Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.
GoGreen Membership

Site Tools

  • AAAS
  • Subscribe
  • Feedback

Site Search

Search Advanced

Science 16 October 1987:
Vol. 238. no. 4825, pp. 366 - 369
DOI: 10.1126/science.3659920
Prev | Table of Contents | Next

Articles

Science, Vol 238, Issue 4825, 366-369
Copyright © 1987 by American Association for the Advancement of Science

articles

Behavioral recovery induced by applied electric fields after spinal cord hemisection in guinea pig

RB Borgens, AR Blight, and ME McGinnis

Center for Paralysis Research, School of Veterinary Medicine, Purdue University, West Lafayette, IN 47907.

Applied electric fields were used to promote axonal regeneration in spinal cords of adult guinea pigs. A propriospinal intersegmental reflex (the cutaneous trunci muscle reflex) was used to test lateral tract function after hemisection of the thoracic spinal cord. An electrical field (200 microvolts per millimeter, cathode rostral) applied across the lesion led to functional recovery of the cutaneous trunci muscle reflex in 25 percent of experimental animals, whereas the functional deficit remained in control animals, which were implanted with inactive stimulators.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
H+ pump-dependent changes in membrane voltage are an early mechanism necessary and sufficient to induce Xenopus tail regeneration.
D. S. Adams, A. Masi, and M. Levin (2007)
Development 134, 1323-1335
   Abstract »    Full Text »    PDF »
Controlling Cell Behavior Electrically: Current Views and Future Potential.
C. D. McCaig, A. M. Rajnicek, B. Song, and M. Zhao (2005)
Physiol Rev 85, 943-978
   Abstract »    Full Text »    PDF »
Nerve regeneration and wound healing are stimulated and directed by an endogenous electrical field in vivo.
B. Song, M. Zhao, J. Forrester, and C. McCaig (2004)
J. Cell Sci. 117, 4681-4690
   Abstract »    Full Text »    PDF »
Voluntary exercise increases axonal regeneration from sensory neurons.
R. Molteni, J.-Q. Zheng, Z. Ying, F. Gomez-Pinilla, and J. L. Twiss (2004)
PNAS 101, 8473-8478
   Abstract »    Full Text »    PDF »
Behavioral recovery from spinal cord injury following delayed application of polyethylene glycol.
R. B. Borgens, R. Shi, and D. Bohnert (2002)
J. Exp. Biol. 205, 1-12
   Abstract »    Full Text »    PDF »
Immediate recovery from spinal cord injury through molecular repair of nerve membranes with polyethylene glycol.
R. B. BORGENS and R. SHI (2000)
FASEB J 14, 27-35
   Abstract »    Full Text »


ADVERTISEMENT
Click Me!

ADVERTISEMENT
Click Me!

To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)