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Science 28 August 1987:
Vol. 237. no. 4818, pp. 1036 - 1039
DOI: 10.1126/science.3616624
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Articles
Science, Vol 237, Issue 4818, 1036-1039
Copyright © 1987 by American Association for the Advancement of Science
Oncogenes in radioresistant, noncancerous skin fibroblasts from a cancer-prone family
EH Chang,
KF Pirollo,
ZQ Zou,
HY Cheung,
EL Lawler,
R Garner,
E White,
WB Bernstein,
JW Fraumeni Jr,
and
WA Blattner
Li-Fraumeni syndrome is manifested in a variety of neoplasms that are transmitted in a dominantly inherited pattern. The noncancerous skin fibroblasts of family members exhibit a unique characteristic of being resistant to the killing effect of ionizing radiation. A three- to eightfold elevation in expression of c-myc and an apparent activation of c-raf-1 gene have been observed in these noncancerous skin fibroblasts. These results may provide insight into the heritable defect underlying the familial predisposition to a variety of cancers.
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