Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Site Tools

  • AAAS
  • Subscribe
  • Feedback

Site Search

Search Advanced

Science 14 August 1987:
Vol. 237. no. 4816, pp. 775 - 777
DOI: 10.1126/science.3616608
Prev | Table of Contents | Next

Articles

Science, Vol 237, Issue 4816, 775-777
Copyright © 1987 by American Association for the Advancement of Science

articles

A novel mode of arbovirus transmission involving a nonviremic host

LD Jones, CR Davies, GM Steele, and PA Nuttall

In nature, infected and uninfected arthropod vectors often feed together on an animal. In mimicking this scenario in the laboratory, uninfected vectors were found to acquire virus while cofeeding on the same host as infected vectors. However, the vertebrate host on which they fed did not develop detectable levels of virus in its blood. These observations were made with Thogoto virus, an influenza-like virus of medical and veterinary significance. Rhipicephalus appendiculatus ticks were used as the vector and guinea pigs as the vertebrate host. The results demonstrate that a vertebrate that is apparently refractory to infection by an arthropod-borne virus can still play an important role in the epidemiology of the virus, and they suggest a novel mode of arthropod-borne virus transmission.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
NONVIREMIC TRANSMISSION OF WEST NILE VIRUS: EVALUATION OF THE EFFECTS OF SPACE, TIME, AND MOSQUITO SPECIES.
C. E. McGEE, B. S. SCHNEIDER, Y. A. GIRARD, D. L. VANLANDINGHAM, and S. HIGGS (2007)
Am J Trop Med Hyg 76, 424-430
   Abstract »    Full Text »    PDF »
Biological Transmission of Arboviruses: Reexamination of and New Insights into Components, Mechanisms, and Unique Traits as Well as Their Evolutionary Trends.
G. Kuno and G.-J. J. Chang (2005)
Clin. Microbiol. Rev. 18, 608-637
   Abstract »    Full Text »    PDF »
Nonviremic transmission of West Nile virus.
S. Higgs, B. S. Schneider, D. L. Vanlandingham, K. A. Klingler, and E. A. Gould (2005)
PNAS 102, 8871-8874
   Abstract »    Full Text »    PDF »
Exploring the sialome of the tick Ixodes scapularis.
J. G. Valenzuela, I. M. B. Francischetti, V. M. Pham, M. K. Garfield, T. N. Mather, and J. M. C. Ribeiro (2002)
J. Exp. Biol. 205, 2843-2864
   Abstract »    Full Text »    PDF »
Transmission of Vesicular Stomatitis Virus from Infected to Noninfected Black Flies Co-Feeding on Nonviremic Deer Mice.
D. G. Mead, F. B. Ramberg, D. G. Besselsen, and C. J. Maré (2000)
Science 287, 485-487
   Abstract »    Full Text »
Mx1-Based Resistance to Thogoto Virus in A2G Mice Is Bypassed in Tick-Mediated Virus Delivery.
J. T. Dessens and P. A. Nuttall (1998)
J. Virol. 72, 8362-8364
   Abstract »    Full Text »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)