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Science 23 October 1987:
Vol. 238. no. 4826, pp. 491 - 497
DOI: 10.1126/science.2821619
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Articles

Science, Vol 238, Issue 4826, 491-497
Copyright © 1987 by American Association for the Advancement of Science

articles

New perspectives in cell adhesion: RGD and integrins

E Ruoslahti and MD Pierschbacher

La Jolla Cancer Research Foundation, CA 92037.

Rapid progress has been made in the understanding of the molecular interactions that result in cell adhesion. Many adhesive proteins present in extracellular matrices and in the blood contain the tripeptide arginine-glycine-aspartic acid (RGD) as their cell recognition site. These proteins include fibronectin, vitronectin, osteopontin, collagens, thrombospondin, fibrinogen, and von Willebrand factor. The RGD sequences of each of the adhesive proteins are recognized by at least one member of a family of structurally related receptors, integrins, which are heterodimeric proteins with two membrane-spanning subunits. Some of these receptors bind to the RGD sequence of a single adhesion protein only, whereas others recognize groups of them. The conformation of the RGD sequence in the individual proteins may be critical to this recognition specificity. On the cytoplasmic side of the plasma membrane, the receptors connect the extracellular matrix to the cytoskeleton. More than ten proved or suspected RGD-containing adhesion-promoting proteins have already been identified, and the integrin family includes at least as many receptors recognizing these proteins. Together, the adhesion proteins and their receptors constitute a versatile recognition system providing cells with anchorage, traction for migration, and signals for polarity, position, differentiation, and possibly growth.


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An Arabidopsis thaliana protein interacts with a movement protein of Turnip crinkle virus in yeast cells and in vitro.
B. Lin and L. A. Heaton (2001)
J. Gen. Virol. 82, 1245-1251
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RGD Tripeptide of Bluetongue Virus VP7 Protein Is Responsible for Core Attachment to Culicoides Cells.
B.-H. Tan, E. Nason, N. Staeuber, W. Jiang, K. Monastryrskaya, and P. Roy (2001)
J. Virol. 75, 3937-3947
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Cross-talk between {alpha}4{beta}1/{alpha}5{beta}1 and c-Kit results in opposing effect on growth and survival of hematopoietic cells via the activation of focal adhesion kinase, mitogen-activated protein kinase, and Akt signaling pathways.
R. Kapur, R. Cooper, L. Zhang, and D. A. Williams (2001)
Blood 97, 1975-1981
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Identification and characterization of a new intron in Borna disease virus.
B. Cubitt, C. Ly, and J. C. de la Torre (2001)
J. Gen. Virol. 82, 641-646
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Use of a Whole Genome Approach To Identify Vaccine Molecules Affording Protection against Streptococcus pneumoniae Infection.
T. M. Wizemann, J. H. Heinrichs, J. E. Adamou, A. L. Erwin, C. Kunsch, G. H. Choi, S. C. Barash, C. A. Rosen, H. R. Masure, E. Tuomanen, et al. (2001)
Infect. Immun. 69, 1593-1598
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Entry of Human Parechovirus 1.
P. Joki-Korpela, V. Marjomäki, C. Krogerus, J. Heino, and T. Hyypiä (2001)
J. Virol. 75, 1958-1967
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Antithrombotic Therapy in Patients Undergoing Percutaneous Coronary Intervention.
J. J. Popma, E. M. Ohman, J. Weitz, A. M. Lincoff, R. A. Harrington, and P. Berger (2001)
Chest 119, 321S-336S
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Cellular Responses to Mechanical Stress: Selected Contribution: Regulatory pathways involved in mechanical induction of c-fos gene expression in bone cells.
M. A. Peake, L. M. Cooling, J. L. Magnay, P. B. M. Thomas, and A. J. El Haj (2000)
J Appl Physiol 89, 2498-2507
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Aggregation Substance Increases Adherence and Internalization, but Not Translocation, of Enterococcus faecalis through Different Intestinal Epithelial Cells In Vitro.
S. Sartingen, E. Rozdzinski, A. Muscholl-Silberhorn, and R. Marre (2000)
Infect. Immun. 68, 6044-6047
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Substitutions at the Putative Receptor-Binding Site of an Encephalitic Flavivirus Alter Virulence and Host Cell Tropism and Reveal a Role for Glycosaminoglycans in Entry.
E. Lee and M. Lobigs (2000)
J. Virol. 74, 8867-8875
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Aggregation Substance Promotes Adherence, Phagocytosis, and Intracellular Survival of Enterococcus faecalis within Human Macrophages and Suppresses Respiratory Burst.