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Science 29 May 1987:
Vol. 236. no. 4805, pp. 1120 - 1122
DOI: 10.1126/science.3576227
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Articles

Science, Vol 236, Issue 4805, 1120-1122
Copyright © 1987 by American Association for the Advancement of Science

articles

Expression of the multidrug-resistant gene in hepatocarcinogenesis and regenerating rat liver

SS Thorgeirsson, BE Huber, S Sorrell, A Fojo, I Pastan, and MM Gottesman

Preneoplastic and neoplastic liver nodules and hepatocytes isolated from regenerating rat liver have been shown to be resistant to a broad range of carcinogenic agents. This phenomenon was studied by measuring the expression of the multidrug-resistant (mdr) gene in normal liver cells and in preneoplastic and neoplastic nodules and regenerating liver. Levels of messenger RNA for the mdr gene, which encodes P-glycoprotein, were elevated in both preneoplastic and neoplastic lesions. Expression of the mdr gene also reached high levels in regenerating rat liver 24 to 72 hours after partial hepatectomy. These results show that the expression of the mdr gene can be regulated in liver and is likely to be responsible for part of the multidrug-resistance phenotype of carcinogen-initiated hepatocytes and regenerating liver cells.


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Identification and Characterization of a Hepatoma Cell-specific Enhancer in the Mouse Multidrug Resistance mdr1b Promoter.
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Functional expression of yeast artificial chromosome-human multidrug resistance genes in mouse cells..
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Modulation of activity of the promoter of the human MDR1 gene by Ras and p53.
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