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Science 26 June 1987:
Vol. 236. no. 4809, pp. 1671 - 1674
DOI: 10.1126/science.3037694
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Articles

Science, Vol 236, Issue 4809, 1671-1674
Copyright © 1987 by American Association for the Advancement of Science

articles

Retroviruses and mouse embryos: a rapid model for neurovirulence and transplacental antiviral therapy

AH Sharpe, R Jaenisch, and RM Ruprecht

A murine model in which neurotropic retroviral infection can be studied over short periods of time was developed. Microinjection of Cas-Br-E virus into midgestation mouse embryos caused paralysis and death within 25 days after birth, in contrast to virus-infected neonates which develop disease only after 4 months. To evaluate whether antiviral drugs could cross the placental barrier and influence the course of the disease, the drug 3'-azido-3'-deoxythymidine (AZT) was administered to infected embryos through the drinking water of pregnant females. AZT treatment markedly retarded the onset and course of virus-induced central nervous system disease, permitting animals to survive beyond 4 months of age. These results are evidence for effective antiviral treatment during gestation and in the perinatal period and are of potential significance for the management of maternal transmission of the acquired immune deficiency syndrome (AIDS) virus.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Reduction of Maternal-Infant Transmission of Human Immunodeficiency Virus Type 1 with Zidovudine Treatment.
E. M. Connor, R. S. Sperling, R. Gelber, P. Kiselev, G. Scott, M. J. O'Sullivan, R. VanDyke, M. Bey, W. Shearer, R. L. Jacobson, et al. (1994)
N. Engl. J. Med. 331, 1173-1180
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Antiretroviral Therapy in AIDS.
S. Broder, H. Mitsuya, R. Yarchoan, and G. N. Pavlakis (1990)
Ann Intern Med 113, 604-618
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Allogeneic Bone Marrow Transplantation, Zidovudine, and Human Immunodeficiency Virus Type 1 (HIV-I) Infection: Studies in a Patient with Non-Hodgkin Lymphoma.
H. K. Holland, R. Saral, J. J. Rossi, A. D. Donnenberg, W. H. Burns, W. E. Beschorner, H. Farzadegan, R. J. Jones, G. V. Quinnan, G. B. Vogelsang, et al. (1989)
Ann Intern Med 111, 973-981
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Testing Source Patient Blood for HIV Antibodies After Accidental Exposure of Health Care Workers to Blood and Body Fluids.
S. Bauer (1989)
JAMA 262, 1470-1471
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Prospects for Prevention of and Early Intervention Against HIV.
D. P. Bolognesi (1989)
JAMA 261, 3007-3013
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Amplification and molecular cloning of HTLV-I sequences from DNA of multiple sclerosis patients.
E. Reddy, M Sandberg-Wollheim, R. Mettus, P. Ray, E DeFreitas, and H Koprowski (1989)
Science 243, 529-533
   Abstract »    PDF »


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