Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Site Tools

  • AAAS
  • Subscribe
  • Feedback

Site Search

Search Advanced

Science 25 September 1987:
Vol. 237. no. 4822, pp. 1588 - 1595
DOI: 10.1126/science.3629258
Prev | Table of Contents | Next

Articles

Science, Vol 237, Issue 4822, 1588-1595
Copyright © 1987 by American Association for the Advancement of Science

articles

Biomaterial-centered infection: microbial adhesion versus tissue integration

AG Gristina

Biomaterials are being used with increasing frequency for tissue substitution. Complex devices such as total joint replacements and the total artificial heart represent combinations of polymers and metal alloys for system and organ replacement. The major barriers to the extended use of these devices are the possibility of bacterial adhesion to biomaterials, which causes biomaterial-centered infection, and the lack of successful tissue integration or compatibility with biomaterial surfaces. Interactions of biomaterials with bacteria and tissue cells are directed not only by specific receptors and outer membrane molecules on the cell surface, but also by the atomic geometry and electronic state of the biomaterial surface. An understanding of these mechanisms is important to all fields of medicine and is derived from and relevant to studies in microbiology, biochemistry, and physics. Modifications to biomaterial surfaces at an atomic level will allow the programming of cell-to-substratum events, thereby diminishing infection by enhancing tissue compatibility or integration, or by directly inhibiting bacterial adhesion.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Molecular biomimetics: nanotechnology and bionanotechnology using genetically engineered peptides.
C. Tamerler and M. Sarikaya (2009)
Phil Trans R Soc A 367, 1705-1726
   Abstract »    Full Text »    PDF »
Catheter associated urinary tract infection: what is it, what causes it and how can we prevent it?.
J. Elvy and A. Colville (2009)
Journal of Infection Prevention 10, 36-41
   Abstract »    PDF »
Influence of surface porosity and pH on bacterial adherence to hydroxyapatite and biphasic calcium phosphate bioceramics.
T. J. Kinnari, J. Esteban, N. Z. Martin-de-Hijas, O. Sanchez-Munoz, S. Sanchez-Salcedo, M. Colilla, M. Vallet-Regi, and E. Gomez-Barrena (2009)
J. Med. Microbiol. 58, 132-137
   Abstract »    Full Text »    PDF »
Bacterial colonization of polymer brush-coated and pristine silicone rubber implanted in infected pockets in mice.
M. R. Nejadnik, A. F. Engelsman, I. C. Saldarriaga Fernandez, H. J. Busscher, W. Norde, and H. C. van der Mei (2008)
J. Antimicrob. Chemother. 62, 1323-1325
   Abstract »    Full Text »    PDF »
One stage uncemented revision of infected total hip replacement using cancellous allograft bone impregnated with antibiotics.
H. Winkler, A. Stoiber, K. Kaudela, F. Winter, and F. Menschik (2008)
J Bone Joint Surg Br 90-B, 1580-1584
   Abstract »    Full Text »    PDF »
Microbial Biofilms in Ophthalmology and Infectious Disease.
I. Behlau and M. S. Gilmore (2008)
Arch Ophthalmol 126, 1572-1581
   Abstract »    Full Text »    PDF »
What other biologic and mechanical factors might contribute to osteolysis?.
E. M. Greenfield and J. Bechtold (2008)
J. Am. Acad. Ortho. Surg. 16, S56-S62
   Abstract »    Full Text »    PDF »
Impact of Pseudomonas aeruginosa quorum sensing on biofilm persistence in an in vivo intraperitoneal foreign-body infection model.
L. D. Christensen, C. Moser, P. O. Jensen, T. B. Rasmussen, L. Christophersen, S. Kjelleberg, N. Kumar, N. Hoiby, M. Givskov, and T. Bjarnsholt (2007)
Microbiology 153, 2312-2320
   Abstract »    Full Text »    PDF »
Fluorescence-Based Bacterial Overlay Method for Simultaneous In Situ Quantification of Surface-Attached Bacteria.
R. Muller, G. Groger, K.-A. Hiller, G. Schmalz, and S. Ruhl (2007)
Appl. Envir. Microbiol. 73, 2653-2660
   Abstract »    Full Text »    PDF »
Weak Rolling Adhesion Enhances Bacterial Surface Colonization.
B. N. Anderson, A. M. Ding, L. M. Nilsson, K. Kusuma, V. Tchesnokova, V. Vogel, E. V. Sokurenko, and W. E. Thomas (2007)
J. Bacteriol. 189, 1794-1802
   Abstract »    Full Text »    PDF »
Effective Prevention of Microbial Biofilm Formation on Medical Devices by Low-Energy Surface Acoustic Waves.
Z. Hazan, J. Zumeris, H. Jacob, H. Raskin, G. Kratysh, M. Vishnia, N. Dror, T. Barliya, M. Mandel, and G. Lavie (2006)
Antimicrob. Agents Chemother. 50, 4144-4152
   Abstract »    Full Text »    PDF »
Antibiotic-Loaded Bone Cement for Infection Prophylaxis in Total Joint Replacement.
W. A. Jiranek, A. D. Hanssen, and A. S. Greenwald (2006)
J. Bone Joint Surg. Am. 88, 2487-2500
   Abstract »    Full Text »    PDF »
Bacterial factors influencing adhesion of Pseudomonas aeruginosa strains to a poly(ethylene oxide) brush..
A. Roosjen, H. J. Busscher, W. Norde, and H. C. van der Mei (2006)
Microbiology 152, 2673-2682
   Abstract »    Full Text »    PDF »
Microbial Adhesion in Flow Displacement Systems.
H. J. Busscher and H. C. van der Mei (2006)
Clin. Microbiol. Rev. 19, 127-141
   Abstract »    Full Text »    PDF »
Vancomycin-Resistant Enterococcus faecium: Catheter Colonization, esp Gene, and Decreased Susceptibility to Antibiotics in Biofilm.
I. I. Raad, H. A. Hanna, M. Boktour, G. Chaiban, R. Y. Hachem, T. Dvorak, R. Lewis, and B. E. Murray (2005)
Antimicrob. Agents Chemother. 49, 5046-5050
   Abstract »    Full Text »    PDF »
Thermal Characterizations of Silver-containing Bioactive Glass-coated Sutures.
J. J. Blaker, A. R. Boccaccini, and S. N. Nazhat (2005)
J Biomater Appl 20, 81-98
   Abstract »    PDF »
Antimicrobial efficacy of a new antibiotic-loaded poly(hydroxybutyric-co-hydroxyvaleric acid) controlled release system.
S. Rossi, A. O. Azghani, and A. Omri (2004)
J. Antimicrob. Chemother. 54, 1013-1018
   Abstract »    Full Text »    PDF »
Prosthetic-Joint Infections.
W. Zimmerli, A. Trampuz, and P. E. Ochsner (2004)
N. Engl. J. Med. 351, 1645-1654
   Full Text »    PDF »
Nanoscale Investigation of Pathogenic Microbial Adhesion to a Biomaterial.
R. J. Emerson IV and T. A. Camesano (2004)
Appl. Envir. Microbiol. 70, 6012-6022
   Abstract »    Full Text »    PDF »
Effect of subinhibitory concentration of piperacillin/tazobactam on Pseudomonas aeruginosa.
A. P. Fonseca, C. Extremina, A. F. Fonseca, and J. C. Sousa (2004)
J. Med. Microbiol. 53, 903-910
   Abstract »    Full Text »    PDF »
Two Morphological Types of Cell Appendages on a Strongly Adhesive Bacterium, Acinetobacter sp. Strain Tol 5.
S. Ishii, J. Koki, H. Unno, and K. Hori (2004)
Appl. Envir. Microbiol. 70, 5026-5029
   Abstract »    Full Text »    PDF »
In Vitro Attachment of Staphylococcus Epidermidis to Surgical Sutures with and without Ag-Containing Bioactive Glass Coating.
J. Pratten, S. N. Nazhat, J. J. Blaker, and A. R. Boccaccini (2004)
J Biomater Appl 19, 47-57
   Abstract »    PDF »
Caspofungin modulates in vitro adherence of Candida albicans to plastic coated with extracellular matrix proteins.
J. Soustre, M.-H. Rodier, S. Imbert-Bouyer, G. Daniault, and C. Imbert (2004)
J. Antimicrob. Chemother. 53, 522-525
   Abstract »    Full Text »    PDF »
Inhibition of adhesion of yeasts and bacteria by poly(ethylene oxide)-brushes on glass in a parallel plate flow chamber.
A. Roosjen, H. J. Kaper, H. C. van der Mei, W. Norde, and H. J. Busscher (2003)
Microbiology 149, 3239-3246
   Abstract »    Full Text »    PDF »
Role of Capsular Colanic Acid in Adhesion of Uropathogenic Escherichia coli.
A. Hanna, M. Berg, V. Stout, and A. Razatos (2003)
Appl. Envir. Microbiol. 69, 4474-4481
   Abstract »    Full Text »    PDF »
Development and Future of Gastroplasties for Morbid Obesity.
E. E. Mason (2003)
Arch Surg 138, 361-366
   Full Text »    PDF »
Measurement of Adhesive Forces between Individual Staphylococcus aureus MSCRAMMs and Protein-Coated Surfaces by Use of Optical Tweezers.
K. H. Simpson, G. Bowden, M. Hook, and B. Anvari (2003)
J. Bacteriol. 185, 2031-2035
   Abstract »    Full Text »    PDF »
Antibacterial poly(D,L-lactic acid) coating of medical implants using a biodegradable drug delivery technology.
H. Gollwitzer, K. Ibrahim, H. Meyer, W. Mittelmeier, R. Busch, and A. Stemberger (2003)
J. Antimicrob. Chemother. 51, 585-591
   Abstract »    Full Text »    PDF »
Broad-Spectrum Bactericidal Activity of Ag2O-Doped Bioactive Glass.
M. Bellantone, H. D. Williams, and L. L. Hench (2002)
Antimicrob. Agents Chemother. 46, 1940-1945
   Abstract »    Full Text »    PDF »
Bacterial Adhesion: Seen Any Good Biofilms Lately?.
W. M. Dunne Jr. (2002)
Clin. Microbiol. Rev. 15, 155-166
   Abstract »    Full Text »    PDF »
Reversal of Flagellar Rotation Is Important in Initial Attachment of Escherichia coli to Glass in a Dynamic System with High- and Low-Ionic-Strength Buffers.
J. W. McClaine and R. M. Ford (2002)
Appl. Envir. Microbiol. 68, 1280-1289
   Abstract »    Full Text »    PDF »
Late Hematogenous Infection of Subcutaneous Implants in Rats.
B. Gottenbos, F. Klatter, H. C. Van Der Mei, H. J. Busscher, and P. Nieuwenhuis (2001)
Clin. Vaccine Immunol. 8, 980-983
   Abstract »    Full Text »    PDF »
Antimicrobial effects of positively charged surfaces on adhering Gram-positive and Gram-negative bacteria.
B. Gottenbos, D. W. Grijpma, H. C. van der Mei, J. Feijen, and H. J. Busscher (2001)
J. Antimicrob. Chemother. 48, 7-13
   Abstract »    Full Text »    PDF »
Adhesion of Pseudomonas fluorescens (ATCC 17552) to Nonpolarized and Polarized Thin Films of Gold.
J. P. Busalmen and S. R. de Sanchez (2001)
Appl. Envir. Microbiol. 67, 3188-3194
   Abstract »    Full Text »    PDF »
Matrix polymers of Candida biofilms and their possible role in biofilm resistance to antifungal agents.
G. S. Baillie and L. J. Douglas (2000)
J. Antimicrob. Chemother. 46, 397-403
   Abstract »    Full Text »    PDF »
Pathophysiology of Infections After Internal Fixation of Fractures.
A. H. Schmidt and M. F. Swiontkowski (2000)
J. Am. Acad. Ortho. Surg. 8, 285-291
   Abstract »    Full Text »    PDF »
Control of Staphylococcal Adhesion to Polymethylmethacrylate and Enhancement of Susceptibility to Antibiotics by Poloxamer 407.
M.-L. Veyries, F. Faurisson, M.-L. Joly-Guillou, and B. Rouveix (2000)
Antimicrob. Agents Chemother. 44, 1093-1096
   Abstract »    Full Text »
Closer to nature: new biomaterials and tissue engineering in ophthalmology.
B. ALLAN (1999)
Br. J. Ophthalmol. 83, 1235-1240
   Full Text »
Localized, Positive Charge Mediates Adhesion of Rhodosporidium toruloides to Barley Leaves and Polystyrene.
J. W. Buck and J. H. Andrews (1999)
Appl. Envir. Microbiol. 65, 2179-2183
   Abstract »    Full Text »
Characterization of Staphylococcus epidermidis Polysaccharide Intercellular Adhesin/Hemagglutinin in the Pathogenesis of Intravascular Catheter-Associated Infection in a Rat Model.
M. E. Rupp, J. S. Ulphani, P. D. Fey, and D. Mack (1999)
Infect. Immun. 67, 2656-2659
   Abstract »    Full Text »    PDF »
Defensins Impair Phagocytic Killing by Neutrophils in Biomaterial-Related Infection.
S. S. Kaplan, R. P. Heine, and R. L. Simmons (1999)
Infect. Immun. 67, 1640-1645
   Abstract »    Full Text »    PDF »
Molecular determinants of bacterial adhesion monitored by atomic force microscopy.
A. Razatos, Y.-L. Ong, M. M. Sharma, and G. Georgiou (1998)
PNAS 95, 11059-11064
   Abstract »    Full Text »    PDF »
Effect of Growth Rate on Resistance of Candida albicans Biofilms to Antifungal Agents.
G. S. Baillie and L. J. Douglas (1998)
Antimicrob. Agents Chemother. 42, 1900-1905
   Abstract »    Full Text »
Instructional Course Lectures, The American Academy of Orthopaedic Surgeons - Evaluation and Treatment of Infection at the Site of a Total Hip or Knee Arthroplasty*{{dagger}}.
A. D. HANSSEN and J. A. RAND (1998)
J. Bone Joint Surg. Am. 80, 910-22
   Full Text »
Role of Rifampin for Treatment of Orthopedic Implant-Related Staphylococcal Infections: A Randomized Controlled Trial.
W. Zimmerli, A. F. Widmer, M. Blatter, R. Frei, P. E. Ochsner, and for the Foreign-Body Infection Study Group (1998)
JAMA 279, 1537-1541
   Abstract »    Full Text »    PDF »
Outpatient Parenteral Antimicrobial-Drug Therapy.
D. N. Gilbert, R. J. Dworkin, S. R. Raber, and J. E. Leggett (1997)
N. Engl. J. Med. 337, 829-839
   Full Text »    PDF »
In Vitro Response of Escherichia Coli to Antibiotics and Ultrasound at Various Insonation Intensities.
R. G. Williams and W. G. Pitt (1997)
J Biomater Appl 12, 20-30
   Abstract »    PDF »
Physico-Chemical Interactions in Initial Microbial Adhesion and Relevance for Biofilm Formation.
H.J. Busscher and H.C. Van Der Mei (1997)
Advances in Dental Research 11, 24-32
   Abstract »    PDF »
Development of a non-pulsatile permanent rotary blood pump.
Y. Nose and K. Kawahito (1997)
Eur. J. Cardiothorac. Surg. 11, S32-S38
   Abstract »    PDF »
Small Caliber Vascular Grafts. Part I: State of the Art.
R. J. Zdrahala (1996)
J Biomater Appl 10, 309-329
   Abstract »    PDF »
Instructional Course Lectures, The American Academy of Orthopaedic Surgeons - Prevention of Deep Periprosthetic Joint Infection*{{dagger}}.
A. D. HANSSEN, D. R. OSMON, and C. L. NELSON (1996)
J. Bone Joint Surg. Am. 78, 458-71
   Full Text »
Infections During Extended Circulatory Support: University of Alabama at Birmingham Experience 1989 to 1994.
W. L. Holman, C. P. Murrah, E. R. Ferguson, R. C. Bourge, D. C. McGiffin, and J. K. Kirklin (1996)
Ann. Thorac. Surg. 61, 366-371
   Abstract »    Full Text »
Development of Silastic Polyurethane (Angioflex) Materials with Antibacterial Agent.
K. Rathinam, P. R. Hari, C. P. Sharma, and J. Shanmugam (1996)
J Biomater Appl 10, 210-216
   Abstract »    PDF »
Spinal Osteomyelitis After TPN Catheter-Induced Septicemia.
F. A. Corso, D. B. Shaul, and B. M. Wolfe (1995)
JPEN J Parenter Enteral Nutr 19, 291-295
   Abstract »    PDF »
Saliva-Bacterium Interactions in Oral Microbial Ecology.
F. A. Scannapieco (1994)
Critical Reviews in Oral Biology & Medicine 5, 203-248
   Abstract »    Full Text »    PDF »
Microbiology of the Dental Implant.
A. Mombelli (1993)
Advances in Dental Research 7, 202-206
   Abstract »    PDF »
Biological Interactions: Causes for Risks and Failures of Biomaterials and Devices.
M. Jayabalan (1993)
J Biomater Appl 8, 64-71
   Abstract »    PDF »
Risk Factors for Infusion-related Phlebitis with Small Peripheral Venous Catheters: A Randomized Controlled Trial.
D. G. Maki and M. Ringer (1991)
Ann Intern Med 114, 845-854
   Abstract »    PDF »
Photochemical Coatings for the Prevention of Bacterial Colonization.
S.G. Dunkirk, S.L. Gregg, L.W. Duran, J.D. Monfils, J.E. Haapala, J.A. Marcy, D.L. Clapper, R.A. Amos, and P.E. Guire (1991)
J Biomater Appl 6, 131-156
   Abstract »    PDF »
Risk Factors for Nosocomial Infection in Intensive Care: 'Devices vs Nature' and Goals for the Next Decade.
W. SHAKESPEARE and D. G. MAKI (1989)
Arch Intern Med 149, 30-35
   Abstract »    PDF »
Biomaterials and biomedical devices.
J. Hanker and B. Giammara (1988)
Science 242, 885-892
   Abstract »    PDF »
FOREIGN-BODY INFECTIONS.
(1987)
Journal Watch (General) 1987, 7
   Full Text »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)