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Science 5 June 1987:
Vol. 236. no. 4806, pp. 1295 - 1299
DOI: 10.1126/science.3495884
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Articles

Science, Vol 236, Issue 4806, 1295-1299
Copyright © 1987 by American Association for the Advancement of Science

articles

Regulation of bcl-2 proto-oncogene expression during normal human lymphocyte proliferation

JC Reed, Y Tsujimoto, JD Alpers, CM Croce, and PC Nowell

The bcl-2 and c-myc proto-oncogenes are brought into juxtaposition with the immunoglobulin heavy chain locus in particular B-cell lymphomas, resulting in high levels of constitutive accumulation of their messenger RNAs. Precisely how the products of the bcl-2 and c-myc genes contribute to tumorigenesis is unknown, but observations that c-myc expression is rapidly induced in nonneoplastic lymphocytes upon stimulation of proliferation raise the possibility that this proto-oncogene is involved in the control of normal cellular growth. In addition to c-myc, the bcl-2 proto-oncogene also was expressed in normal human B and T lymphocytes after stimulation with appropriate mitogens. Comparison of the regulation of the expression of these proto-oncogenes demonstrated marked differences and provided evidence that, in contrast to c-myc, levels of bcl-2 messenger RNA are regulated primarily through transcriptional mechanisms.


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Science. ISSN 0036-8075 (print), 1095-9203 (online)