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Science 25 September 1987:
Vol. 237. no. 4822, pp. 1618 - 1620
DOI: 10.1126/science.3306925
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Articles

Science, Vol 237, Issue 4822, 1618-1620
Copyright © 1987 by American Association for the Advancement of Science

articles

Direct demonstration of macula densa-mediated renin secretion

O Skott and JP Briggs

An in vitro method has been used to examine whether secretion of renin from the juxtaglomerular apparatus is affected by changes in the sodium chloride concentration of the tubular fluid at the macula densa. Single juxtaglomerular apparatuses were microdissected from rabbits and the tubule segment containing the macula densa was perfused, while simultaneously the entire juxtaglomerular apparatus was superfused, and the fluid was collected for renin measurement. In this preparation, in which influences from renal nerves and local hemodynamic effects are eliminated, a decrease in the tubular sodium chloride concentration at the macula densa results in a prompt stimulation of the renin release rate.


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