Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Science 28 August 1987:
Vol. 237. no. 4818, pp. 1051 - 1055
DOI: 10.1126/science.3112943
Prev | Table of Contents | Next

Articles

Science, Vol 237, Issue 4818, 1051-1055
Copyright © 1987 by American Association for the Advancement of Science

articles

Molecular diversity of the human T-gamma constant region genes

PG Pelicci, M Subar, A Weiss, R Dalla-Favera, and DR Littman

The human T cell antigen-receptor gamma chain, which is expressed on the surface of a subpopulation of CD3+ T lymphocytes, exhibits size polymorphism and varies in its ability to form disulfide bonds with a second polypeptide. Analysis of both genomic and complementary DNA clones encoding the human gamma polypeptide shows differences in lengths of the coding portions of the two constant region genes, C gamma 1 and C gamma 2. A single second-exon segment is always present in the C gamma 1 gene. C gamma 2 alleles containing either duplicated or triplicated second-exon segments are present in the normal human population and are expressed as messenger RNAs. Furthermore, a cysteine residue, encoded by the second exon of C gamma 1 and probably involved in interchain disulfide bridging, is absent in all C gamma 2 second-exon segments. These differences between C gamma 1 and the two alleles of C gamma 2 may explain the variability in molecular weight and disulfide bonding of gamma molecules expressed in different cells.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
The Four TCR Genes of Teleost Fish: The cDNA and Genomic DNA Analysis of Japanese Flounder (Paralichthys olivaceus) TCR {alpha}-, {beta}-, {gamma}-, and {delta}-Chains.
B.-H. Nam, I. Hirono, and T. Aoki (2003)
J. Immunol. 170, 3081-3090
   Abstract »    Full Text »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)