Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Science 15 May 1987:
Vol. 236. no. 4803, pp. 843 - 845
DOI: 10.1126/science.2437656
Prev | Table of Contents | Next

Articles

Science, Vol 236, Issue 4803, 843-845
Copyright © 1987 by American Association for the Advancement of Science

articles

Chemical identification of a tumor-derived angiogenic factor

FC Kull Jr, DA Brent, I Parikh, and P Cuatrecasas

Neoplasms produce substances that induce blood vessel formation (angiogenesis). Fractions from ethanol extracts of the Walker 256 carcinoma were isolated by silica column chromatography and C18 reversed-phase high-performance liquid chromatography. Two of the isolated fractions induced neovascularization when tested in the rabbit corneal micropocket assay. One of the fractions was identified as nicotinamide by desorption-electron impact mass spectrometry, nuclear magnetic resonance spectroscopy, and gas chromatography-mass spectrometry. The second active fraction contained nicotinamide as part of a more complex, as yet unidentified, molecular arrangement. Microgram quantities of commercial nicotinamide induced neovascularization in the corneal micropocket assay and in the chick chorioallantoic membrane assay.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Angiogenesis and the ischaemic heart.
R Tabibiazar and S.G Rockson (2001)
Eur. Heart J. 22, 903-918
   PDF »
Improvement of Pharmacological Properties of Protein-Drugs by Tailoring with Synthetic Polymers.
H. Maeda, T. Oda, Y. Matsumura, and M. Kimura (1988)
Journal of Bioactive and Compatible Polymers 3, 27-43
   PDF »
Mechanisms of normal and tumor-derived angiogenesis.
M. Papetti and I. M. Herman (2002)
Am J Physiol Cell Physiol 282, C947-C970
   Abstract »    Full Text »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)