Anaesth.
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- {beta}1 and {beta}2 Integrins Mediate Adhesion during Macrophage Fusion and Multinucleated Foreign Body Giant Cell Formation.
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Am. J. Pathol.
160, 621-630
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- Display of Passenger Proteins on the Surface of Escherichia coli K-12 by the Enterohemorrhagic E. coli Intimin EaeA.
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J. Bacteriol.
183, 7273-7284
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- Arginine-Glycine-Aspartic Acid Motif Is Critical for Human Parechovirus 1 Entry.
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J. Virol.
75, 10000-10004
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- Osteopontin and Its Receptor {alpha}v{beta}3 Integrin Are Coexpressed in the Human Endometrium during the Menstrual Cycle But Regulated Differentially.
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J. Clin. Endocrinol. Metab.
86, 4991-5000
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- Induction of Apoptosis of Integrin-expressing Human Prostate Cancer Cells by Cyclic Arg-Gly-Asp Peptides.
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Clin. Cancer Res.
7, 3006-3011
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- Atheromatous plaque formation and thrombogenesis: formation, risk factors and therapeutic approaches.
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Eur. Heart J. Suppl.
3, I16-I22
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- Mechanical properties of alveolar epithelial cells in culture.
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J Appl Physiol
91, 65-73
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- Foot-and-mouth disease virus can utilize the C-terminal extension of coxsackievirus A9 VP1 for cell infection.
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J. Gen. Virol.
82, 1703-1711
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- An Arabidopsis thaliana protein interacts with a movement protein of Turnip crinkle virus in yeast cells and in vitro.
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J. Gen. Virol.
82, 1245-1251
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- RGD Tripeptide of Bluetongue Virus VP7 Protein Is Responsible for Core Attachment to Culicoides Cells.
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J. Virol.
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- Cross-talk between {alpha}4{beta}1/{alpha}5{beta}1 and c-Kit results in opposing effect on growth and survival of hematopoietic cells via the activation of focal adhesion kinase, mitogen-activated protein kinase, and Akt signaling pathways.
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Blood
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- Identification and characterization of a new intron in Borna disease virus.
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J. Gen. Virol.
82, 641-646
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- Use of a Whole Genome Approach To Identify Vaccine Molecules Affording Protection against Streptococcus pneumoniae Infection.
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Infect. Immun.
69, 1593-1598
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- Entry of Human Parechovirus 1.
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J. Virol.
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- Antithrombotic Therapy in Patients Undergoing Percutaneous Coronary Intervention.
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Chest
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- Cellular Responses to Mechanical Stress: Selected Contribution: Regulatory pathways involved in mechanical induction of c-fos gene expression in bone cells.
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J Appl Physiol
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- Aggregation Substance Increases Adherence and Internalization, but Not Translocation, of Enterococcus faecalis through Different Intestinal Epithelial Cells In Vitro.
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Infect. Immun.
68, 6044-6047
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