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Science 3 July 1987:
Vol. 237. no. 4810, pp. 67 - 70
DOI: 10.1126/science.3603010
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Articles

Science, Vol 237, Issue 4810, 67-70
Copyright © 1987 by American Association for the Advancement of Science

articles

A Mab to a unique cerebellar neuron generated by immunosuppression and rapid immunization

S Hockfield

The cerebellar cortex is perhaps the best characterized structure in the mammalian central nervous system. Although the major cerebellar cell classes are well known, a new class of cerebellar cortical neuron has now been identified with a monoclonal antibody (Mab) generated by a procedure for rapid immunization and selective immunosuppression of antibody responses. This procedure generates a high frequency of immunoglobulin G-class antibodies of desired specificity, and has allowed the generation of two antibodies that recognize subsets of cerebellar cortical neurons. One of these antibodies defines a previously unrecognized class of cerebellar neuron. The distribution and antigenic characteristics of this neuron suggest that it has a distinct role in cerebellar circuitry.


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