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Science 21 August 1987: Vol. 237. no. 4817, pp. 893 - 896 DOI: 10.1126/science.3616618
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Articles
Science, Vol 237, Issue 4817, 893-896
Copyright © 1987 by American Association for the Advancement of Science
A parathyroid hormone-related protein implicated in malignant hypercalcemia: cloning and expression
LJ Suva,
GA Winslow,
RE Wettenhall,
RG Hammonds,
JM Moseley,
H Diefenbach-Jagger,
CP Rodda,
BE Kemp,
H Rodriguez,
EY Chen,
and
al. et
Humoral hypercalcemia of malignancy is a common complication of lung and certain other cancers. The hypercalcemia results from the actions of tumor factors on bone and kidney. We report here the isolation of full-length complementary DNA clones of a putative hypercalcemia factor, and the expression from the cloned DNA of the active protein in mammalian cells. The clones encode a prepro peptide of 36 amino acids and a mature protein of 141 amino acids that has significant homology with parathyroid hormone in the amino-terminal region. This previously unrecognized hormone may be important in normal as well as abnormal calcium metabolism.
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- Parathyroid Hormone-related Peptide Is Produced by Cultured Cerebellar Granule Cells in Response to L-type Voltage-sensitive Ca2+ Channel Flux via a Ca2+/Calmodulin-dependent Kinase Pathway.
- E. H. Holt, A. E. Broadus, and M. L. Brines (1996)
J. Biol. Chem.
271, 28105-28111
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- Evidence That Implicates the Parathyroid Hormone–Related Peptide in Vascular Stenosis : Increased Gene Expression in the Intima of Injured Rat Carotid Arteries and Human Restenotic Coronary Lesions.
- S.-i. Ozeki, A. Ohtsuru, S. Seto, S. Takeshita, H. Yano, T. Nakayama, M. Ito, T. Yokota, M. Nobuyoshi, G. V. Segre, et al. (1996)
Arterioscler. Thromb. Vasc. Biol.
16, 565-575
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- Molecular Cloning and Expression of Megakaryocyte Potentiating Factor cDNA.
- T. Kojima, M. Oh-eda, K. Hattori, Y. Taniguchi, M. Tamura, N. Ochi, and N. Yamaguchi (1995)
J. Biol. Chem.
270, 21984-21990
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- Cardiotrophin-1.
- D. Pennica, K. J. Shaw, T. A. Swanson, M. W. Moore, D. L. Shelton, K. A. Zioncheck, A. Rosenthal, T. Taga, N. F. Paoni, and W. I. Wood (1995)
J. Biol. Chem.
270, 10915-10922
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- Parathyroid Hormone (PTH)-PTH-related Peptide Hybrid Peptides Reveal Functional Interactions between the 1-14 and 15-34 Domains of the Ligand.
- T. J. Gardella, M. D. Luck, A. K. Wilson, H. T. Keutmann, S. R. Nussbaum, J. T. Potts Jr., and H. M. Kronenberg (1995)
J. Biol. Chem.
270, 6584-6588
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- A G protein-linked receptor for parathyroid hormone and parathyroid hormone-related peptide.
- H Juppner, A. Abou-Samra, M Freeman, X. Kong, E Schipani, J Richards, L. Kolakowski Jr, J Hock, J. Potts Jr, H. Kronenberg, et al. (1991)
Science
254, 1024-1026
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- Structure and functional expression of a human interleukin-8 receptor.
- W. Holmes, J Lee, W. Kuang, G. Rice, and W. Wood (1991)
Science
253, 1278-1280
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- Increased Serum Levels of a Parathyroid Hormone-like Protein in Malignancy-Associated Hypercalcemia.
- A. A. Budayr, R. A. Nissenson, R. F. Klein, K.K. Pun, O. H. Clark, D. Diep, C. D. Arnaud, and G. J. Strewler (1989)
Ann Intern Med
111, 807-812
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- Parathyroid Hormone-Related Protein in Adult T-Cell Leukemia-Lymphoma.
- T. Motokura, S. Fukumoto, T. Matsumoto, S. Takahashi, A. Fujita, T. Yamashita, T. Igarashi, and E. Ogata (1989)
Ann Intern Med
111, 484-488
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- Tumors of the Parathyroid Gland and Circulating Parathyroid Hormone-Related Protein Associated with Persistent Hypercalcemia.
- T. J. Rosol and C. C. Capen (1989)
Toxicol Pathol
17, 346-356
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- Review article : Hypercalcaemia of malignancy.
- D. Heath (1989)
Palliative Medicine
3, 1-11
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- Expression of a calcium-mobilizing parathyroid hormone-like peptide in lactating mammary tissue.
- M. Thiede and G. Rodan (1988)
Science
242, 278-280
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- Gallium Nitrate for Acute Treatment of Cancer-Related Hypercalcemia: A Randomized, Double-Blind Comparison to Calcitonin.
- R. P. WARRELL Jr., R. ISRAEL, M. FRISONE, T. SNYDER, J. J. GAYNOR, and R. S. BOCKMAN (1988)
Ann Intern Med
108, 669-674
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- Humoral Hypercalcemia of Malignancy.
- W. J. BURTIS, T. L. WU, K. L. INSOGNA, and A. F. STEWART (1988)
Ann Intern Med
108, 454-457
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- Similarity of synthetic peptide from human tumor to parathyroid hormone in vivo and in vitro.
- N Horiuchi, M. Caulfield, J. Fisher, M. Goldman, R. McKee, J. Reagan, J. Levy, R. Nutt, S. Rodan, T. Schofield, et al. (1987)
Science
238, 1566-1568
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- Parathyroid hormone-related protein of malignancy: active synthetic fragments.
- B. Kemp, J. Moseley, C. Rodda, P. Ebeling, R. Wettenhall, D Stapleton, H Diefenbach-Jagger, F Ure, V. Michelangeli, H. Simmons, et al. (1987)
Science
238, 1568-1570
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- The chondrogenic transcription factor Sox9 is a target of signaling by the parathyroid hormone-related peptide in the growth plate of endochondral bones.
- W. Huang, U.-i. Chung, H. M. Kronenberg, and B. de Crombrugghe (2001)
PNAS
98, 160-165
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