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Science 22 May 1987: Vol. 236. no. 4804, pp. 944 - 947 DOI: 10.1126/science.3107127
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Articles
Science, Vol 236, Issue 4804, 944-947
Copyright © 1987 by American Association for the Advancement of Science
Interferon-gamma and B cell stimulatory factor-1 reciprocally regulate Ig isotype production
CM Snapper
and
WE Paul
Gamma interferon (IFN-gamma) and B cell stimulatory factor-1 (BSF-1), also known as interleukin-4, are T cell-derived lymphokines that have potent effects on B cell proliferation and differentiation. They are often secreted by distinct T cell clones. It is now shown that IFN-gamma stimulates the expression of immunoglobulin (Ig) of the IgG2a isotype and inhibits the production of IgG3, IgG1, IgG2b, and IgE. By contrast, BSF-1 has powerful effects in promoting switching to the expression of IgG1 and IgE but markedly inhibits IgM, IgG3, IgG2a, and IgG2b. These results indicate that BSF-1 and IFN-gamma as well as the T cells that produce them may act as reciprocal regulatory agents in the determination of Ig isotype responses. The effects of IFN-gamma and BSF-1 on isotype expression are independent.
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J. Immunol.
169, 5458-5467
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- Adjuvant Activity of Emulsan, a Secreted Lipopolysaccharide from Acinetobacter calcoaceticus.
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Clin. Vaccine Immunol.
9, 1240-1247
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- Amelioration of Collagen-Induced Arthritis by Blockade of Inducible Costimulator-B7 Homologous Protein Costimulation.
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J. Immunol.
169, 4332-4339
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- Enhanced Immunogenicity of Pneumococcal Surface Adhesin A by Genetic Fusion to Cytokines and Evaluation of Protective Immunity in Mice.
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Infect. Immun.
70, 5589-5595
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- Successful Boosting of a DNA Measles Immunization with an Oral Plant-Derived Measles Virus Vaccine.
- D. E. Webster, M. L. Cooney, Z. Huang, D. R. Drew, I. A. Ramshaw, I. B. Dry, R. A. Strugnell, J. L. Martin, and S. L. Wesselingh (2002)
J. Virol.
76, 7910-7912
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- Interferon-gamma Deficiency Attenuates Local P. gingivalis-induced Inflammation.
- Y. Houri-Haddad, W.A. Soskolne, E. Shai, A. Palmon, and L. Shapira (2002)
Journal of Dental Research
81, 395-398
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- Toll-Like Receptor 4 Is Required for Optimal Development of Th2 Immune Responses: Role of Dendritic Cells.
- K. Dabbagh, M. E. Dahl, P. Stepick-Biek, and D. B. Lewis (2002)
J. Immunol.
168, 4524-4530
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- T-bet regulates IgG class switching and pathogenic autoantibody production.
- S. L. Peng, S. J. Szabo, and L. H. Glimcher (2002)
PNAS
99, 5545-5550
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- Temporal Effects of Gamma Interferon Deficiency on the Course of Friend Retrovirus Infection in Mice.
- I. M. Stromnes, U. Dittmer, T. N. M. Schumacher, K. Schepers, R. J. Messer, L. H. Evans, K. E. Peterson, B. Race, and K. J. Hasenkrug (2002)
J. Virol.
76, 2225-2232
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- Distinct Role of CD80 and CD86 in the Regulation of the Activation of B Cell and B Cell Lymphoma.
- S. Suvas, V. Singh, S. Sahdev, H. Vohra, and J. N. Agrewala (2002)
J. Biol. Chem.
277, 7766-7775
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- Endogenous Pro- and Anti-Inflammatory Cytokines Differentially Regulate an In Vivo Humoral Response to Streptococcus pneumoniae.
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Infect. Immun.
70, 749-761
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- BCR signal through {alpha}4 is involved in S6 kinase activation and required for B cell maturation including isotype switching and V region somatic hypermutation.
- S. Inui, K. Maeda, D. R. Hua, T. Yamashita, H. Yamamoto, E. Miyamoto, S. Aizawa, and N. Sakaguchi (2002)
Int. Immunol.
14, 177-187
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- Ragweed-induced expression of GATA-3, IL-4, and IL-5 by eosinophils in the lungs of allergic C57BL/6J mice.
- J. P. Justice, M. T. Borchers, J. J. Lee, W. H. Rowan, Y. Shibata, and M. R. Van Scott (2002)
Am J Physiol Lung Cell Mol Physiol
282, L302-L309
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- Indirect IL-4 Pathway in Type 1 Immunity.
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J. Immunol.
168, 545-553
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- Leptin Signaling Deficiency Impairs Humoral and Cellular Immune Responses and Attenuates Experimental Arthritis.
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J. Immunol.
168, 875-882
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- Persistent Ehrlichia chaffeensis Infection Occurs in the Absence of Functional Major Histocompatibility Complex Class II Genes.
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Infect. Immun.
70, 380-388
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- CD8 T Cells Inhibit IgE Via Dendritic Cell IL-12 Induction That Promotes Th1 T Cell Counter-Regulation.
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J. Immunol.
168, 216-223
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- Dendritic Cells Pulsed with Intact Streptococcus pneumoniae Elicit both Protein- and Polysaccharide-specific Immunoglobulin Isotype Responses In Vivo through Distinct Mechanisms.
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J. Exp. Med.
195, 1-14
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- Th1 Adjuvant N-Acetyl-D-Glucosamine Polymer Up-Regulates Th1 Immunity but Down-Regulates Th2 Immunity against a Mycobacterial Protein (MPB-59) in Interleukin-10-Knockout and Wild-Type Mice.
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Infect. Immun.
69, 6123-6130
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- Ontogeny of Th1 Memory Responses against a Brucella abortus Conjugate.
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Infect. Immun.
69, 5417-5422
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- IFN-{gamma}-Dependent and -Independent Initiation of Switch Recombination by NK Cells.
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J. Immunol.
167, 2011-2018
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- Enforced Expression of GATA-3 in Transgenic Mice Inhibits Th1 Differentiation and Induces the Formation of a T1/ST2-Expressing Th2-Committed T Cell Compartment In Vivo.
- M. C. Nawijn, G. M. Dingjan, R. Ferreira, B. N. Lambrecht, A. Karis, F. Grosveld, H. Savelkoul, and R. W. Hendriks (2001)
J. Immunol.
167, 724-732
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- Complement Contributes to Protective Immunity against Reinfection by Plasmodium chabaudi chabaudi Parasites.
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Infect. Immun.
69, 3853-3859
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- A Critical Role of Fc Receptor-Mediated Antibody-Dependent Phagocytosis in the Host Resistance to Blood-Stage Plasmodium berghei XAT Infection.
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J. Immunol.
166, 6236-6241
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- The Mechanism of a Defective IFN-{{gamma}} Response to Bacterial Toxins in an Atopic Dermatitis Model, NC/Nga Mice, and the Therapeutic Effect of IFN-{{gamma}}, IL-12, or IL-18 on Dermatitis.
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J. Immunol.
166, 5439-5447
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