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Science 25 September 1987:
Vol. 237. no. 4822, pp. 1610 - 1614
DOI: 10.1126/science.3629259
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Articles

Science, Vol 237, Issue 4822, 1610-1614
Copyright © 1987 by American Association for the Advancement of Science

articles

Identification of a novel thyroid hormone receptor expressed in the mammalian central nervous system

CC Thompson, C Weinberger, R Lebo, and RM Evans

A complementary DNA clone derived from rat brain messenger RNA has been isolated on the basis of homology to the human thyroid hormone receptor gene. Expression of this complementary DNA produces a high-affinity binding protein for thyroid hormones. Sequence analysis and the mapping of this gene to a distinct human genetic locus indicate the existence of multiple human thyroid hormone receptors. Messenger RNA from this gene is expressed in a tissue-specific fashion with highest levels in the central nervous system.


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