Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Site Tools

  • AAAS
  • Subscribe
  • Feedback

Site Search

Search Advanced

Science 28 August 1987:
Vol. 237. no. 4818, pp. 1047 - 1051
DOI: 10.1126/science.3039662
Prev | Table of Contents | Next

Articles

Science, Vol 237, Issue 4818, 1047-1051
Copyright © 1987 by American Association for the Advancement of Science

articles

Functional interaction and partial homology between human immunodeficiency virus and neuroleukin

MR Lee, DD Ho, and ME Gurney

Dementia is common in patients with AIDS, but the mechanism by which the human immunodeficiency virus type 1 (HIV-1) causes the neurological impairment is unknown. In this study the possibility that an antigen of HIV-1 suppresses neuronal responses to neurotrophic factors was examined. Both HIV-1 and a related retrovirus, simian immunodeficiency virus (SIV), inhibited the growth of sensory neurons from chick dorsal root ganglia in medium containing neuroleukin (NLK) but not in medium containing nerve growth factor. An unrelated type D retrovirus, simian acquired immunodeficiency syndrome virus, did not affect the growth of neurons in the presence of either neurotrophic factor. The inhibition by HIV-1 of neuron growth in the presence of NLK was found to be due to the gp120 envelope glycoprotein. Regions of sequence homology between gp120 and NLK may account for this inhibitory property of gp120 and functional interactions between gp120 and NLK may be important in the pathogenesis of the AIDS dementia complex.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Post-streptococcal opsoclonus-myoclonus syndrome associated with anti-neuroleukin antibodies.
P M Candler, R C Dale, S Griffin, A J Church, R Wait, M D Chapman, G Keir, G Giovannoni, and J H Rees (2006)
J. Neurol. Neurosurg. Psychiatry 77, 507-512
   Abstract »    Full Text »    PDF »
Candidate AIDS Vaccines.
B. S. Graham and P. F. Wright (1995)
N. Engl. J. Med. 333, 1331-1339
   Full Text »    PDF »
Growth Factors for Neuronal Survival and Process Regeneration: Implications in the Mammalian Central Nervous System.
S. A. Lipton (1989)
Arch Neurol 46, 1241-1248
   Abstract »    PDF »
The Acquired Immunodeficiency Syndrome (AIDS) Dementia Complex.
D. D. Ho, D. E. Bredesen, H. V. Vinters, and E. S. Daar (1989)
Ann Intern Med 111, 400-410
   Abstract »    PDF »
Second conserved domain of gp120 is important for HIV infectivity and antibody neutralization.
D. Ho, J. Kaplan, I. Rackauskas, and M. Gurney (1988)
Science 239, 1021-1023
   Abstract »    PDF »
The brain in AIDS: central nervous system HIV-1 infection and AIDS dementia complex.
R. Price, B Brew, J Sidtis, M Rosenblum, A. Scheck, and P Cleary (1988)
Science 239, 586-592
   Abstract »    PDF »
The human immunodeficiency virus: infectivity and mechanisms of pathogenesis.
A. Fauci (1988)
Science 239, 617-622
   Abstract »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)