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Science 28 August 1987:
Vol. 237. no. 4818, pp. 1036 - 1039
DOI: 10.1126/science.3616624
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Articles

Science, Vol 237, Issue 4818, 1036-1039
Copyright © 1987 by American Association for the Advancement of Science

articles

Oncogenes in radioresistant, noncancerous skin fibroblasts from a cancer-prone family

EH Chang, KF Pirollo, ZQ Zou, HY Cheung, EL Lawler, R Garner, E White, WB Bernstein, JW Fraumeni Jr, and WA Blattner

Li-Fraumeni syndrome is manifested in a variety of neoplasms that are transmitted in a dominantly inherited pattern. The noncancerous skin fibroblasts of family members exhibit a unique characteristic of being resistant to the killing effect of ionizing radiation. A three- to eightfold elevation in expression of c-myc and an apparent activation of c-raf-1 gene have been observed in these noncancerous skin fibroblasts. These results may provide insight into the heritable defect underlying the familial predisposition to a variety of cancers.


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DNA damage triggers a prolonged p53-dependent G1 arrest and long-term induction of Cip1 in normal human fibroblasts..
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Effect of antisense c-raf-1 on tumorigenicity and radiation sensitivity of a human squamous carcinoma.
U Kasid, A Pfeifer, T Brennan, M Beckett, R. Weichselbaum, A Dritschilo, and G. Mark (1989)
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The raf oncogene is associated with a radiation-resistant human laryngeal cancer.
U Kasid, A Pfeifer, R. Weichselbaum, A Dritschilo, and G. Mark (1987)
Science 237, 1039-1041
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