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Science 14 August 1987:
Vol. 237. no. 4816, pp. 758 - 762
DOI: 10.1126/science.3039657
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Articles

Science, Vol 237, Issue 4816, 758-762
Copyright © 1987 by American Association for the Advancement of Science

articles

Cell-autonomous determination of cell-type choice in Dictyostelium development by cell-cycle phase

RH Gomer and RA Firtel

The developmental fate of individual cells has been examined in a system that allows Dictyostelium discoideum cells to differentiate in the absence of aggregation. The results show that the propensity of single amoebae to differentiate into either prespore or prestalk cells occurs by a cell-autonomous mechanism dependent on the cell's position in the cell cycle at the initiation of development. Cells that divide between approximately 1 1/2 hours before and approximately 40 minutes after the differentiation-inducing starvation become prestalk, whereas cells dividing at other times become prespore cells. These results suggest mechanisms by which an initial proportioning of the two cell types within the aggregate is achieved.


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TagA, a putative serine protease/ABC transporter of Dictyostelium that is required for cell fate determination at the onset of development.
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The different components of a multisubunit cell number-counting factor have both unique and overlapping functions.
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YakA, a protein kinase required for the transition from growth to development in Dictyostelium.
G. Souza, S Lu, and A Kuspa (1998)
Development 125, 2291-2302
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Desynchronization of cells on the developmental path triggers the formation of spiral waves of cAMP during Dictyostelium aggregation.
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Autonomous and nonautonomous regulation of axis formation by antagonistic signaling via 7-span cAMP receptors and GSK3 in Dictyostelium.
G. T. Ginsburg and A. R. Kimmel (1997)
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RtoA links initial cell type choice to the cell cycle in Dictyostelium.
S. Wood, R. Ammann, D. Brock, L Li, T Spann, and R. Gomer (1996)
Development 122, 3677-3685
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Presence and expression of G2 cyclins in the coelenterate hydra.
I Scheurlen, S. Hoffmeister, and H. Schaller (1996)
J. Cell Sci. 109, 1063-1069
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pH Regulation of the F-actin Binding Properties of Dictyostelium Elongation Factor 1[IMAGE].
B. T. Edmonds, J. Murray, and J. Condeelis (1995)
J. Biol. Chem. 270, 15222-15230
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Integration of signaling information in controlling cell-fate decisions in Dictyostelium..
R A Firtel (1995)
Genes & Dev. 9, 1427-1444
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Overexpression of a truncated cyclin B gene arrests Dictyostelium cell division during mitosis.
Q Luo, C Michaelis, and G Weeks (1994)
J. Cell Sci. 107, 3105-3114
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The 'prespore-like cells' of Dictyostelium have ceased to express a prespore gene: analysis using short-lived beta-galactosidases as reporters.
S Detterbeck, P Morandini, B Wetterauer, A Bachmair, K Fischer, and H. MacWilliams (1994)
Development 120, 2847-2855
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A Dictyostelium anterior-like cell mutant reveals sequential steps in the prespore prestalk differentiation pathway.
G Bichler and C. Weijer (1994)
Development 120, 2857-2868
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Characterization of a novel Dictyostelium discoideum prespore-specific gene, PspB, reveals conserved regulatory sequences.
J. Powell-Coffman and R. Firtel (1994)
Development 120, 1601-1611
   Abstract »    PDF »
A density-sensing factor controls development in Dictyostelium..
R Jain, I S Yuen, C R Taphouse, and R H Gomer (1992)
Genes & Dev. 6, 390-400
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Molecular Genetic Analysis of Signal Transduction Pathways Controlling Multicellular Development in Dictyostelium.
A.B. Cubitt, F. Carrel, S. Dharmawardhane, C. Gaskins, J. Hadwiger, P. Howard, S.K.O. Mann, K. Okaichi, K. Zhou, and R.A. Firtel (1992)
Cold Spring Harb Symp Quant Biol 57, 177-192
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Analysis of G alpha 4, a G-protein subunit required for multicellular development in Dictyostelium..
J A Hadwiger and R A Firtel (1992)
Genes & Dev. 6, 38-49
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cAMP and cell sorting control the spatial expression of a developmentally essential cell-type-specific ras gene in Dictyostelium..
R K Esch and R A Firtel (1991)
Genes & Dev. 5, 9-21
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A spatial gradient of expression of a cAMP-regulated prespore cell-type-specific gene in Dictyostelium..
L Haberstroh and R A Firtel (1990)
Genes & Dev. 4, 596-612
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A Protein Containing a Serine-rich Domain with Vesicle Fusing Properties Mediates Cell Cycle-dependent Cytosolic pH Regulation.
D. T. Brazill, D. R. Caprette, H. A. Myler, R. D. Hatton, R. R. Ammann, D. F. Lindsey, D. A. Brock, and R. H. Gomer (2000)
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