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Science 5 June 1987: Vol. 236. no. 4806, pp. 1229 - 1237 DOI: 10.1126/science.3296190
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Articles
Science, Vol 236, Issue 4806, 1229-1237
Copyright © 1987 by American Association for the Advancement of Science
The human hematopoietic colony-stimulating factors
SC Clark
and
R Kamen
The complementary DNAs and genes encoding the four major human myeloid growth factors--granulocyte colony-stimulating factor, macrophage colony-stimulating factor, granulocyte-macrophage colony-stimulating factor, and interleukin-3--have all been molecularly cloned. These DNA clones have proved valuable for studying the molecular biology of these important regulatory molecules as well as for the large-scale production of the recombinant growth factor proteins. These advances have led to a much better understanding of the role of the myeloid growth factors in regulating hematopoiesis in vivo that should soon find practical application in clinical medicine.
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