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Science 3 July 1987:
Vol. 237. no. 4810, pp. 64 - 67
DOI: 10.1126/science.2955517
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Articles
Science, Vol 237, Issue 4810, 64-67
Copyright © 1987 by American Association for the Advancement of Science
Structurally divergent human T cell receptor gamma proteins encoded by distinct C gamma genes
MS Krangel,
H Band,
S Hata,
J McLean,
and
MB Brenner
The human T cell receptor (TCR) gamma polypeptide occurs in structurally distinct forms on certain peripheral blood T lymphocytes. Complementary DNA clones representing the transcripts of functionally rearranged TCR gamma genes in these cells have been analyzed. The expression of a disulfide-linked and a nondisulfide-linked form of TCR gamma correlates with the use of the C gamma 1 and C gamma 2 constant-region gene segments, respectively. Variability in TCR gamma polypeptide size and disulfide linkage is determined by the number of copies and the sequence of a repeated segment of the constant region. Thus C gamma 1 and C gamma 2 are used to generate structurally distinct, yet functional, T3-associated receptor complexes on peripheral blood lymphocytes. Tryptic peptide mapping suggests that the T3-associated TCR gamma and delta peptides in the nondisulfide-linked form are distinct.
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