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Science 11 September 1987:
Vol. 237. no. 4820, pp. 1333 - 1336
DOI: 10.1126/science.2442813
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Articles

Science, Vol 237, Issue 4820, 1333-1336
Copyright © 1987 by American Association for the Advancement of Science

articles

Accelerated healing of incisional wounds in rats induced by transforming growth factor-beta

TA Mustoe, GF Pierce, A Thomason, P Gramates, MB Sporn, and TF Deuel

The role of polypeptide growth factors in the processes of inflammation and repair was investigated by analyzing the influence of transforming growth factor-beta (TGF-beta), applied directly to linear incisions made through rat dorsal skin. A dose-dependent, direct stimulatory effect of a single application of TGF-beta on the breaking strength of healing incisional wounds was demonstrated. An increase in maximum wound strength of 220 percent of control was observed at 5 days; the healing rate was accelerated by approximately 3 days for at least 14 days after production of the wound and application of TGF-beta. These increases in wound strength were accompanied by an increased influx of mononuclear cells and fibroblasts and by marked increases in collagen deposition at the site of application of TGF-beta. TGF-beta is thus a potent pharmacologic agent that can accelerate wound healing in rats.


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