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Science 28 August 1987:
Vol. 237. no. 4818, pp. 1032 - 1035
DOI: 10.1126/science.3616623
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Articles
Science, Vol 237, Issue 4818, 1032-1035
Copyright © 1987 by American Association for the Advancement of Science
Tolerance induced by thymic epithelial grafts in birds
H Ohki,
C Martin,
C Corbel,
M Coltey,
and
NM Le Douarin
Grafts of the anterior limb bud introduced at embryonic day 4 between histoincompatible chick embryos were subject to chronic, mild rejection beginning from several weeks to several months after birth. In contrast, quail wing buds similarly grafted into chickens started to be rejected at the first or second week after birth and finally autoamputated. Embryonic thymus epithelium from donor quail (before it had been colonized by hemopoietic cells) was grafted into chicks. A chimeric thymic epithelial stroma was generated in which the lymphocytes of the chick acquired the capacity to recognize the grafted limb as self either permanently or for a protracted period of time. In such thymic chimeras the grafted wings were not rejected.
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