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Science 5 June 1987:
Vol. 236. no. 4806, pp. 1229 - 1237
DOI: 10.1126/science.3296190

Articles

Science, Vol 236, Issue 4806, 1229-1237
Copyright © 1987 by American Association for the Advancement of Science


articles

The human hematopoietic colony-stimulating factors

SC Clark and R Kamen

The complementary DNAs and genes encoding the four major human myeloid growth factors--granulocyte colony-stimulating factor, macrophage colony-stimulating factor, granulocyte-macrophage colony-stimulating factor, and interleukin-3--have all been molecularly cloned. These DNA clones have proved valuable for studying the molecular biology of these important regulatory molecules as well as for the large-scale production of the recombinant growth factor proteins. These advances have led to a much better understanding of the role of the myeloid growth factors in regulating hematopoiesis in vivo that should soon find practical application in clinical medicine.


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Control of hematopoietic differentiation: Lack of specificity in signaling by cytokine receptors.
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Chronopharmacology of Granulocyte Colony-Stimulating Factor in Mice.
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Increased Mucosal B-Lymphocyte Apoptosis During Polymicrobial Sepsis Is a Fas Ligand But Not an Endotoxin-Mediated Process.
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Blood 91, 1362-1372
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Multiple Myeloma: Increasing Evidence for a Multistep Transformation Process.
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Blood 91, 3-21
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Smooth Muscle Cells Express Granulocyte-Macrophage Colony-Stimulating Factor in the Undiseased and Atherosclerotic Human Coronary Artery.
G. Plenz, C. Koenig, N. J. Severs, and H. Robenek (1997)
Arterioscler. Thromb. Vasc. Biol. 17, 2489-2499
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The Human Granulocyte-Macrophage Colony-Stimulating Factor (GM-CSF ) Receptor Exists as a Preformed Receptor Complex That Can Be Activated by GM-CSF, Interleukin-3, or Interleukin-5.
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Blood 90, 3005-3017
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Involvement of STAT3 in the Granulocyte Colony-stimulating Factor-induced Differentiation of Myeloid Cells.
K. Shimozaki, K. Nakajima, T. Hirano, and S. Nagata (1997)
J. Biol. Chem. 272, 25184-25189
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Anandamide, a Natural Ligand for the Peripheral Cannabinoid Receptor Is a Novel Synergistic Growth Factor for Hematopoietic Cells.
P. Valk, S. Verbakel, Y. Vankan, S. Hol, S. Mancham, R. Ploemacher, A. Mayen, B. Lowenberg, and R. Delwel (1997)
Blood 90, 1448-1457
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Amyloid-beta peptide-Receptor for Advanced Glycation Endproduct interaction elicits neuronal expression of macrophage-colony stimulating factor: A proinflammatory pathway in Alzheimer disease.
S. Du Yan, H. Zhu, J. Fu, S. F. Yan, A. Roher, W. W. Tourtellotte, T. Rajavashisth, X. Chen, G. C. Godman, D. Stern, et al. (1997)
PNAS 94, 5296-5301
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Expression of Small Extracellular Chondroitin/Dermatan Sulfate Proteoglycans Is Differentially Regulated in Human Endothelial Cells.
L. Nelimarkka, V. Kainulainen, E. Schonherr, S. Moisander, M. Jortikka, M. Lammi, K. Elenius, M. Jalkanen, and H. Jarvelainen (1997)
J. Biol. Chem. 272, 12730-12737
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A Discontinuous Eight-Amino Acid Epitope in Human Interleukin-3 Binds the alpha -Chain of Its Receptor.
C. J. Bagley, J. Phillips, B. Cambareri, M. A. Vadas, and A. F. Lopez (1996)
J. Biol. Chem. 271, 31922-31928
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Nerve Growth Factor Induces the Expression of Certain Cytokine Genes and bcl-2 in Mast Cells. POTENTIAL ROLE IN SURVIVAL PROMOTION.
E. D. Bullock and E. M. Johnson Jr. (1996)
J. Biol. Chem. 271, 27500-27508
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Interleukin-1{beta} and Tumor Necrosis Factor-{alpha} Stimulate Granulocyte Colony-Stimulating Factor Production by Placental Villous Core Mesenchymal Cells.
D. T. Vandermolen, S. W. Kauma, and T. T. Turner (1996)
Reproductive Sciences 3, 172-178
   Abstract »    PDF »
S6 Kinase p90rsk in Granulocyte-Macrophage Colony-stimulating Factor-stimulated Proliferative and Mature Hematopoietic Cells.
D. E. Joseph, C. C. Paul, M. A. Baumann, and J. Gomez-Cambronero (1996)
J. Biol. Chem. 271, 13088-13093
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Granulocyte-Macrophage Colony-stimulating Factor Stimulates JAK2 Signaling Pathway and Rapidly Activates p93[IMAGE], STAT1 p91, and STAT3 p92 in Polymorphonuclear Leukocytes.
M. F. Brizzi, M. G. Aronica, A. Rosso, G. P. Bagnara, Y. Yarden, and L. Pegoraro (1996)
J. Biol. Chem. 271, 3562-3567
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Keratinocytes and Cytokine/Growth Factors.
C. Feliciani, A.K. Gupta, and D.N. Saucier (1996)
Critical Reviews in Oral Biology & Medicine 7, 300-318
   Abstract »    Full Text »    PDF »
Multiple Proteins Interact with the Nuclear Inhibitory Protein Repressor Element in the Human Interleukin-3 Promoter.
K. Engeland, N. C. Andrews, and B. Mathey-Prevot (1995)
J. Biol. Chem. 270, 24572-24579
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Preeclampsia Is Associated with Decreased Placental Interleukin-6 Production.
S. W. Kauma, Y. Wang, and S. W. Walsh (1995)
Reproductive Sciences 2, 614-617
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Effects of Platelet-Derived Growth Factor on the Synthesis of Lipoprotein Lipase in Human Monocyte–Derived Macrophages.
T. Inaba, M. Kawamura, T. Gotoda, K. Harada, M. Shimada, J.-i. Ohsuga, H. Shimano, Y. Akanuma, Y. Yazaki, and N. Yamada (1995)
Arterioscler. Thromb. Vasc. Biol. 15, 522-528
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Identification and behavior of epithelial stem cells in the Drosophila ovary.
J Margolis and A Spradling (1995)
Development 121, 3797-3807
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Using Granulocyte Colony-Stimulating Factor for Neutropenia During Neonatal Sepsis.
J. C. Murray, K. L. McClain, and M. E. Wearden (1994)
Arch Pediatr Adolesc Med 148, 764-766
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Three-dimensional structure of dimeric human recombinant macrophage colony-stimulating factor.
J Pandit, A Bohm, J Jancarik, R Halenbeck, K Koths, and S. Kim (1992)
Science 258, 1358-1362
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Cutaneous Reactions to Granulocyte-Monocyte Colony-Stimulating Factor.
D. R. Mehregan, A. F. Fransway, J. H. Edmonson, and K. M. Leiferman (1992)
Arch Dermatol 128, 1055-1059
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Myelokathexis: Normalization of Neutrophil Counts and Morphology by GM-CSF.
M. Wetzler, M. Talpaz, M. J. Kellagher, J. U. Gutterman, and R. Kurzrock (1992)
JAMA 267, 2179-2180
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Novel fold and putative receptor binding site of granulocyte-macrophage colony-stimulating factor.
K Diederichs, T Boone, and P. Karplus (1991)
Science 254, 1779-1782
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Control of granulocytes and macrophages: molecular, cellular, and clinical aspects.
D Metcalf (1991)
Science 254, 529-533
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Biological Agents in Infectious Diseases.
S. G. Louie and G. S. Jaresko (1991)
Journal of Pharmacy Practice 4, 326-341
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Cutaneous Eruptions During GM-CSF Infusion: Clues for Cytokine Biology.
J. A. Schiro and T. S. Kupper (1991)
Arch Dermatol 127, 110-112
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"Pure" human hematopoietic progenitors: permissive action of basic fibroblast growth factor.
M Gabbianelli, M Sargiacomo, E Pelosi, U Testa, G Isacchi, and C Peschle (1990)
Science 249, 1561-1564
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Eosinophilic Infiltrates in Epidermolysis Bullosa.
R. R. Roth, K. J. Smith, and W. D. James (1990)
Arch Dermatol 126, 1191-1194
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Protective Effect of Recombinant Human Granulocyte Colony-Stimulating Factor Against Pneumococcal Infections in Splenectomized Mice.
J. C. Hebert, M. O'Reilly, and R. L. Gamelli (1990)
Arch Surg 125, 1075-1078
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The cholinergic neuronal differentiation factor from heart cells is identical to leukemia inhibitory factor.
T Yamamori, K Fukada, R Aebersold, S Korsching, M. Fann, and P. Patterson (1989)
Science 246, 1412-1416
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The Effect of Recombinant Human Granulocyte-Macrophage Colony-Stimulating Factor on Neutropenia and Related Morbidity in Chronic Severe Neutropenia.
A. Ganser, O. G. Ottmann, H. Erdmann, G. Schulz, and D. Hoelzer (1989)
Ann Intern Med 111, 887-892
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Colony-Stimulating Factors and Host Defense.
R. H. Weisbart, J. C. Gasson, and D. W. Golde (1989)
Ann Intern Med 110, 297-303
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Contingent genetic regulatory events in T lymphocyte activation.
G. Crabtree (1989)
Science 243, 355-361
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AIDS-Kaposi's sarcoma-derived cells express cytokines with autocrine and paracrine growth effects.
B Ensoli, S Nakamura, S. Salahuddin, P Biberfeld, L Larsson, B Beaver, F Wong-Staal, and R. Gallo (1989)
Science 243, 223-226
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Neonatal Neutrophil Host Defense: Prospects for Immunologic Enhancement During Neonatal Sepsis.
M. S. Cairo (1989)
Arch Pediatr Adolesc Med 143, 40-46
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Novel regulators of bone formation: molecular clones and activities.
J. Wozney, V Rosen, A. Celeste, L. Mitsock, M. Whitters, R. Kriz, R. Hewick, and E. Wang (1988)
Science 242, 1528-1534
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Therapy for Neutropenia in Hairy Cell Leukemia with Recombinant Human Granulocyte Colony-Stimulating Factor.
J. A. Glaspy, G. C. Baldwin, P. A. Robertson, L. Souza, M. Vincent, J. Ambersley, and D. W. Golde (1988)
Ann Intern Med 109, 789-795
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Recombinant Human Granulocyte Colony-Stimulating Factor and Pseudomonas Burn Wound Sepsis.
D. P. Mooney, R. L. Gamelli, M. O'Reilly, and J. C. Hebert (1988)
Arch Surg 123, 1353-1357
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Human IL-3 and GM-CSF act synergistically in stimulating hematopoiesis in primates.
R. Donahue, J Seehra, M Metzger, D Lefebvre, B Rock, S Carbone, D. Nathan, M Garnick, P. Sehgal, D Laston, et al. (1988)
Science 241, 1820-1823
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Cytokines alter production of HIV-1 from primary mononuclear phagocytes.
Y Koyanagi, W. O'Brien, J. Zhao, D. Golde, J. Gasson, and I. Chen (1988)
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The human immunodeficiency virus: infectivity and mechanisms of pathogenesis.
A. Fauci (1988)
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Macrophage Colony-stimulating Factor, CSF-1, and Its Proto-oncogene-encoded Receptor.
C. J. Sherr, C.W. Rettenmier, and M.F. Roussel (1988)
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The molecular control of blood cell development.
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