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Science 28 August 1987:
Vol. 237. no. 4818, pp. 1029 - 1032
DOI: 10.1126/science.2956685
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Articles

Science, Vol 237, Issue 4818, 1029-1032
Copyright © 1987 by American Association for the Advancement of Science

articles

Organ-resident, nonlymphoid cells suppress proliferation of autoimmune T-helper lymphocytes

RR Caspi, FG Roberge, and RB Nussenblatt

Local presentation of autoantigen by organ-resident cells inappropriately expressing Ia determinants has been implicated in organ-specific autoimmunity. Experimental autoimmune uveoretinitis, induced in rats by immunization with retinal soluble antigen, is used as a model of organ-specific autoimmunity. In an in vitro system derived from this model, uveitogenic rat T-helper lymphocytes specific to the retinal soluble antigen, or control T-helper lymphocytes reactive to the purified protein derivative of tuberculin, were cocultured with Ia-expressing syngeneic retinal glial cells (Muller cells) in the presence of specific antigen. Antigen presentation was not apparent under ordinary culture conditions, and the Muller cells profoundly suppressed the proliferative response of primed T-helper lymphocytes to antigen presented on conventional antigen-presenting cells, as well as their subsequent interleukin-2 (IL-2)-dependent expansion. Suppression of proliferation was accompanied by inhibition of IL-2 production in response to antigen, as well as by reduction in high-affinity IL-2 receptor expression, and proceeded via a contact-dependent mechanism. These results suggest a role for locally acting suppression mechanisms in immune regulation and maintenance of tissue homeostasis.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Reactivation of Uveitogenic T Cells by Retinal Astrocytes Derived from Experimental Autoimmune Uveitis-Prone B10RIII Mice.
G. Jiang, Y. Ke, D. Sun, G. Han, H. J. Kaplan, and H. Shao (2008)
Invest. Ophthalmol. Vis. Sci. 49, 282-289
   Abstract »    Full Text »    PDF »
In Vitro Activation of CD8 Interphotoreceptor Retinoid-Binding Protein-Specific T Cells Requires not only Antigenic Stimulation but also Exogenous Growth Factors..
Y. Peng, H. Shao, Y. Ke, P. Zhang, J. Xiang, H. J. Kaplan, and D. Sun (2006)
J. Immunol. 176, 5006-5014
   Abstract »    Full Text »    PDF »
Constitutive and Cytokine-Induced GITR Ligand Expression on Human Retinal Pigment Epithelium and Photoreceptors.
B. J. Kim, Z. Li, R. N. Fariss, D. F. Shen, S. P. Mahesh, C. Egwuagu, C.-R. Yu, C. N. Nagineni, C.-C. Chan, and R. B. Nussenblatt (2004)
Invest. Ophthalmol. Vis. Sci. 45, 3170-3176
   Abstract »    Full Text »    PDF »
The Antigen-Presenting Activity of Fresh, Adult Parenchymal Microglia and Perivascular Cells from Retina.
D. S. Gregerson, T. N. Sam, and S. W. McPherson (2004)
J. Immunol. 172, 6587-6597
   Abstract »    Full Text »    PDF »
Participation of Pigment Epithelium of Iris and Ciliary Body in Ocular Immune Privilege. 1. Inhibition of T-Cell Activation In Vitro by Direct Cell-to-Cell Contact.
M. Yoshida, M. Takeuchi, and W. Streilein (2000)
Invest. Ophthalmol. Vis. Sci. 41, 811-821
   Abstract »    Full Text »
Immunopathology of uveitis.
C.-C. CHAN and Q. LI (1998)
Br. J. Ophthalmol. 82, 91-96
   Full Text »


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Science. ISSN 0036-8075 (print), 1095-9203 (online)