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Science 22 May 1987:
Vol. 236. no. 4804, pp. 944 - 947
DOI: 10.1126/science.3107127

Articles

Science, Vol 236, Issue 4804, 944-947
Copyright © 1987 by American Association for the Advancement of Science


articles

Interferon-gamma and B cell stimulatory factor-1 reciprocally regulate Ig isotype production

CM Snapper and WE Paul

Gamma interferon (IFN-gamma) and B cell stimulatory factor-1 (BSF-1), also known as interleukin-4, are T cell-derived lymphokines that have potent effects on B cell proliferation and differentiation. They are often secreted by distinct T cell clones. It is now shown that IFN-gamma stimulates the expression of immunoglobulin (Ig) of the IgG2a isotype and inhibits the production of IgG3, IgG1, IgG2b, and IgE. By contrast, BSF-1 has powerful effects in promoting switching to the expression of IgG1 and IgE but markedly inhibits IgM, IgG3, IgG2a, and IgG2b. These results indicate that BSF-1 and IFN-gamma as well as the T cells that produce them may act as reciprocal regulatory agents in the determination of Ig isotype responses. The effects of IFN-gamma and BSF-1 on isotype expression are independent.


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   Abstract »    Full Text »    PDF »
Interferon-gamma Deficiency Attenuates Local P. gingivalis-induced Inflammation.
Y. Houri-Haddad, W.A. Soskolne, E. Shai, A. Palmon, and L. Shapira (2002)
Journal of Dental Research 81, 395-398
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Toll-Like Receptor 4 Is Required for Optimal Development of Th2 Immune Responses: Role of Dendritic Cells.
K. Dabbagh, M. E. Dahl, P. Stepick-Biek, and D. B. Lewis (2002)
J. Immunol. 168, 4524-4530
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T-bet regulates IgG class switching and pathogenic autoantibody production.
S. L. Peng, S. J. Szabo, and L. H. Glimcher (2002)
PNAS 99, 5545-5550
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Temporal Effects of Gamma Interferon Deficiency on the Course of Friend Retrovirus Infection in Mice.
I. M. Stromnes, U. Dittmer, T. N. M. Schumacher, K. Schepers, R. J. Messer, L. H. Evans, K. E. Peterson, B. Race, and K. J. Hasenkrug (2002)
J. Virol. 76, 2225-2232
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Distinct Role of CD80 and CD86 in the Regulation of the Activation of B Cell and B Cell Lymphoma.
S. Suvas, V. Singh, S. Sahdev, H. Vohra, and J. N. Agrewala (2002)
J. Biol. Chem. 277, 7766-7775
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Endogenous Pro- and Anti-Inflammatory Cytokines Differentially Regulate an In Vivo Humoral Response to Streptococcus pneumoniae.
A. Q. Khan, Y. Shen, Z.-Q. Wu, T. A. Wynn, and C. M. Snapper (2002)
Infect. Immun. 70, 749-761
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BCR signal through {alpha}4 is involved in S6 kinase activation and required for B cell maturation including isotype switching and V region somatic hypermutation.
S. Inui, K. Maeda, D. R. Hua, T. Yamashita, H. Yamamoto, E. Miyamoto, S. Aizawa, and N. Sakaguchi (2002)
Int. Immunol. 14, 177-187
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Ragweed-induced expression of GATA-3, IL-4, and IL-5 by eosinophils in the lungs of allergic C57BL/6J mice.
J. P. Justice, M. T. Borchers, J. J. Lee, W. H. Rowan, Y. Shibata, and M. R. Van Scott (2002)
Am J Physiol Lung Cell Mol Physiol 282, L302-L309
   Abstract »    Full Text »    PDF »
Indirect IL-4 Pathway in Type 1 Immunity.
A. Y. Karulin, M. D. Hesse, H. C. Yip, and P. V. Lehmann (2002)
J. Immunol. 168, 545-553
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Leptin Signaling Deficiency Impairs Humoral and Cellular Immune Responses and Attenuates Experimental Arthritis.
N. Busso, A. So, V. Chobaz-Peclat, C. Morard, E. Martinez-Soria, D. Talabot-Ayer, and C. Gabay (2002)
J. Immunol. 168, 875-882
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Persistent Ehrlichia chaffeensis Infection Occurs in the Absence of Functional Major Histocompatibility Complex Class II Genes.
R. R. Ganta, M. J. Wilkerson, C. Cheng, A. M. Rokey, and S. K. Chapes (2002)
Infect. Immun. 70, 380-388
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CD8 T Cells Inhibit IgE Via Dendritic Cell IL-12 Induction That Promotes Th1 T Cell Counter-Regulation.
M. J. Thomas, A. Noble, E. Sawicka, P. W. Askenase, and D. M. Kemeny (2002)
J. Immunol. 168, 216-223
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Dendritic Cells Pulsed with Intact Streptococcus pneumoniae Elicit both Protein- and Polysaccharide-specific Immunoglobulin Isotype Responses In Vivo through Distinct Mechanisms.
J. Colino, Y. Shen, and C. M. Snapper (2001)
J. Exp. Med. 195, 1-14
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Th1 Adjuvant N-Acetyl-D-Glucosamine Polymer Up-Regulates Th1 Immunity but Down-Regulates Th2 Immunity against a Mycobacterial Protein (MPB-59) in Interleukin-10-Knockout and Wild-Type Mice.
Y. Shibata, I. Honda, J. P. Justice, M. R. Van Scott, R. M. Nakamura, and Q. N. Myrvik (2001)
Infect. Immun. 69, 6123-6130
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Ontogeny of Th1 Memory Responses against a Brucella abortus Conjugate.
O. Scharf, I. Agranovich, K. Lee, N. L. Eller, L. Levy, J. Inman, D. E. Scott, and B. Golding (2001)
Infect. Immun. 69, 5417-5422
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IFN-{gamma}-Dependent and -Independent Initiation of Switch Recombination by NK Cells.
N. Gao, T. Dang, and D. Yuan (2001)
J. Immunol. 167, 2011-2018
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Enforced Expression of GATA-3 in Transgenic Mice Inhibits Th1 Differentiation and Induces the Formation of a T1/ST2-Expressing Th2-Committed T Cell Compartment In Vivo.
M. C. Nawijn, G. M. Dingjan, R. Ferreira, B. N. Lambrecht, A. Karis, F. Grosveld, H. Savelkoul, and R. W. Hendriks (2001)
J. Immunol. 167, 724-732
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Complement Contributes to Protective Immunity against Reinfection by Plasmodium chabaudi chabaudi Parasites.
P. R. Taylor, E. Seixas, M. J. Walport, J. Langhorne, and M. Botto (2001)
Infect. Immun. 69, 3853-3859
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A Critical Role of Fc Receptor-Mediated Antibody-Dependent Phagocytosis in the Host Resistance to Blood-Stage Plasmodium berghei XAT Infection.
T. Yoneto, S. Waki, T. Takai, Y.-i. Tagawa, Y. Iwakura, J. Mizuguchi, H. Nariuchi, and T. Yoshimoto (2001)
J. Immunol. 166, 6236-6241
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The Mechanism of a Defective IFN-{{gamma}} Response to Bacterial Toxins in an Atopic Dermatitis Model, NC/Nga Mice, and the Therapeutic Effect of IFN-{{gamma}}, IL-12, or IL-18 on Dermatitis.
Y. Habu, S. Seki, E. Takayama, T. Ohkawa, Y. Koike, K. Ami, T. Majima, and H. Hiraide (2001)
J. Immunol. 166, 5439-5447
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