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Science 5 June 1987: Vol. 236. no. 4806, pp. 1237 - 1245 DOI: 10.1126/science.3296191
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Articles
Science, Vol 236, Issue 4806, 1237-1245
Copyright © 1987 by American Association for the Advancement of Science
Regulation of inducible and tissue-specific gene expression
T Maniatis,
S Goodbourn,
and
JA Fischer
Molecular genetics approaches have been used to identify and characterize cis-acting DNA sequences required for eukaryotic gene regulation. These sequences are modular in nature, consisting of arrays of short (10- to 12-base pair) recognition elements that interact with specific transcription factors. Some transcription factors have been extensively purified and the corresponding genes have been cloned, but the mechanisms by which they promote transcription are not yet understood. Positive and negative regulatory elements that function only in specific cell types or in response to extracellular inducers have been identified. A number of cases of inducible and tissue-specific gene expression involve the activation of preexisting transcription factors, rather than the synthesis of new proteins. This activation may involve covalent modification of the protein or an allosteric change in its structure. The modification of regulatory proteins may play a central role in the mechanisms of eukaryotic gene regulation.
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- Distinct cloned class II MHC DNA binding proteins recognize the X box transcription element.
- H. Liou, M. Boothby, and L. Glimcher (1988)
Science
242, 69-71
| Abstract »
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- Octamer-binding proteins from B or HeLa cells stimulate transcription of the immunoglobulin heavy-chain promoter in vitro..
- J H LeBowitz, T Kobayashi, L Staudt, D Baltimore, and P A Sharp (1988)
Genes & Dev.
2, 1227-1237
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- Physical analysis of transcription preinitiation complex assembly on a class II gene promoter.
- M. Van Dyke, R. Roeder, and M Sawadogo (1988)
Science
241, 1335-1338
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- Transcription factor OTF-1 is functionally identical to the DNA replication factor NF-III.
- E. O'Neill, C Fletcher, C. Burrow, N Heintz, R. Roeder, and T. Kelly (1988)
Science
241, 1210-1213
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- Gene Regulation in the Development of Oral Tissues.
- H.C. Slavkin (1988)
Journal of Dental Research
67, 1142-1149
| Abstract »
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- Mammalian glucocorticoid receptor derivatives enhance transcription in yeast.
- M Schena and K. Yamamoto (1988)
Science
241, 965-967
| Abstract »
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- Selective activation of transcription by a novel CCAAT binding factor.
- S. Maity, P. Golumbek, G Karsenty, and B de Crombrugghe (1988)
Science
241, 582-585
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