Science 4 September 1987: Vol. 237. no. 4819, pp. 1219 - 1223 DOI: 10.1126/science.2820058

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Articles

Lack of Cocaine Self-Administration in Mice Expressing a Cocaine-Insensitive Dopamine Transporter.

M. Thomsen, D. D. Han, H. H. Gu, and S. B. Caine (2009)
J. Pharmacol. Exp. Ther. 331, 204-211
 |  Abstract »  |  Full Text »  |  PDF »

Combinations of Cocaine with Other Dopamine Uptake Inhibitors: Assessment of Additivity.

G. Tanda, A. H. Newman, A. L. Ebbs, V. Tronci, J. L. Green, R. J. Tallarida, and J. L. Katz (2009)
J. Pharmacol. Exp. Ther. 330, 802-809
 |  Abstract »  |  Full Text »  |  PDF »

Mechanisms of Disulfiram-induced Cocaine Abstinence: Antabuse and Cocaine Relapse.

M. Gaval-Cruz and D. Weinshenker (2009)
Mol. Interv. 9, 175-187
 |  Abstract »  |  Full Text »  |  PDF »

Assessment of Reinforcing Effects of Benztropine Analogs and Their Effects on Cocaine Self-Administration in Rats: Comparisons with Monoamine Uptake Inhibitors.

T. Hiranita, P. L. Soto, A. H. Newman, and J. L. Katz (2009)
J. Pharmacol. Exp. Ther. 329, 677-686
 |  Abstract »  |  Full Text »  |  PDF »

Cocaine Alters Vesicular Dopamine Sequestration and Potassium-Stimulated Dopamine Release: The Role of D2 Receptor Activation.

S. J. Farnsworth, T. J. Volz, G. R. Hanson, and A. E. Fleckenstein (2009)
J. Pharmacol. Exp. Ther. 328, 807-812
 |  Abstract »  |  Full Text »  |  PDF »

Dramatically Decreased Cocaine Self-Administration in Dopamine But Not Serotonin Transporter Knock-Out Mice.

M. Thomsen, F. S. Hall, G. R. Uhl, and S. B. Caine (2009)
J. Neurosci. 29, 1087-1092
 |  Abstract »  |  Full Text »  |  PDF »

Modes and Mishaps of Neuronal Migration in the Mammalian Brain.

C. Metin, R. B. Vallee, P. Rakic, and P. G. Bhide (2008)
J. Neurosci. 28, 11746-11752
 |  Abstract »  |  Full Text »  |  PDF »

Positron emission tomography imaging studies of dopamine receptors in primate models of addiction.

M. A Nader, P. W Czoty, R. W Gould, and N. V Riddick (2008)
Phil Trans R Soc B 363, 3223-3232
 |  Abstract »  |  Full Text »  |  PDF »

Mechanism and Time Course of Cocaine-Induced Long-Term Potentiation in the Ventral Tegmental Area.

E. Argilli, D. R. Sibley, R. C. Malenka, P. M. England, and A. Bonci (2008)
J. Neurosci. 28, 9092-9100
 |  Abstract »  |  Full Text »  |  PDF »

In Vivo Characterization of a Novel Phenylisothiocyanate Tropane Analog at Monoamine Transporters in Rat Brain.

V. Murthy, T. J. Martin, S. Kim, H. M. L. Davies, and S. R. Childers (2008)
J. Pharmacol. Exp. Ther. 326, 587-595
 |  Abstract »  |  Full Text »  |  PDF »

Cocaine-Conditioned Place Preference by Dopamine-Deficient Mice Is Mediated by Serotonin.

T. S. Hnasko, B. N. Sotak, and R. D. Palmiter (2007)
J. Neurosci. 27, 12484-12488
 |  Abstract »  |  Full Text »  |  PDF »

PET Studies of d-Methamphetamine Pharmacokinetics in Primates: Comparison with l-Methamphetamine and ( )-Cocaine.

J. S. Fowler, C. Kroll, R. Ferrieri, D. Alexoff, J. Logan, S. L. Dewey, W. Schiffer, D. Schlyer, P. Carter, P. King, et al. (2007)
J. Nucl. Med. 48, 1724-1732
 |  Abstract »  |  Full Text »  |  PDF »

Applicability of the Dopamine and Rate Hypotheses in Explaining the Differences in Behavioral Pharmacology of the Chloro-Benztropine Analogs: Studies Conducted Using Intracerebral Microdialysis and Population Pharmacodynamic Modeling.

A. A. Othman, A. H. Newman, and N. D. Eddington (2007)
J. Pharmacol. Exp. Ther. 322, 760-769
 |  Abstract »  |  Full Text »  |  PDF »

GPR37 associates with the dopamine transporter to modulate dopamine uptake and behavioral responses to dopaminergic drugs.

D. Marazziti, S. Mandillo, C. Di Pietro, E. Golini, R. Matteoni, and G. P. Tocchini-Valentini (2007)
PNAS 104, 9846-9851
 |  Abstract »  |  Full Text »  |  PDF »

Effects of Two Novel D3-Selective Compounds, NGB 2904 [N-(4-(4-(2,3-Dichlorophenyl)piperazin-1-yl)butyl)-9H-fluorene-2-carboxamide] and CJB 090 [N-(4-(4-(2,3-Dichlorophenyl)piperazin-1-yl)butyl)-4-(pyridin-2-yl)benzamide], on the Reinforcing and Discriminative Stimulus Effects of Cocaine in Rhesus Monkeys.

J. L. Martelle, R. Claytor, J. T. Ross, B. A. Reboussin, A. H. Newman, and M. A. Nader (2007)
J. Pharmacol. Exp. Ther. 321, 573-582
 |  Abstract »  |  Full Text »  |  PDF »

Absence of dopamine D2 receptors unmasks an inhibitory control over the brain circuitries activated by cocaine.

M. Welter, D. Vallone, T. A. Samad, H. Meziane, A. Usiello, and E. Borrelli (2007)
PNAS 104, 6840-6845
 |  Abstract »  |  Full Text »  |  PDF »

Localization of Cocaine Analog [125I]RTI 82 Irreversible Binding to Transmembrane Domain 6 of the Dopamine Transporter.

R. A. Vaughan, D. S. Sakrikar, M. L. Parnas, S. Adkins, J. D. Foster, R. A. Duval, J. R. Lever, S. S. Kulkarni, and A. Hauck-Newman (2007)
J. Biol. Chem. 282, 8915-8925
 |  Abstract »  |  Full Text »  |  PDF »

Effects of Combined Dopamine and Serotonin Transporter Inhibitors on Cocaine Self-Administration in Rhesus Monkeys.

L. L. Howell, F. I. Carroll, J. R. Votaw, M. M. Goodman, and H. L. Kimmel (2007)
J. Pharmacol. Exp. Ther. 320, 757-765
 |  Abstract »  |  Full Text »  |  PDF »

New Medication Strategies for Comorbid Substance Use and Bipolar Affective Disorders.

T. R. Kosten and T. A. Kosten (2007)
Focus 5, 262-269
 |  Abstract »  |  Full Text »  |  PDF »

Transport, Metabolism, and in Vivo Population Pharmacokinetics of the Chloro Benztropine Analogs, a Class of Compounds Extensively Evaluated in Animal Models of Drug Abuse.

A. A. Othman, S. A. Syed, A. H. Newman, and N. D. Eddington (2007)
J. Pharmacol. Exp. Ther. 320, 344-353
 |  Abstract »  |  Full Text »  |  PDF »

Cocaine Increases the Intracellular Calcium Concentration in Brain Independently of Its Cerebrovascular Effects..

C. Du, M. Yu, N. D. Volkow, A. P. Koretsky, J. S. Fowler, and H. Benveniste (2006)
J. Neurosci. 26, 11522-11531
 |  Abstract »  |  Full Text »  |  PDF »

Abolished cocaine reward in mice with a cocaine-insensitive dopamine transporter.

R. Chen, M. R. Tilley, H. Wei, F. Zhou, F.-M. Zhou, S. Ching, N. Quan, R. L. Stephens, E. R. Hill, T. Nottoli, et al. (2006)
PNAS 103, 9333-9338
 |  Abstract »  |  Full Text »  |  PDF »

A dopamine transporter gene functional variant associated with cocaine abuse in a Brazilian sample.

C. Guindalini, M. Howard, K. Haddley, R. Laranjeira, D. Collier, N. Ammar, I. Craig, C. O'Gara, V. J. Bubb, T. Greenwood, et al. (2006)
PNAS 103, 4552-4557
 |  Abstract »  |  Full Text »  |  PDF »

Cocaine-induced dendritic spine formation in D1 and D2 dopamine receptor-containing medium spiny neurons in nucleus accumbens.

K.-W. Lee, Y. Kim, A. M. Kim, K. Helmin, A. C. Nairn, and P. Greengard (2006)
PNAS 103, 3399-3404
 |  Abstract »  |  Full Text »  |  PDF »

Relationship between in Vivo Occupancy at the Dopamine Transporter and Behavioral Effects of Cocaine, GBR 12909 [1-{2-[Bis-(4-fluorophenyl)methoxy]ethyl}-4-(3-phenylpropyl)piperazine], and Benztropine Analogs.

R. I. Desai, T. A. Kopajtic, D. French, A. H. Newman, and J. L. Katz (2005)
J. Pharmacol. Exp. Ther. 315, 397-404
 |  Abstract »  |  Full Text »  |  PDF »

Medication Development for Addictive Disorders: The State of the Science.

F. J. Vocci, J. Acri, and A. Elkashef (2005)
Am J Psychiatry 162, 1432-1440
 |  Abstract »  |  Full Text »  |  PDF »

PET Imaging of Dopamine D2 Receptors in Monkey Models of Cocaine Abuse: Genetic Predisposition Versus Environmental Modulation.

M. A. Nader and P. W. Czoty (2005)
Am J Psychiatry 162, 1473-1482
 |  Abstract »  |  Full Text »  |  PDF »

Neurochemical and Behavioral Responses to Cocaine in Adult Male Rats with Neonatal Isolation Experience.

T. A. Kosten, X. Y. Zhang, and P. Kehoe (2005)
J. Pharmacol. Exp. Ther. 314, 661-667
 |  Abstract »  |  Full Text »  |  PDF »

Recognition of Benztropine by the Dopamine Transporter (DAT) Differs from That of the Classical Dopamine Uptake Inhibitors Cocaine, Methylphenidate, and Mazindol as a Function of a DAT Transmembrane 1 Aspartic Acid Residue.

O. T. Ukairo, C. D. Bondi, A. H. Newman, S. S. Kulkarni, A. P. Kozikowski, S. Pan, and C. K. Surratt (2005)
J. Pharmacol. Exp. Ther. 314, 575-583
 |  Abstract »  |  Full Text »  |  PDF »

Expression of Mutant NMDA Receptors in Dopamine D1 Receptor-Containing Cells Prevents Cocaine Sensitization and Decreases Cocaine Preference.

C. L. Heusner and R. D. Palmiter (2005)
J. Neurosci. 25, 6651-6657
 |  Abstract »  |  Full Text »  |  PDF »

Acute and Chronic Corticotropin-Releasing Factor 1 Receptor Blockade Inhibits Cocaine-Induced Dopamine Release: Correlation with Dopamine Neuron Activity.

D. J. Lodge and A. A. Grace (2005)
J. Pharmacol. Exp. Ther. 314, 201-206
 |  Abstract »  |  Full Text »  |  PDF »

Time-Dependent Changes in Receptor/G-Protein Coupling in Rat Brain following Chronic Monoamine Transporter Blockade.

K. A. O'Connor, L. J. Porrino, H. M. L. Davies, and S. R. Childers (2005)
J. Pharmacol. Exp. Ther. 313, 510-517
 |  Abstract »  |  Full Text »  |  PDF »

Relationship between the Serotonergic Activity and Reinforcing Effects of a Series of Amphetamine Analogs.

S. Wee, K. G. Anderson, M. H. Baumann, R. B. Rothman, B. E. Blough, and W. L. Woolverton (2005)
J. Pharmacol. Exp. Ther. 313, 848-854
 |  Abstract »  |  Full Text »  |  PDF »

Effects of 4'-Chloro-3{alpha}-(diphenylmethoxy)-tropane on Mesostriatal, Mesocortical, and Mesolimbic Dopamine Transmission: Comparison with Effects of Cocaine.

G. Tanda, A. Ebbs, A. H. Newman, and J. L. Katz (2005)
J. Pharmacol. Exp. Ther. 313, 613-620
 |  Abstract »  |  Full Text »  |  PDF »

Identification of a Dopamine Transporter Ligand That Blocks the Stimulant Effects of Cocaine.

R. I. Desai, T. A. Kopajtic, M. Koffarnus, A. H. Newman, and J. L. Katz (2005)
J. Neurosci. 25, 1889-1893
 |  Abstract »  |  Full Text »  |  PDF »

Gene Transfer of Cocaine Hydrolase Suppresses Cardiovascular Responses to Cocaine in Rats.

Y. Gao, E. Atanasova, N. Sui, J. D. Pancook, J. D. Watkins, and S. Brimijoin (2005)
Mol. Pharmacol. 67, 204-211
 |  Abstract »  |  Full Text »  |  PDF »

Addiction as a Computational Process Gone Awry.

A. D. Redish (2004)
Science 306, 1944-1947
 |  Abstract »  |  Full Text »  |  PDF »

Reinforcing, subject-rated, performance and physiological effects of methylphenidate and d-amphetamine in stimulant abusing humans.

W. W. Stoops, P. E.A. Glaser, M. T. Fillmore, and C. R. Rush (2004)
J Psychopharmacol 18, 534-543
 |  Abstract »  |  PDF »

Evidence That Methylphenidate Enhances the Saliency of a Mathematical Task by Increasing Dopamine in the Human Brain.

N. D. Volkow, G.-J. Wang, J. S. Fowler, F. Telang, L. Maynard, J. Logan, S. J. Gatley, N. Pappas, C. Wong, P. Vaska, et al. (2004)
Am J Psychiatry 161, 1173-1180
 |  Abstract »  |  Full Text »  |  PDF »

Effects of Dopamine Transporter Inhibitors on Cocaine Self-Administration in Rhesus Monkeys: Relationship to Transporter Occupancy Determined by Positron Emission Tomography Neuroimaging.

K. P. Lindsey, K. M. Wilcox, J. R. Votaw, M. M. Goodman, C. Plisson, F. I. Carroll, K. C. Rice, and L. L. Howell (2004)
J. Pharmacol. Exp. Ther. 309, 959-969
 |  Abstract »  |  Full Text »  |  PDF »

Methylphenidate Restores Ventral Tegmental Area Dopamine Neuron Activity in Prenatal Ethanol-Exposed Rats by Augmenting Dopamine Neurotransmission.

K.-C. Choong and R.-Y. Shen (2004)
J. Pharmacol. Exp. Ther. 309, 444-451
 |  Abstract »  |  Full Text »  |  PDF »

Cocaine Self-Administration Produces a Progressive Involvement of Limbic, Association, and Sensorimotor Striatal Domains.

L. J. Porrino, D. Lyons, H. R. Smith, J. B. Daunais, and M. A. Nader (2004)
J. Neurosci. 24, 3554-3562
 |  Abstract »  |  Full Text »  |  PDF »

Discrete Cell Gene Profiling of Ventral Tegmental Dopamine Neurons after Acute and Chronic Cocaine Self-Administration.

E. Backes and S. E. Hemby (2003)
J. Pharmacol. Exp. Ther. 307, 450-459
 |  Abstract »  |  Full Text »  |  PDF »

Evaluation of the Blood-Brain Barrier Transport, Population Pharmacokinetics, and Brain Distribution of Benztropine Analogs and Cocaine Using in Vitro and in Vivo Techniques.

S. Raje, J. Cao, A. H. Newman, H. Gao, and N. D. Eddington (2003)
J. Pharmacol. Exp. Ther. 307, 801-808
 |  Abstract »  |  Full Text »  |  PDF »

Involvement of the Olfactory Tubercle in Cocaine Reward: Intracranial Self-Administration Studies.

S. Ikemoto (2003)
J. Neurosci. 23, 9305-9311
 |  Abstract »  |  Full Text »  |  PDF »

The Reinforcing Efficacy of Psychostimulants in Rhesus Monkeys: The Role of Pharmacokinetics and Pharmacodynamics.

J. A. Lile, Z. Wang, W. L. Woolverton, J. E. France, T. C. Gregg, H. M. L. Davies, and M. A. Nader (2003)
J. Pharmacol. Exp. Ther. 307, 356-366
 |  Abstract »  |  Full Text »  |  PDF »

Differential Changes in Signal and Background Firing of Accumbal Neurons During Cocaine Self-Administration.

L. L. Peoples and D. Cavanaugh (2003)
J Neurophysiol 90, 993-1010
 |  Abstract »  |  Full Text »  |  PDF »

Phosphatidylinositol 3-Kinase, Protein Kinase C, and MEK1/2 Kinase Regulation of Dopamine Transporters (DAT) Require N-terminal DAT Phosphoacceptor Sites.

Z. Lin, P.-W. Zhang, X. Zhu, J.-M. Melgari, R. Huff, R. L. Spieldoch, and G. R. Uhl (2003)
J. Biol. Chem. 278, 20162-20170
 |  Abstract »  |  Full Text »  |  PDF »

sigma 1 Receptor-Related Neuroactive Steroids Modulate Cocaine-Induced Reward.

P. Romieu, R. Martin-Fardon, W. D. Bowen, and T. Maurice (2003)
J. Neurosci. 23, 3572-3576
 |  Abstract »  |  Full Text »  |  PDF »

Characterization of a Functional Bacterial Homologue of Sodium-dependent Neurotransmitter Transporters.

A. Androutsellis-Theotokis, N. R. Goldberg, K. Ueda, T. Beppu, M. L. Beckman, S. Das, J. A. Javitch, and G. Rudnick (2003)
J. Biol. Chem. 278, 12703-12709
 |  Abstract »  |  Full Text »  |  PDF »

Cocaine Abusers Have an Overexpression of alpha -Synuclein in Dopamine Neurons.

D. C. Mash, Q. Ouyang, J. Pablo, M. Basile, S. Izenwasser, A. Lieberman, and R. J. Perrin (2003)
J. Neurosci. 23, 2564-2571
 |  Abstract »  |  Full Text »  |  PDF »

Mixed Cocaine Agonist/Antagonist Properties of (+)-Methyl 4beta -(4-Chlorophenyl)-1-methylpiperidine-3alpha -carboxylate, a Piperidine-Based Analog of Cocaine.

A. P. Kozikowski, K. M. Johnson, O. Deschaux, B. C. Bandyopadhyay, G. L. Araldi, G. Carmona, P. Munzar, M. P. Smith, R. L. Balster, P. M. Beardsley, et al. (2003)
J. Pharmacol. Exp. Ther. 305, 143-150
 |  Abstract »  |  Full Text »

Cocaine Affinity Decreased by Mutations of Aromatic Residue Phenylalanine 105 in the Transmembrane Domain 2 of Dopamine Transporter.

X. Wu and H. H. Gu (2003)
Mol. Pharmacol. 63, 653-658
 |  Abstract »  |  Full Text »  |  PDF »

Substance P Depresses Excitatory Synaptic Transmission in the Nucleus Accumbens Through Dopaminergic and Purinergic Mechanisms.

S. B. Kombian, K. V. V. Ananthalakshmi, S. S. Parvathy, and W. C. Matowe (2003)
J Neurophysiol 89, 728-737
 |  Abstract »  |  Full Text »  |  PDF »

Withdrawal from Repeated Cocaine Alters Dopamine Transporter Protein Turnover in the Rat Striatum.

H. L. Kimmel, F. I. Carroll, and M. J. Kuhar (2003)
J. Pharmacol. Exp. Ther. 304, 15-21
 |  Abstract »  |  Full Text »  |  PDF »

Chronic Cocaine Self-Administration Upregulates the Norepinephrine Transporter and Alters Functional Activity in the Bed Nucleus of the Stria Terminalis of the Rhesus Monkey.

D. J. Macey, H. R. Smith, M. A. Nader, and L. J. Porrino (2003)
J. Neurosci. 23, 12-16
 |  Abstract »  |  Full Text »  |  PDF »

The Reinforcing Efficacy of the Dopamine Reuptake Inhibitor 2beta -Propanoyl-3beta -(4-tolyl)-tropane (PTT) as Measured by a Progressive-Ratio Schedule and a Choice Procedure in Rhesus Monkeys.

J. A. Lile, D. Morgan, A. M. Birmingham, Z. Wang, W. L. Woolverton, H. M. L. Davies, and M. A. Nader (2002)
J. Pharmacol. Exp. Ther. 303, 640-648
 |  Abstract »  |  Full Text »  |  PDF »

Reinforcing Strength of a Novel Dopamine Transporter Ligand: Pharmacodynamic and Pharmacokinetic Mechanisms.

W. L. Woolverton, R. Ranaldi, Z. Wang, G. A. Ordway, I. A. Paul, P. Petukhov, and A. Kozikowski (2002)
J. Pharmacol. Exp. Ther. 303, 211-217
 |  Abstract »  |  Full Text »  |  PDF »

Drug Addiction and Its Underlying Neurobiological Basis: Neuroimaging Evidence for the Involvement of the Frontal Cortex.

R. Z. Goldstein and N. D. Volkow (2002)
Am J Psychiatry 159, 1642-1652
 |  Abstract »  |  Full Text »  |  PDF »

Methylphenidate Redistributes Vesicular Monoamine Transporter-2: Role of Dopamine Receptors.

V. Sandoval, E. L. Riddle, G. R. Hanson, and A. E. Fleckenstein (2002)
J. Neurosci. 22, 8705-8710
 |  Abstract »  |  Full Text »  |  PDF »

Acute Cocaine Differentially Alters Accumbens and Striatal Dopamine Clearance in Low and High Cocaine Locomotor Responders: Behavioral and Electrochemical Recordings in Freely Moving Rats.

J. Sabeti, G. A. Gerhardt, and N. R. Zahniser (2002)
J. Pharmacol. Exp. Ther. 302, 1201-1211
 |  Abstract »  |  Full Text »  |  PDF »

Neurobehavioral Assessments of Rats Perinatally Exposed to a Commercial Mixture of Polychlorinated Biphenyls.

P. J. Bushnell, V. C. Moser, R. C. MacPhail, W. M. Oshiro, E. C. Derr-Yellin, P. M. Phillips, and P. R. S. Kodavanti (2002)
Toxicol. Sci. 68, 109-120
 |  Abstract »  |  Full Text »  |  PDF »

Biochemical and Behavioral Characterization of Novel Methylphenidate Analogs.

M. M. Schweri, H. M. Deutsch, A.T. Massey, and S. G. Holtzman (2002)
J. Pharmacol. Exp. Ther. 301, 527-535
 |  Abstract »  |  Full Text »  |  PDF »

Cerebrospinal fluid monoamine metabolites in cocaine patients: no relationship to cue-induced craving.

A. Roy, J. Berman, B. Gonzalez, and M. Roy (2002)
J Psychopharmacol 16, 227-229
 |  Abstract »  |  PDF »

Role of Dopamine D2-like Receptors in Cocaine Self-Administration: Studies with D2 Receptor Mutant Mice and Novel D2 Receptor Antagonists.

S. B. Caine, S. S. Negus, N. K. Mello, S. Patel, L. Bristow, J. Kulagowski, D. Vallone, A. Saiardi, and E. Borrelli (2002)
J. Neurosci. 22, 2977-2988
 |  Abstract »  |  Full Text »  |  PDF »

Covalent modification of proteins by cocaine.

S.-X. Deng, N. Bharat, M. C. Fischman, and D. W. Landry (2002)
PNAS 99, 3412-3416
 |  Abstract »  |  Full Text »  |  PDF »

The Pharmacokinetic Determinants of the Frequency and Pattern of Intravenous Cocaine Self-administration in Rats by Pharmacokinetic Modeling.

C. E. Lau and L. Sun (2002)
Drug Metab. Dispos. 30, 254-261
 |  Abstract »  |  Full Text »  |  PDF »

Serotonergic Attenuation of the Reinforcing and Neurochemical Effects of Cocaine in Squirrel Monkeys.

P. W. Czoty, B. C. Ginsburg, and L. L. Howell (2002)
J. Pharmacol. Exp. Ther. 300, 831-837
 |  Abstract »  |  Full Text »  |  PDF »

Interactions between Cocaine and Dopamine Agonists on Cardiovascular Function in Squirrel Monkeys.

C. W. Schindler, J. P. Gilman, J. Bergman, N. K. Mello, R. L. Woosley, and S. R. Goldberg (2002)
J. Pharmacol. Exp. Ther. 300, 180-187
 |  Abstract »  |  Full Text »  |  PDF »

Hyperactivity, elevated dopaminergic transmission, and response to amphetamine in M1 muscarinic acetylcholine receptor-deficient mice.

D. J. Gerber, T. D. Sotnikova, R. R. Gainetdinov, S. Y. Huang, M. G. Caron, and S. Tonegawa (2001)
PNAS 98, 15312-15317
 |  Abstract »  |  Full Text »  |  PDF »

The NH2-terminus of Norepinephrine Transporter Contains a Basolateral Localization Signal for Epithelial Cells.

H. H. Gu, X. Wu, B. Giros, M. G. Caron, M. J. Caplan, and G. Rudnick (2001)
Mol. Biol. Cell 12, 3797-3807
 |  Abstract »  |  Full Text »  |  PDF »

Differential Effects of D1- and D2-Like Compounds on Cocaine Self-Administration in Lewis and Fischer 344 Inbred Rats.

C. N. Haile and T. A. Kosten (2001)
J. Pharmacol. Exp. Ther. 299, 509-518
 |  Abstract »  |  Full Text »  |  PDF »

Cocaine-Induced Increases in Vesicular Dopamine Uptake: Role of Dopamine Receptors.

J. M. Brown, G. R. Hanson, and A. E. Fleckenstein (2001)
J. Pharmacol. Exp. Ther. 298, 1150-1153
 |  Abstract »  |  Full Text »  |  PDF »

The Dopamine Transporter and Cocaine Medication Development: Drug Self-Administration in Nonhuman Primates.

L. L. Howell and K. M. Wilcox (2001)
J. Pharmacol. Exp. Ther. 298, 1-6
 |  Abstract »  |  Full Text »

Cocaine Blocks HERG, but Not KvLQT1+minK, Potassium Channels.

S. Zhang, S. Rajamani, Y. Chen, Q. Gong, Y. Rong, Z. Zhou, A. Ruoho, and C. T. January (2001)
Mol. Pharmacol. 59, 1069-1076
 |  Abstract »  |  Full Text »

Progression of Changes in Dopamine Transporter Binding Site Density as a Result of Cocaine Self-Administration in Rhesus Monkeys.

S. R. Letchworth, M. A. Nader, H. R. Smith, D. P. Friedman, and L. J. Porrino (2001)
J. Neurosci. 21, 2799-2807
 |  Abstract »  |  Full Text »  |  PDF »

Intravenous Nicotine and Caffeine: Subjective and Physiological Effects in Cocaine Abusers.

B. E. Garrett and R. R. Griffiths (2001)
J. Pharmacol. Exp. Ther. 296, 486-494
 |  Abstract »  |  Full Text »

Regulation of Central Synaptic Transmission by 5-HT1B Auto- and Heteroreceptors.

H. Morikawa, O. J. Manzoni, J. C. Crabbe, and J. T. Williams (2001)
Mol. Pharmacol. 58, 1271-1278
 |  Abstract »  |  Full Text »

Electrophysiological Effects of Cocaethylene, Cocaine, and Ethanol on Dopaminergic Neurons of the Ventral Tegmental Area.

E. B. Bunney, S. B. Appel, and M. S. Brodie (2001)
J. Pharmacol. Exp. Ther. 297, 696-703
 |  Abstract »  |  Full Text »

Regulation of the Vesicular Monoamine Transporter-2: A Novel Mechanism for Cocaine and Other Psychostimulants.

J. M. Brown, G. R. Hanson, and A. E. Fleckenstein (2001)
J. Pharmacol. Exp. Ther. 296, 762-767
 |  Abstract »  |  Full Text »

The Antidepressant-Sensitive Dopamine Transporter in Drosophila melanogaster: A Primordial Carrier for Catecholamines.

P. Pörzgen, S. K. Park, J. Hirsh, M. S. Sonders, and S. G. Amara (2001)
Mol. Pharmacol. 59, 83-95
 |  Abstract »  |  Full Text »

Dopamine Release and Uptake Dynamics within Nonhuman Primate Striatum In Vitro.

S. J. Cragg, C. J. Hille, and S. A. Greenfield (2000)
J. Neurosci. 20, 8209-8217
 |  Abstract »  |  Full Text »  |  PDF »

Effect of Temperature on Dopamine Transporter Function and Intracellular Accumulation of Methamphetamine: Implications for Methamphetamine-Induced Dopaminergic Neurotoxicity.

T. Xie, U. D. McCann, S. Kim, J. Yuan, and G. A. Ricaurte (2000)
J. Neurosci. 20, 7838-7845
 |  Abstract »  |  Full Text »  |  PDF »

Comparison between Intraperitoneal and Oral Methylphenidate Administration: A Microdialysis and Locomotor Activity Study.

M. R. Gerasimov, M. Franceschi, N. D. Volkow, A. Gifford, S. J. Gatley, D. Marsteller, P. E. Molina, and S. L. Dewey (2000)
J. Pharmacol. Exp. Ther. 295, 51-57
 |  Abstract »  |  Full Text »

Acute and Chronic Dopamine Dynamics in a Nonhuman Primate Model of Recreational Cocaine Use.

C. W. Bradberry (2000)
J. Neurosci. 20, 7109-7115
 |  Abstract »  |  Full Text »  |  PDF »

Firing Rate of Nucleus Accumbens Neurons Is Dopamine-Dependent and Reflects the Timing of Cocaine-Seeking Behavior in Rats on a Progressive Ratio Schedule of Reinforcement.

S. M. Nicola and S. A. Deadwyler (2000)
J. Neurosci. 20, 5526-5537
 |  Abstract »  |  Full Text »  |  PDF »

Subtype-Selective Inhibition of Neuronal Nicotinic Acetylcholine Receptors by Cocaine Is Determined by the alpha 4 and beta 4 Subunits.

M. M. Francis, R. W. Vazquez, R. L. Papke, and R. E. Oswald (2000)
Mol. Pharmacol. 58, 109-119
 |  Abstract »  |  Full Text »

Vertical Shifts in Self-Administration Dose-Response Functions Predict a Drug-Vulnerable Phenotype Predisposed to Addiction.

P. V. Piazza, V. Deroche-Gamonent, F. Rouge-Pont, and M. Le Moal (2000)
J. Neurosci. 20, 4226-4232
 |  Abstract »  |  Full Text »  |  PDF »

Dopamine Transporter Transmembrane Domain Polar Mutants: Delta G and Delta Delta G Values Implicate Regions Important for Transporter Functions.

M. Itokawa, Z. Lin, N.-S. Cai, C. Wu, S. Kitayama, J.-B. Wang, and G. R. Uhl (2000)
Mol. Pharmacol. 57, 1093-1103
 |  Abstract »  |  Full Text »

Impact of Self-Administered Cocaine and Cocaine Cues on Extracellular Dopamine in Mesolimbic and Sensorimotor Striatum in Rhesus Monkeys.

C. W. Bradberry, R. L. Barrett-Larimore, P. Jatlow, and S. R. Rubino (2000)
J. Neurosci. 20, 3874-3883
 |  Abstract »  |  Full Text »  |  PDF »

Cocaine Potentiates Ethanol-Induced Excitation of Dopaminergic Reward Neurons in the Ventral Tegmental Area.

E. B. Bunney, S. B. Appel, and M. S. Brodie (2000)
J. Pharmacol. Exp. Ther. 293, 383-389
 |  Abstract »  |  Full Text »

Characterization of a Tropane Radioligand, [3H]2beta -Propanoyl-3beta -(4-tolyl) Tropane ([3H]PTT), for Dopamine Transport Sites in Rat Brain.

S. R. Letchworth, H. R. Smith, L. J. Porrino, B. A. Bennett, H. M. L. Davies, T. Sexton, and S. R. Childers (2000)
J. Pharmacol. Exp. Ther. 293, 686-696
 |  Abstract »  |  Full Text »

Dopamine transporter proline mutations influence dopamine uptake, cocaine analog recognition, and expression.

Z. LIN, M. ITOKAWA, and G. R. UHL (2000)
FASEB J 14, 715-728
 |  Abstract »  |  Full Text »

Amphetamine Withdrawal Alters Bistable States and Cellular Coupling in Rat Prefrontal Cortex and Nucleus Accumbens Neurons Recorded In Vivo.

S.-P. Onn and A. A. Grace (2000)
J. Neurosci. 20, 2332-2345
 |  Abstract »  |  Full Text »  |  PDF »

Role of High-Affinity Receptors and Membrane Transporters in Nonsynaptic Communication and Drug Action in the Central Nervous System.

E. S. Vizi (2000)
Pharmacol. Rev. 52, 63-90
 |  Abstract »  |  Full Text »  |  PDF »

Comparative Behavioral Pharmacology of Cocaine and the Selective Dopamine Uptake Inhibitor RTI-113 in the Squirrel Monkey.

L. L. Howell, P. W. Czoty, M. J. Kuhar, and F. I. Carrol (2000)
J. Pharmacol. Exp. Ther. 292, 521-529
 |  Abstract »  |  Full Text »

Transport-dependent Accessibility of a Cytoplasmic Loop Cysteine in the Human Dopamine Transporter.

N. Chen, J. V. Ferrer, J. A. Javitch, and J. B. Justice Jr. (2000)
J. Biol. Chem. 275, 1608-1614
 |  Abstract »  |  Full Text »  |  PDF »

Defining Proximity Relationships in the Tertiary Structure of the Dopamine Transporter. IDENTIFICATION OF A CONSERVED GLUTAMIC ACID AS A THIRD COORDINATE IN THE ENDOGENOUS Zn2+-BINDING SITE.

C. J. Loland, L. Norregaard, and U. Gether (1999)
J. Biol. Chem. 274, 36928-36934
 |  Abstract »  |  Full Text »  |  PDF »

Regulated Trafficking of the Human Dopamine Transporter. CLATHRIN-MEDIATED INTERNALIZATION AND LYSOSOMAL DEGRADATION IN RESPONSE TO PHORBOL ESTERS.

G. M. Daniels and S. G. Amara (1999)
J. Biol. Chem. 274, 35794-35801
 |  Abstract »  |  Full Text »  |  PDF »

Selective Potentiation of L-Type Calcium Channel Currents by Cocaine in Cardiac Myocytes.

L. S. Premkumar (1999)
Mol. Pharmacol. 56, 1138-1142
 |  Abstract »  |  Full Text »

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