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Science 4 September 1987:
Vol. 237. no. 4819, pp. 1219 - 1223
DOI: 10.1126/science.2820058
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Articles

Science, Vol 237, Issue 4819, 1219-1223
Copyright © 1987 by American Association for the Advancement of Science

articles

Cocaine receptors on dopamine transporters are related to self-administration of cocaine

MC Ritz, RJ Lamb, Goldberg SR, and MJ Kuhar

Although cocaine binds to several sites in the brain, the biochemical receptor mechanism or mechanisms associated with its dependence producing properties are unknown. It is shown here that the potencies of cocaine-like drugs in self-administration studies correlate with their potencies in inhibiting [3H]mazindol binding to the dopamine transporters in the rat striatum, but not with their potencies in binding to a large number of other presynaptic and postsynaptic binding sites. Thus, the cocaine receptor related to substance abuse is proposed to be the one associated with dopamine uptake inhibition.


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J. Pharmacol. Exp. Ther. 307, 356-366
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L. L. Peoples and D. Cavanaugh (2003)
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J. Biol. Chem. 278, 20162-20170
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sigma 1 Receptor-Related Neuroactive Steroids Modulate Cocaine-Induced Reward.
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J. Neurosci. 23, 3572-3576
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Cocaine Abusers Have an Overexpression of alpha -Synuclein in Dopamine Neurons.
D. C. Mash, Q. Ouyang, J. Pablo, M. Basile, S. Izenwasser, A. Lieberman, and R. J. Perrin (2003)
J. Neurosci. 23, 2564-2571
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Mixed Cocaine Agonist/Antagonist Properties of (+)-Methyl 4beta -(4-Chlorophenyl)-1-methylpiperidine-3alpha -carboxylate, a Piperidine-Based Analog of Cocaine.
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Cocaine Affinity Decreased by Mutations of Aromatic Residue Phenylalanine 105 in the Transmembrane Domain 2 of Dopamine Transporter.
X. Wu and H. H. Gu (2003)
Mol. Pharmacol. 63, 653-658
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Substance P Depresses Excitatory Synaptic Transmission in the Nucleus Accumbens Through Dopaminergic and Purinergic Mechanisms.
S. B. Kombian, K. V. V. Ananthalakshmi, S. S. Parvathy, and W. C. Matowe (2003)
J Neurophysiol 89, 728-737
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Withdrawal from Repeated Cocaine Alters Dopamine Transporter Protein Turnover in the Rat Striatum.
H. L. Kimmel, F. I. Carroll, and M. J. Kuhar (2003)
J. Pharmacol. Exp. Ther. 304, 15-21
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Chronic Cocaine Self-Administration Upregulates the Norepinephrine Transporter and Alters Functional Activity in the Bed Nucleus of the Stria Terminalis of the Rhesus Monkey.
D. J. Macey, H. R. Smith, M. A. Nader, and L. J. Porrino (2003)
J. Neurosci. 23, 12-16
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The Reinforcing Efficacy of the Dopamine Reuptake Inhibitor 2beta -Propanoyl-3beta -(4-tolyl)-tropane (PTT) as Measured by a Progressive-Ratio Schedule and a Choice Procedure in Rhesus Monkeys.
J. A. Lile, D. Morgan, A. M. Birmingham, Z. Wang, W. L. Woolverton, H. M. L. Davies, and M. A. Nader (2002)
J. Pharmacol. Exp. Ther. 303, 640-648
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Reinforcing Strength of a Novel Dopamine Transporter Ligand: Pharmacodynamic and Pharmacokinetic Mechanisms.
W. L. Woolverton, R. Ranaldi, Z. Wang, G. A. Ordway, I. A. Paul, P. Petukhov, and A. Kozikowski (2002)
J. Pharmacol. Exp. Ther. 303, 211-217
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Drug Addiction and Its Underlying Neurobiological Basis: Neuroimaging Evidence for the Involvement of the Frontal Cortex.
R. Z. Goldstein and N. D. Volkow (2002)
Am J Psychiatry 159, 1642-1652
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Methylphenidate Redistributes Vesicular Monoamine Transporter-2: Role of Dopamine Receptors.
V. Sandoval, E. L. Riddle, G. R. Hanson, and A. E. Fleckenstein (2002)
J. Neurosci. 22, 8705-8710
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Acute Cocaine Differentially Alters Accumbens and Striatal Dopamine Clearance in Low and High Cocaine Locomotor Responders: Behavioral and Electrochemical Recordings in Freely Moving Rats.
J. Sabeti, G. A. Gerhardt, and N. R. Zahniser (2002)
J. Pharmacol. Exp. Ther. 302, 1201-1211
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Neurobehavioral Assessments of Rats Perinatally Exposed to a Commercial Mixture of Polychlorinated Biphenyls.
P. J. Bushnell, V. C. Moser, R. C. MacPhail, W. M. Oshiro, E. C. Derr-Yellin, P. M. Phillips, and P. R. S. Kodavanti (2002)
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Effects of Cocaine Administration on VTA Cell Activity in Response to Prefrontal Cortex Stimulation.
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Biochemical and Behavioral Characterization of Novel Methylphenidate Analogs.
M. M. Schweri, H. M. Deutsch, A.T. Massey, and S. G. Holtzman (2002)
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Role of Dopamine D2-like Receptors in Cocaine Self-Administration: Studies with D2 Receptor Mutant Mice and Novel D2 Receptor Antagonists.
S. B. Caine, S. S. Negus, N. K. Mello, S. Patel, L. Bristow, J. Kulagowski, D. Vallone, A. Saiardi, and E. Borrelli (2002)
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Covalent modification of proteins by cocaine.
S.-X. Deng, N. Bharat, M. C. Fischman, and D. W. Landry (2002)
PNAS 99, 3412-3416
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C. E. Lau and L. Sun (2002)
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Serotonergic Attenuation of the Reinforcing and Neurochemical Effects of Cocaine in Squirrel Monkeys.
P. W. Czoty, B. C. Ginsburg, and L. L. Howell (2002)
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Interactions between Cocaine and Dopamine Agonists on Cardiovascular Function in Squirrel Monkeys.
C. W. Schindler, J. P. Gilman, J. Bergman, N. K. Mello, R. L. Woosley, and S. R. Goldberg (2002)
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Hyperactivity, elevated dopaminergic transmission, and response to amphetamine in M1 muscarinic acetylcholine receptor-deficient mice.
D. J. Gerber, T. D. Sotnikova, R. R. Gainetdinov, S. Y. Huang, M. G. Caron, and S. Tonegawa (2001)
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H. H. Gu, X. Wu, B. Giros, M. G. Caron, M. J. Caplan, and G. Rudnick (2001)
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Cocaine-Induced Increases in Vesicular Dopamine Uptake: Role of Dopamine Receptors.
J. M. Brown, G. R. Hanson, and A. E. Fleckenstein (2001)
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The Dopamine Transporter and Cocaine Medication Development: Drug Self-Administration in Nonhuman Primates.
L. L. Howell and K. M. Wilcox (2001)
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S. Zhang, S. Rajamani, Y. Chen, Q. Gong, Y. Rong, Z. Zhou, A. Ruoho, and C. T. January (2001)
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Effect of Temperature on Dopamine Transporter Function and Intracellular Accumulation of Methamphetamine: Implications for Methamphetamine-Induced Dopaminergic Neurotoxicity.
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Mol. Pharmacol. 58, 109-119
   Abstract »    Full Text »
Vertical Shifts in Self-Administration Dose-Response Functions Predict a Drug-Vulnerable Phenotype Predisposed to Addiction.
P. V. Piazza, V. Deroche-Gamonent, F. Rouge-Pont, and M. Le Moal (2000)
J. Neurosci. 20, 4226-4232
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Dopamine Transporter Transmembrane Domain Polar Mutants: Delta G and Delta Delta G Values Implicate Regions Important for Transporter Functions.
M. Itokawa, Z. Lin, N.-S. Cai, C. Wu, S. Kitayama, J.-B. Wang, and G. R. Uhl (2000)
Mol. Pharmacol. 57, 1093-1103
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Impact of Self-Administered Cocaine and Cocaine Cues on Extracellular Dopamine in Mesolimbic and Sensorimotor Striatum in Rhesus Monkeys.
C. W. Bradberry, R. L. Barrett-Larimore, P. Jatlow, and S. R. Rubino (2000)
J. Neurosci. 20, 3874-3883
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Cocaine Potentiates Ethanol-Induced Excitation of Dopaminergic Reward Neurons in the Ventral Tegmental Area.
E. B. Bunney, S. B. Appel, and M. S. Brodie (2000)
J. Pharmacol. Exp. Ther. 293, 383-389
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Characterization of a Tropane Radioligand, [3H]2beta -Propanoyl-3beta -(4-tolyl) Tropane ([3H]PTT), for Dopamine Transport Sites in Rat Brain.
S. R. Letchworth, H. R. Smith, L. J. Porrino, B. A. Bennett, H. M. L. Davies, T. Sexton, and S. R. Childers (2000)
J. Pharmacol. Exp. Ther. 293, 686-696
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Dopamine transporter proline mutations influence dopamine uptake, cocaine analog recognition, and expression.
Z. LIN, M. ITOKAWA, and G. R. UHL (2000)
FASEB J 14, 715-728
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