Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Science 21 August 1987:
Vol. 237. no. 4817, pp. 885 - 888
DOI: 10.1126/science.3303333
Prev | Table of Contents | Next

Articles

Science, Vol 237, Issue 4817, 885-888
Copyright © 1987 by American Association for the Advancement of Science

articles

Fish oil prevents insulin resistance induced by high-fat feeding in rats

LH Storlien, EW Kraegen, DJ Chisholm, GL Ford, DG Bruce, and WS Pascoe

Non-insulin-dependent diabetes mellitus is an increasingly prevalent disease in Western and developing societies. A major metabolic abnormality of non-insulin-dependent diabetes is impaired insulin action (insulin resistance). Diets high in fat from vegetable and nonaquatic animal sources (rich in linoleic acid, an omega-6 fatty acid, and saturated fats) lead to insulin resistance. In rats fed high-fat diets, replacement of only 6 percent of the linoleic omega-6 fatty acids from safflower oil with long-chain polyunsaturated omega-3 fatty acids from fish oil prevented the development of insulin resistance. The effect was most pronounced in the liver and skeletal muscle, which have important roles in glucose supply and demand. The results may be important for therapy or prevention of non-insulin-dependent diabetes mellitus.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Response to Comment on: Reyna et al. (2008) Elevated Toll-Like Receptor 4 Expression and Signaling in Muscle From Insulin-Resistant Subjects. Diabetes 57:2595-2602.
S. M. Reyna, S. Ghosh, R. A. DeFronzo, C. P. Jenkinson, and N. Musi (2009)
Diabetes 58, e6-e7
   Full Text »    PDF »
Fatty Acid Incubation of Myotubes From Humans With Type 2 Diabetes Leads to Enhanced Release of {beta}-Oxidation Products Because of Impaired Fatty Acid Oxidation: Effects of Tetradecylthioacetic Acid and Eicosapentaenoic Acid.
A. J. Wensaas, A. C. Rustan, M. Just, R. K. Berge, C. A. Drevon, and M. Gaster (2009)
Diabetes 58, 527-535
   Abstract »    Full Text »    PDF »
Long-Chain (n-3) Polyunsaturated Fatty Acids Prevent Metabolic and Vascular Disorders in Fructose-Fed Rats.
V. Robbez Masson, A. Lucas, A.-M. Gueugneau, J.-P. Macaire, J.-L. Paul, A. Grynberg, and D. Rousseau (2008)
J. Nutr. 138, 1915-1922
   Abstract »    Full Text »    PDF »
Treatment for 2 mo with n 3 polyunsaturated fatty acids reduces adiposity and some atherogenic factors but does not improve insulin sensitivity in women with type 2 diabetes: a randomized controlled study.
M. Kabir, G. Skurnik, N. Naour, V. Pechtner, E. Meugnier, S. Rome, A. Quignard-Boulange, H. Vidal, G. Slama, K. Clement, et al. (2007)
Am. J. Clinical Nutrition 86, 1670-1679
   Abstract »    Full Text »    PDF »
Globular adiponectin resistance develops independently of impaired insulin-stimulated glucose transport in soleus muscle from high-fat-fed rats.
K. L. Mullen, A. C. Smith, K. A. Junkin, and D. J. Dyck (2007)
Am J Physiol Endocrinol Metab 293, E83-E90
   Abstract »    Full Text »    PDF »
n-3 Fatty Acids in the Treatment of Diabetic Patients: Biological rationale and clinical data.
R. De Caterina, R. Madonna, A. Bertolotto, and E. B. Schmidt (2007)
Diabetes Care 30, 1012-1026
   Full Text »    PDF »
n-3 Fatty Acids Preserve Insulin Sensitivity In Vivo in a Peroxisome Proliferator-Activated Receptor-{alpha}-Dependent Manner.
S. Neschen, K. Morino, J. Dong, Y. Wang-Fischer, G. W. Cline, A. J. Romanelli, J. C. Rossbacher, I. K. Moore, W. Regittnig, D. S. Munoz, et al. (2007)
Diabetes 56, 1034-1041
   Abstract »    Full Text »    PDF »
PPAR{alpha} activation reverses adverse effects induced by high-saturated-fat feeding on pancreatic beta-cell function in late pregnancy.
M. J. Holness, N. D. Smith, G. K. Greenwood, and M. C. Sugden (2007)
Am J Physiol Endocrinol Metab 292, E1087-E1094
   Abstract »    Full Text »    PDF »
Skeletal muscle lipid deposition and insulin resistance: effect of dietary fatty acids and exercise.
M. P Corcoran, S. Lamon-Fava, and R. A Fielding (2007)
Am. J. Clinical Nutrition 85, 662-677
   Abstract »    Full Text »    PDF »
Long-chain omega-3 fatty acids regulate bovine whole-body protein metabolism by promoting muscle insulin signalling to the Akt-mTOR-S6K1 pathway and insulin sensitivity.
A.-A. Gingras, P. J. White, P. Y. Chouinard, P. Julien, T. A. Davis, L. Dombrowski, Y. Couture, P. Dubreuil, A. Myre, K. Bergeron, et al. (2007)
J. Physiol. 579, 269-284
   Abstract »    Full Text »    PDF »
Fish Oil Regulates Adiponectin Secretion by a Peroxisome Proliferator-Activated Receptor-{gamma}-Dependent Mechanism in Mice..
S. Neschen, K. Morino, J. C. Rossbacher, R. L. Pongratz, G. W. Cline, S. Sono, M. Gillum, and G. I. Shulman (2006)
Diabetes 55, 924-928
   Abstract »    Full Text »    PDF »
Eicosapentaenoic acid (20:5 n-3) increases fatty acid and glucose uptake in cultured human skeletal muscle cells.
V. Aas, M. H. Rokling-Andersen, E. T. Kase, G. H. Thoresen, and A. C. Rustan (2006)
J. Lipid Res. 47, 366-374
   Abstract »    Full Text »    PDF »
Intake of Fish and n3 Fatty Acids and Risk of Coronary Heart Disease Among Japanese: The Japan Public Health Center-Based (JPHC) Study Cohort I.
H. Iso, M. Kobayashi, J. Ishihara, S. Sasaki, K. Okada, Y. Kita, Y. Kokubo, S. Tsugane, and for the JPHC Study Group (2006)
Circulation 113, 195-202
   Abstract »    Full Text »    PDF »
Adipose tissue compensates for defect of phosphatidylinositol 3'-kinase induced in liver and muscle by dietary fish oil in fed rats.
C. Corporeau, C. L. Foll, M. Taouis, J.-P. Gouygou, J.-P. Berge, and J. Delarue (2006)
Am J Physiol Endocrinol Metab 290, E78-E86
   Abstract »    Full Text »    PDF »
Dietary (n-3) Long Chain Polyunsaturated Fatty Acids Prevent Sucrose-Induced Insulin Resistance in Rats.
Ghafoorunissa, A. Ibrahim, L. Rajkumar, and V. Acharya (2005)
J. Nutr. 135, 2634-2638
   Abstract »    Full Text »    PDF »
Eicosapentaenoic fatty acid increases leptin secretion from primary cultured rat adipocytes: role of glucose metabolism.
P. Perez-Matute, A. Marti, J. A. Martinez, M. P. Fernandez-Otero, K. L. Stanhope, P. J. Havel, and M. J. Moreno-Aliaga (2005)
Am J Physiol Regulatory Integrative Comp Physiol 288, R1682-R1688
   Abstract »    Full Text »    PDF »
Elevated n-3 fatty acids in a high-fat diet attenuate the increase in PDH kinase activity but not PDH activity in human skeletal muscle.
E. A. Turvey, G. J. F. Heigenhauser, M. Parolin, and S. J. Peters (2005)
J Appl Physiol 98, 350-355
   Abstract »    Full Text »    PDF »
Islet neogenesis: an apparent key component of long-term pancreas adaptation to increased insulin demand.
H Del Zotto, M I Borelli, L Flores, M E Garcia, C L Gomez Dumm, A Chicco, Y B Lombardo, and J J Gagliardino (2004)
J. Endocrinol. 183, 321-330
   Abstract »    Full Text »    PDF »
Increased n-6 polyunsaturated fatty acids do not attenuate the effects of long-chain n-3 polyunsaturated fatty acids on insulin sensitivity or triacylglycerol reduction in Indian Asians.
L. M Brady, S. S Lovegrove, S. V. Lesauvage, B. A Gower, A.-M. Minihane, C. M Williams, and J. A Lovegrove (2004)
Am. J. Clinical Nutrition 79, 983-991
   Abstract »    Full Text »    PDF »
Differential Metabolic Effects of Saturated Versus Polyunsaturated Fats in Ketogenic Diets.
B. S. Fuehrlein, M. S. Rutenberg, J. N. Silver, M. W. Warren, D. W. Theriaque, G. E. Duncan, P. W. Stacpoole, and M. L. Brantly (2004)
J. Clin. Endocrinol. Metab. 89, 1641-1645
   Abstract »    Full Text »    PDF »
Reduced Lipid Oxidation in Skeletal Muscle From Type 2 Diabetic Subjects May Be of Genetic Origin: Evidence From Cultured Myotubes.
M. Gaster, A. C. Rustan, V. Aas, and H. Beck-Nielsen (2004)
Diabetes 53, 542-548
   Abstract »    Full Text »    PDF »
Acute {omega}-3 Fatty Acid Enrichment Selectively Reverses High-Saturated Fat Feeding-Induced Insulin Hypersecretion But Does Not Improve Peripheral Insulin Resistance.
M. J. Holness, N. D. Smith, G. K. Greenwood, and M. C. Sugden (2004)
Diabetes 53, S166-171
   Abstract »    Full Text »
Fish Oil Affects Pancreatic Fat Storage, Pyruvate Dehydrogenase Complex Activity and Insulin Secretion in Rats Fed a Sucrose-Rich Diet.
D. Pighin, L. Karabatas, A. Rossi, A. Chicco, J. C. Basabe, and Y. B. Lombardo (2003)
J. Nutr. 133, 4095-4101
   Abstract »    Full Text »    PDF »
A Fish Oil Diet Does Not Reverse Insulin Resistance despite Decreased Adipose Tissue TNF-{alpha} Protein Concentration in ApoE-3*Leiden Mice.
M. Muurling, R. P. Mensink, H. Pijl, J. A. Romijn, L. M. Havekes, and P. J. Voshol (2003)
J. Nutr. 133, 3350-3355
   Abstract »    Full Text »    PDF »
Impaired Cathepsin L Gene Expression in Skeletal Muscle Is Associated With Type 2 Diabetes.
X. Huang, A. Vaag, E. Carlsson, M. Hansson, B. Ahren, and L. Groop (2003)
Diabetes 52, 2411-2418
   Abstract »    Full Text »    PDF »
Diabetogenic Impact of Long-Chain {omega}-3 Fatty Acids on Pancreatic {beta}-Cell Function and the Regulation of Endogenous Glucose Production.
M. J. Holness, G. K. Greenwood, N. D. Smith, and M. C. Sugden (2003)
Endocrinology 144, 3958-3968
   Abstract »    Full Text »    PDF »
Plasma fatty acid composition and incidence of diabetes in middle-aged adults: the Atherosclerosis Risk in Communities (ARIC) Study.
L. Wang, A. R Folsom, Z.-J. Zheng, J. S Pankow, and J. H Eckfeldt (2003)
Am. J. Clinical Nutrition 78, 91-98
   Abstract »    Full Text »    PDF »
Differential Effects of Fatty Acids and Exercise on Body Weight Regulation and Metabolism in Female Wistar Rats.
K-L. C. Jen, A. Buison, M. Pellizzon, F. Ordiz Jr., L. Santa Ana, and J. Brown (2003)
Experimental Biology and Medicine 228, 843-849
   Abstract »    Full Text »    PDF »
A High Fat Diet Inhibits {delta}-Aminolevulinate Dehydratase and Increases Lipid Peroxidation in Mice (Mus musculus).
V. Folmer, J. C. M. Soares, D. Gabriel, and J. B. T. Rocha (2003)
J. Nutr. 133, 2165-2170
   Abstract »    Full Text »    PDF »
Dietary Fish Oil Increases Lipid Mobilization but Does Not Decrease Lipid Storage-Related Enzyme Activities in Adipose Tissue of Insulin-Resistant, Sucrose-Fed Rats.
E. Peyron-Caso, A. Quignard-Boulange, M. Laromiguiere, S. Feing-Kwong-Chan, A. Veronese, B. Ardouin, G. Slama, and S. W. Rizkalla (2003)
J. Nutr. 133, 2239-2243
   Abstract »    Full Text »    PDF »
Palmitate-Induced Activation of the Hexosamine Pathway in Human Myotubes: Increased Expression of Glutamine:Fructose-6-Phosphate Aminotransferase.
C. Weigert, K. Klopfer, C. Kausch, K. Brodbeck, M. Stumvoll, H. U. Haring, and E. D. Schleicher (2003)
Diabetes 52, 650-656
   Abstract »    Full Text »    PDF »
Multiple Indexes of Lipid Availability Are Independently Related to Whole Body Insulin Action in Healthy Humans.
A. D. Kriketos, S. M. Furler, S. K. Gan, A. M. Poynten, D. J. Chisholm, and L. V. Campbell (2003)
J. Clin. Endocrinol. Metab. 88, 793-798
   Abstract »    Full Text »    PDF »
Dietary Cod Protein Restores Insulin-Induced Activation of Phosphatidylinositol 3-Kinase/Akt and GLUT4 Translocation to the T-Tubules in Skeletal Muscle of High-Fat-Fed Obese Rats.
F. Tremblay, C. Lavigne, H. Jacques, and A. Marette (2003)
Diabetes 52, 29-37
   Abstract »    Full Text »    PDF »
Dietary Polyunsaturated Fats Regulate Rat Liver Sterol Regulatory Element Binding Proteins-1 and -2 in Three Distinct Stages and by Different Mechanisms.
J. Xu, H. Cho, S. O'Malley, J. H. Y. Park, and S. D. Clarke (2002)
J. Nutr. 132, 3333-3339
   Abstract »    Full Text »    PDF »
Inhibition of glycogen synthesis by fatty acid in C2C12 muscle cells is independent of PKC-alpha , -epsilon , and -theta.
R. Cazzolli, D. L. Craig, T. J. Biden, and C. Schmitz-Peiffer (2002)
Am J Physiol Endocrinol Metab 282, E1204-E1213
   Abstract »    Full Text »    PDF »
Polyunsaturated Fatty Acyl Coenzyme A Suppress the Glucose-6-phosphatase Promoter Activity by Modulating the DNA Binding of Hepatocyte Nuclear Factor 4alpha.
F. Rajas, A. Gautier, I. Bady, S. Montano, and G. Mithieux (2002)
J. Biol. Chem. 277, 15736-15744
   Abstract »    Full Text »    PDF »
Tetradecylthioacetic acid prevents high fat diet induced adiposity and insulin resistance.
L. Madsen, M. Guerre-Millo, E. N. Flindt, K. Berge, K. J. Tronstad, E. Bergene, E. Sebokova, A. C. Rustan, J. Jensen, S. Mandrup, et al. (2002)
J. Lipid Res. 43, 742-750
   Abstract »    Full Text »    PDF »
Lipid Infusion Impairs Physiologic Insulin-Mediated Capillary Recruitment and Muscle Glucose Uptake In Vivo.
L. H. Clerk, S. Rattigan, and M. G. Clark (2002)
Diabetes 51, 1138-1145
   Abstract »    Full Text »    PDF »
Fatty Acid-Induced Insulin Resistance: Decreased Muscle PI3K Activation But Unchanged Akt Phosphorylation.
Y. T. Kruszynska, D. S. Worrall, J. Ofrecio, J. P. Frias, G. Macaraeg, and J. M. Olefsky (2002)
J. Clin. Endocrinol. Metab. 87, 226-234
   Abstract »    Full Text »    PDF »
Prevention of skeletal muscle insulin resistance by dietary cod protein in high fat-fed rats.
C. Lavigne, F. Tremblay, G. Asselin, H. Jacques, and A. Marette (2001)
Am J Physiol Endocrinol Metab 281, E62-E71
   Abstract »    Full Text »    PDF »
Are diets high in omega-6 polyunsaturated fatty acids unhealthy?.
E.M. Berry (2001)
Eur. Heart J. Suppl. 3, D37-D41
   Abstract »    PDF »
Reduced Hepatic Triglyceride Secretion in Rats Fed Docosahexaenoic Acid-Rich Fish Oil Suppresses Postprandial Hypertriglyceridemia.
I. Ikeda, J. Kumamaru, N. Nakatani, M. Sakono, I. Murota, and K. Imaizumi (2001)
J. Nutr. 131, 1159-1164
   Abstract »    Full Text »
DAG accumulation from saturated fatty acids desensitizes insulin stimulation of glucose uptake in muscle cells.
E. Montell, M. Turini, M. Marotta, M. Roberts, V. Noe, C. J. Ciudad, K. Mace, and A. M. Gomez-Foix (2001)
Am J Physiol Endocrinol Metab 280, E229-E237
   Abstract »    Full Text »    PDF »
Intake of Fish and Omega-3 Fatty Acids and Risk of Stroke in Women.
H. Iso, K. M. Rexrode, M. J. Stampfer, J. E. Manson, G. A. Colditz, F. E. Speizer, C. H. Hennekens, and W. C. Willett (2001)
JAMA 285, 304-312
   Abstract »    Full Text »    PDF »
Development of leptin resistance in rat soleus muscle in response to high-fat diets.
G. R. Steinberg and D. J. Dyck (2000)
Am J Physiol Endocrinol Metab 279, E1374-E1382
   Abstract »    Full Text »    PDF »
High-fat diet-induced muscle insulin resistance: relationship to visceral fat mass.
J.-Y. Kim, L. A. Nolte, P. A. Hansen, D.-H. Han, K. Ferguson, P. A. Thompson, and J. O. Holloszy (2000)
Am J Physiol Regulatory Integrative Comp Physiol 279, R2057-R2065
   Abstract »    Full Text »    PDF »
Effect of dietary fish oil on the sensitivity of hepatic lipid metabolism to regulation by insulin.
P. W. Baker and G. F. Gibbons (2000)
J. Lipid Res. 41, 719-726
   Abstract »    Full Text »
Short-term, high-fat diets lower circulating leptin concentrations in rats1.
D. A Ainslie, J. Proietto, B. C Fam, and A. W Thorburn (2000)
Am. J. Clinical Nutrition 71, 438-442
   Abstract »    Full Text »    PDF »
Peroxisome proliferator-activated receptors: a family of lipid-activated transcription factors.
S. D Clarke, P. Thuillier, R. A Baillie, and X. Sha (1999)
Am. J. Clinical Nutrition 70, 566-571
   Abstract »    Full Text »    PDF »
Ceramide Generation Is Sufficient to Account for the Inhibition of the Insulin-stimulated PKB Pathway in C2C12 Skeletal Muscle Cells Pretreated with Palmitate.
C. Schmitz-Peiffer, D. L. Craig, and T. J. Biden (1999)
J. Biol. Chem. 274, 24202-24210
   Abstract »    Full Text »    PDF »
Percent cholesterol absorption in normal women and men quantified with dual stable isotopic tracers and negative ion mass spectrometry.
M. S. Bosner, L. G. Lange, W. F. Stenson, and R. E. Ostlund , Jr. (1999)
J. Lipid Res. 40, 302-308
   Abstract »    Full Text »
A modified high-fat diet induces insulin resistance in rat skeletal muscle but not adipocytes.
J. J. Wilkes, A. Bonen, and R. C. Bell (1998)
Am J Physiol Endocrinol Metab 275, E679-E686
   Abstract »    Full Text »    PDF »
Role of Arachidonic Acid in the Regulation of the Inflammatory Response in TNF-{alpha}-treated Rats.
P.-R. Ling, P. Boyce, and B. R. Bistrian (1998)
JPEN J Parenter Enteral Nutr 22, 268-275
   Abstract »    PDF »
Nutritional Factors Adversely Influencing the Glucose/Insulin System.
M. Fields (1998)
J. Am. Coll. Nutr. 17, 317-321
   Abstract »    Full Text »    PDF »
Menhaden oil prevents but does not reverse sucrose-induced insulin resistance in rats.
D. A. Podolin, E. C. Gayles, Y. Wei, J. S. Thresher, and M. J. Pagliassotti (1998)
Am J Physiol Regulatory Integrative Comp Physiol 274, R840-R848
   Abstract »    Full Text »    PDF »
Dietary (n-3) and (n-6) Polyunsaturated Fatty Acids Rapidly Modify Fatty Acid Composition and Insulin Effects in Rat Adipocytes.
M. Fickova, P. Hubert, G. Crémel, and C. Leray (1998)
J. Nutr. 128, 512-519
   Abstract »    Full Text »
Fatty acids and eicosanoids regulate gene expression through direct interactions with peroxisome proliferator-activated receptors alpha  and gamma.
S. A. Kliewer, S. S. Sundseth, S. A. Jones, P. J. Brown, G. B. Wisely, C. S. Koble, P. Devchand, W. Wahli, T. M. Willson, J. M. Lenhard, et al. (1997)
PNAS 94, 4318-4323
   Abstract »    Full Text »    PDF »
Expression and Insulin-regulated Distribution of Caveolin in Skeletal Muscle.
P.ón Muñoz, S. Mora, L. Sevilla, P. Kaliman, E. Tomàs, A. Gumà, X. Testar, M. Palacín, and A. Zorzano (1996)
J. Biol. Chem. 271, 8133-8139
   Abstract »    Full Text »    PDF »
Effects of n-3 Polyunsaturated Fatty Acids on Glucose Homeostasis and Blood Pressure in Essential Hypertension: A Randomized, Controlled Trial.
I. Toft, K. H. Bonaa, O. C. Ingebretsen, A. Nordoy, and T. Jenssen (1995)
Ann Intern Med 123, 911-918
   Abstract »    Full Text »
Glucose Metabolism in Abdominally Obese Hypertensive and Normotensive Subjects.
I. M. O'Shaughnessy, T. J. Myers, K. Stepniakowski, P. Nazzaro, T. M. Kelly, R. G. Hoffmann, B. M. Egan, and A. H. Kissebah (1995)
Hypertension 26, 186-192
   Abstract »    Full Text »
The Deadly Quartet: Upper-Body Obesity, Glucose Intolerance, Hypertriglyceridemia, and Hypertension.
N. M. Kaplan (1989)
Arch Intern Med 149, 1514-1520
   Abstract »    PDF »
ANOTHER POTENTIAL BENEFIT OF FISH OIL?.
(1987)
Journal Watch (General) 1987, 6
   Full Text »
Elevated n-3 fatty acids in a high-fat diet attenuate the increase in PDH kinase activity but not PDH activity in human skeletal muscle.
E. A. Turvey, G. J. F. Heigenhauser, M. Parolin, and S. J. Peters (2005)
J Appl Physiol 98, 350-355
   Abstract »    Full Text »    PDF »
Polyunsaturated Fatty Acids Suppress Hepatic Sterol Regulatory Element-binding Protein-1 Expression by Accelerating Transcript Decay.
J. Xu, M. Teran-Garcia, J. H. Y. Park, M. T. Nakamura, and S. D. Clarke (2001)
J. Biol. Chem. 276, 9800-9807
   Abstract »    Full Text »    PDF »
Arachidonic Acid Stimulates Glucose Uptake in 3T3-L1 Adipocytes by Increasing GLUT1 and GLUT4 Levels at the Plasma Membrane. EVIDENCE FOR INVOLVEMENT OF LIPOXYGENASE METABOLITES AND PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR gamma.
C. Nugent, J. B. Prins, J. P. Whitehead, J. M. Wentworth, V. K. K. Chatterjee, and S. O'Rahilly (2001)
J. Biol. Chem. 276, 9149-9157
   Abstract »    Full Text »    PDF »
Dual Action of Eicosapentaenoic Acid in Hepatoma Cells. UP-REGULATION OF METABOLIC ACTION OF INSULIN AND INHIBITION OF CELL PROLIFERATION.
M. Murata, H. Kaji, K. Iida, Y. Okimura, and K. Chihara (2001)
J. Biol. Chem. 276, 31422-31428
   Abstract »    Full Text »    PDF »
N-3 Polyunsaturated fatty acids prevent the defect of insulin receptor signaling in muscle.
M. Taouis, C. Dagou, C. Ster, G. Durand, M. Pinault, and J. Delarue (2002)
Am J Physiol Endocrinol Metab 282, E664-E671
   Abstract »    Full Text »    PDF »
Contrasting effects of fish oil and safflower oil on hepatic peroxisomal and tissue lipid content.
S. Neschen, I. Moore, W. Regittnig, C. L. Yu, Y. Wang, M. Pypaert, K. F. Petersen, and G. I. Shulman (2002)
Am J Physiol Endocrinol Metab 282, E395-E401
   Abstract »    Full Text »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)