Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Site Tools

  • AAAS
  • Subscribe
  • Feedback

Site Search

Search Advanced

Science 15 May 1987:
Vol. 236. no. 4803, pp. 799 - 806
DOI: 10.1126/science.3576199
Prev | Table of Contents | Next

Articles

Science, Vol 236, Issue 4803, 799-806
Copyright © 1987 by American Association for the Advancement of Science

articles

Neural cell adhesion molecule: structure, immunoglobulin-like domains, cell surface modulation, and alternative RNA splicing

BA Cunningham, JJ Hemperly, BA Murray, EA Prediger, R Brackenbury, and GM Edelman

The neural cell adhesion molecule, N-CAM, appears on early embryonic cells and is important in the formation of cell collectives and their boundaries at sites of morphogenesis. Later in development it is found on various differentiated tissues and is a major CAM mediating adhesion among neurons and between neurons and muscle. To provide a molecular basis for understanding N-CAM function, the complete amino acid sequences of the three major polypeptides of N-CAM and most of the noncoding sequences of their messenger RNA's were determined from the analysis of complementary DNA clones and were verified by amino acid sequences of selected CNBr fragments and proteolytic fragments. The extracellular region of each N-CAM polypeptide includes five contiguous segments that are homologous in sequence to each other and to members of the immunoglobulin superfamily, suggesting that interactions among immunoglobulin-like domains form the basis for N-CAM homophilic binding. Although different in their membrane-associated and cytoplasmic domains, the amino acid sequences of the three polypeptides appear to be identical throughout this extracellular region (682 amino acids) where the binding site is located. Variations in N-CAM activity thus do not occur by changes in the amino acid sequence that alter the specificity of binding. Instead, regulation is achieved by cell surface modulation events that alter N-CAM affinity, prevalence, mobility, and distribution on the surface. A major mechanism for modulation is alternative RNA splicing resulting in N-CAM's with different cytoplasmic domains that differentially interact with the cell membrane. Such regulatory mechanisms may link N-CAM binding function with other primary cellular processes during the embryonic development of pattern.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Impaired Insulin Exocytosis in Neural Cell Adhesion Molecule-/- Mice Due to Defective Reorganization of the Submembrane F-Actin Network.
C. S. Olofsson, J. Hakansson, A. Salehi, M. Bengtsson, J. Galvanovskis, C. Partridge, M. SorhedeWinzell, X. Xian, L. Eliasson, I. Lundquist, et al. (2009)
Endocrinology 150, 3067-3075
   Abstract »    Full Text »    PDF »
Modular Design of Immunological Synapses and Kinapses.
M. L. Dustin (2009)
Cold Spring Harb. Perspect. Biol. 1, a002873
   Abstract »    Full Text »    PDF »
Identification of Sequences in the Polysialyltransferases ST8Sia II and ST8Sia IV That Are Required for the Protein-specific Polysialylation of the Neural Cell Adhesion Molecule, NCAM.
D. A. Foley, K. G. Swartzentruber, and K. J. Colley (2009)
J. Biol. Chem. 284, 15505-15516
   Abstract »    Full Text »    PDF »
Neuronal cell depolarization induces intragenic chromatin modifications affecting NCAM alternative splicing.
I. E. Schor, N. Rascovan, F. Pelisch, M. Allo, and A. R. Kornblihtt (2009)
PNAS 106, 4325-4330
   Abstract »    Full Text »    PDF »
Fasciclin 2, the Drosophila orthologue of neural cell-adhesion molecule, inhibits EGF receptor signalling.
Y. Mao and M. Freeman (2009)
Development 136, 473-481
   Abstract »    Full Text »    PDF »
Cell Surface Proteomics Identifies Molecules Functionally Linked to Tumor Cell Intravasation.
E. M. Conn, M. A. Madsen, B. F. Cravatt, W. Ruf, E. I. Deryugina, and J. P. Quigley (2008)
J. Biol. Chem. 283, 26518-26527
   Abstract »    Full Text »    PDF »
Distribution of neural cell adhesion molecule (NCAM/CD56) in gastrointestinal stromal tumours and their intra-abdominal mesenchymal mimics.
A Agaimy and P H Wunsch (2008)
J. Clin. Pathol. 61, 499-503
   Abstract »    Full Text »    PDF »
Selective Targeting of Different Neural Cell Adhesion Molecule Isoforms during Motoneuron Myotube Synapse Formation in Culture and the Switch from an Immature to Mature Form of Synaptic Vesicle Cycling.
K. Hata, L. Polo-Parada, and L. T. Landmesser (2007)
J. Neurosci. 27, 14481-14493
   Abstract »    Full Text »    PDF »
Association of haplotypic variants in DRD2, ANKK1, TTC12 and NCAM1 to alcohol dependence in independent case control and family samples.
B.-Z. Yang, H. R. Kranzler, H. Zhao, J. R. Gruen, X. Luo, and J. Gelernter (2007)
Hum. Mol. Genet. 16, 2844-2853
   Abstract »    Full Text »    PDF »
Ossifying Fibromyxoid Tumor May Express CD56 and CD99: A Case Report.
D. Miliaras, S. Meditskou, and M. Ketikidou (2007)
International Journal of Surgical Pathology 15, 437-440
   Abstract »    PDF »
Human hepatic stem cells from fetal and postnatal donors.
E. Schmelzer, L. Zhang, A. Bruce, E. Wauthier, J. Ludlow, H.-l. Yao, N. Moss, A. Melhem, R. McClelland, W. Turner, et al. (2007)
J. Exp. Med. 204, 1973-1987
   Abstract »    Full Text »    PDF »
Expression and Subcellular Localization of a 35-kDa Carbonic Anhydrase IV in a Human Pancreatic Ductal Cell Line (Capan-1).
M. Fanjul, L. Alvarez, and E. Hollande (2007)
J. Histochem. Cytochem. 55, 783-794
   Abstract »    Full Text »    PDF »
Neural Cell Adhesion Molecule, a New Cytoadhesion Receptor for Plasmodium falciparum-Infected Erythrocytes Capable of Aggregation.
B. Pouvelle, V. Matarazzo, C. Jurzynski, J. Nemeth, M. Ramharter, G. Rougon, and J. Gysin (2007)
Infect. Immun. 75, 3516-3522
   Abstract »    Full Text »    PDF »
Structure and function of primitive immunoglobulin superfamily neural cell adhesion molecules: a lesson from studies on planarian.
E. Fusaoka, T. Inoue, K. Mineta, K. Agata, and K. Takeuchi (2006)
Genes Cells 11, 541-555
   Abstract »    Full Text »    PDF »
Specific Amino Acids in the First Fibronectin Type III Repeat of the Neural Cell Adhesion Molecule Play a Role in Its Recognition and Polysialylation by the Polysialyltransferase ST8Sia IV/PST.
S. S. Mendiratta, N. Sekulic, A. Lavie, and K. J. Colley (2005)
J. Biol. Chem. 280, 32340-32348
   Abstract »    Full Text »    PDF »
Adrenal Chromaffin Cells Exhibit Impaired Granule Trafficking in NCAM Knockout Mice.
S.-A. Chan, L. Polo-Parada, L. T. Landmesser, and C. Smith (2005)
J Neurophysiol 94, 1037-1047
   Abstract »    Full Text »    PDF »
Neural Cell Adhesion Molecule (N-CAM) Homophilic Binding Mediated by the Two N-terminal Ig Domains Is Influenced by Intramolecular Domain-Domain Interactions.
A. R. Atkins, W. J. Gallin, G. C. Owens, G. M. Edelman, and B. A. Cunningham (2004)
J. Biol. Chem. 279, 49633-49643
   Abstract »    Full Text »    PDF »
Extracellular Matrices of the Avian Ovarian Follicle: MOLECULAR CHARACTERIZATION OF CHICKEN PERLECAN.
S. Hummel, A. Osanger, T. M. Bajari, M. Balasubramani, W. Halfter, J. Nimpf, and W. J. Schneider (2004)
J. Biol. Chem. 279, 23486-23494
   Abstract »    Full Text »    PDF »
Mechanism of homophilic adhesion by the neural cell adhesion molecule: Use of multiple domains and flexibility.
C. P. Johnson, I. Fujimoto, C. Perrin-Tricaud, U. Rutishauser, and D. Leckband (2004)
PNAS 101, 6963-6968
   Abstract »    Full Text »    PDF »
Biochemistry and the Sciences of Recognition.
G. M. Edelman (2004)
J. Biol. Chem. 279, 7361-7369
   Full Text »    PDF »
Distinct Roles of Different Neural Cell Adhesion Molecule (NCAM) Isoforms in Synaptic Maturation Revealed by Analysis of NCAM 180 kDa Isoform-Deficient Mice.
L. Polo-Parada, C. M. Bose, F. Plattner, and L. T. Landmesser (2004)
J. Neurosci. 24, 1852-1864
   Abstract »    Full Text »    PDF »
Conditional Ablation of the Neural Cell Adhesion Molecule Reduces Precision of Spatial Learning, Long-Term Potentiation, and Depression in the CA1 Subfield of Mouse Hippocampus.
O. Bukalo, N. Fentrop, A. Y. W. Lee, B. Salmen, J. W. S. Law, C. T. Wotjak, M. Schweizer, A. Dityatev, and M. Schachner (2004)
J. Neurosci. 24, 1565-1577
   Abstract »    Full Text »    PDF »
Interaxonal Eph-Ephrin Signaling May Mediate Sorting of Olfactory Sensory Axons in Manduca sexta.
M. Kaneko and A. Nighorn (2003)
J. Neurosci. 23, 11523-11538
   Abstract »    Full Text »    PDF »
Polysialic Acid Directs Tumor Cell Growth by Controlling Heterophilic Neural Cell Adhesion Molecule Interactions.
R. Seidenfaden, A. Krauter, F. Schertzinger, R. Gerardy-Schahn, and H. Hildebrandt (2003)
Mol. Cell. Biol. 23, 5908-5918
   Abstract »    Full Text »    PDF »
Isolation of Definitive Zone and Chromaffin Cells Based upon Expression of CD56 (Neural Cell Adhesion Molecule) in the Human Fetal Adrenal Gland.
M. O. Muench, J. V. Ratcliffe, M. Nakanishi, H. Ishimoto, and R. B. Jaffe (2003)
J. Clin. Endocrinol. Metab. 88, 3921-3930
   Abstract »    Full Text »    PDF »
Dedifferentiation and Proliferation of Surviving Epithelial Cells in Acute Renal Failure.
J. V. Bonventre (2003)
J. Am. Soc. Nephrol. 14, S55-61
   Abstract »    Full Text »    PDF »
The molecular basis of cardiotropic viral infections.
W. Poller, H. Fechner, M. Noutsias, C. Tschoepe, M. Pauschinger, and H.-P. Schultheiss (2002)
Eur. Heart J. Suppl. 4, I18-I30
   Abstract »    PDF »
Fully Human Antibodies to MCAM/MUC18 Inhibit Tumor Growth and Metastasis of Human Melanoma.
L. Mills, C. Tellez, S. Huang, C. Baker, M. McCarty, L. Green, J. M. Gudas, X. Feng, and M. Bar-Eli (2002)
Cancer Res. 62, 5106-5114
   Abstract »    Full Text »    PDF »
PSA-NCAM Immunoreactivity in Chandelier Cell Axon Terminals of the Human Temporal Cortex.
J. I. Arellano, J. DeFelipe, and A. Munoz (2002)
Cereb Cortex 12, 617-624
   Abstract »    Full Text »    PDF »
Expression of CD56/Neural Cell Adhesion Molecule Correlates with the Presence of Lytic Bone Lesions in Multiple Myeloma and Distinguishes Myeloma from Monoclonal Gammopathy of Undetermined Significance and Lymphomas with Plasmacytoid Differentiation.
S. A. Ely and D. M. Knowles (2002)
Am. J. Pathol. 160, 1293-1299
   Abstract »    Full Text »    PDF »
The polysialyltransferase ST8Sia II/STX: posttranslational processing and role of autopolysialylation in the polysialylation of neural cell adhesion molecule.
B. E. Close, J. M. Wilkinson, T. J. Bohrer, C. P. Goodwin, L. J. Broom, and K. J. Colley (2001)
Glycobiology 11, 997-1008
   Abstract »    Full Text »    PDF »
Multiple cadherin extracellular repeats mediate homophilic binding and adhesion.
S. Chappuis-Flament, E. Wong, L. D. Hicks, C. M. Kay, and B. M. Gumbiner (2001)
J. Cell Biol. 154, 231-243
   Abstract »    Full Text »    PDF »
Loss of Caspase-8 Expression in Highly Malignant Human Neuroblastoma Cells Correlates with Resistance to Tumor Necrosis Factor-related Apoptosis-inducing Ligand-induced Apoptosis.
S. Hopkins-Donaldson, J.-L. Bodmer, K. B. Bourloud, C. B. Brognara, J. Tschopp, and N. Gross (2000)
Cancer Res. 60, 4315-4319
   Abstract »    Full Text »
Novel gene expressed in nasal region influences outgrowth of olfactory axons and migration of luteinizing hormone-releasing hormone (LHRH) neurons.
P.R. Kramer and S. Wray (2000)
Genes & Dev. 14, 1824-1834
   Abstract »    Full Text »
Expression of alpha 2,8/2,9-Polysialyltransferase from Escherichia coli K92. CHARACTERIZATION OF THE ENZYME AND ITS REACTION PRODUCTS.
G.-J. Shen, A. K. Datta, M. Izumi, K. M. Koeller, and C.-H. Wong (1999)
J. Biol. Chem. 274, 35139-35146
   Abstract »    Full Text »    PDF »
The Neural Cell Adhesion Molecules L1 and NCAM-180 Act in Different Steps of Neurite Outgrowth.
K. Takei, T. A. Chan, F.-S. Wang, H. Deng, U. Rutishauser, and D. G. Jay (1999)
J. Neurosci. 19, 9469-9479
   Abstract »    Full Text »    PDF »
Expression of NCAM recapitulates tubulogenic development in kidneys recovering from acute ischemia.
M. Abbate, D. Brown, and J. V. Bonventre (1999)
Am J Physiol Renal Physiol 277, F454-F463
   Abstract »    Full Text »    PDF »
Effects of Different Immunolabeling Techniques on the Detection of Small-cell Lung Cancer Cells in Bone Marrow.
G. Pelosi, F. Pasini, F. Pavanel, E. Bresaola, I. Schiavon, and A. Iannucci (1999)
J. Histochem. Cytochem. 47, 1075-1088
   Abstract »    Full Text »
Divergent Cellular Differentiation Pathways during the Invasive Stage of Cutaneous Malignant Melanoma Progression.
J. A. Reed, B. Finnerty, and A. P. Albino (1999)
Am. J. Pathol. 155, 549-555
   Abstract »    Full Text »    PDF »
Neural Cell Adhesion Molecule (N-CAM) Is Required for Cell Type Segregation and Normal Ultrastructure in Pancreatic Islets.
F. Esni, I.-B. Taljedal, A.-K. Perl, H. Cremer, G. Christofori, and H. Semb (1999)
J. Cell Biol. 144, 325-337
   Abstract »    Full Text »    PDF »
NF-kappa B Activity Is Induced by Neural Cell Adhesion Molecule Binding to Neurons and Astrocytes.
L. A. Krushel, B. A. Cunningham, G. M. Edelman, and K. L. Crossin (1999)
J. Biol. Chem. 274, 2432-2439
   Abstract »    Full Text »    PDF »
Distinct Patterns of NCAM Expression Are Associated with Defined Stages of Murine Hair Follicle Morphogenesis and Regression.
S. Müller–Röver, E. J. M. Peters, V. A. Botchkarev, A. Panteleyev, and R. Paus (1998)
J. Histochem. Cytochem. 46, 1401-1410
   Abstract »    Full Text »
The Second Catalytic Domain of Protein Tyrosine Phosphatase delta  (PTPdelta ) Binds to and Inhibits the First Catalytic Domain of PTPsigma.
M. J. Wallace, C. Fladd, J. Batt, and D. Rotin (1998)
Mol. Cell. Biol. 18, 2608-2616
   Abstract »    Full Text »
CD148 Is a Membrane Protein Tyrosine Phosphatase Present in All Hematopoietic Lineages and Is Involved in Signal Transduction on Lymphocytes.
M. A. de la Fuente-Garcia, J. M. Nicolas, J. H. Freed, E. Palou, A. P. Thomas, R. Vilella, J. Vives, and A. Gaya (1998)
Blood 91, 2800-2809
   Abstract »    Full Text »    PDF »
The Ig Superfamily Cell Adhesion Molecule, apCAM, Mediates Growth Cone Steering by Substrate-Cytoskeletal Coupling.
D. M. Suter, L. D. Errante, V. Belotserkovsky, and P. Forscher (1998)
J. Cell Biol. 141, 227-240
   Abstract »    Full Text »    PDF »
Neural cell adhesion molecule (N-CAM) domains and intracellular signaling pathways involved in the inhibition of astrocyte proliferation.
L. A. Krushel, M.-H. Tai, B. A. Cunningham, G. M. Edelman, and K. L. Crossin (1998)
PNAS 95, 2592-2596
   Abstract »    Full Text »    PDF »
The O-glycosylated Stalk Domain Is Required for Apical Sorting of Neurotrophin Receptors in Polarized MDCK Cells.
C. Yeaman, A. H. L. Gall, A. N. Baldwin, L. Monlauzeur, A. L. Bivic, and E. Rodriguez-Boulan (1997)
J. Cell Biol. 139, 929-940
   Abstract »    Full Text »    PDF »
Organization of the Neurofascin Gene and Analysis of Developmentally Regulated Alternative Splicing.
B. Hassel, F. G. Rathjen, and H. Volkmer (1997)
J. Biol. Chem. 272, 28742-28749
   Abstract »    Full Text »    PDF »
Identification of a Novel Neural Cell Adhesion Molecule-related Gene with a Potential Role in Selective Axonal Projection.
M. Alenius and S. Bohm (1997)
J. Biol. Chem. 272, 26083-26086
   Abstract »    Full Text »    PDF »
CD7+ and CD56+ Myeloid/Natural Killer Cell Precursor Acute Leukemia: A Distinct Hematolymphoid Disease Entity.
R. Suzuki, K. Yamamoto, M. Seto, Y. Kagami, M. Ogura, Y. Yatabe, T. Suchi, Y. Kodera, Y. Morishima, T. Takahashi, et al. (1997)
Blood 90, 2417-2428
   Abstract »    Full Text »    PDF »
Isoform-specific Interaction of the Myosin-binding Proteins (MyBPs) with Skeletal and Cardiac Myosin Is a Property of the C-terminal Immunoglobulin Domain.
T. N. Alyonycheva, T. Mikawa, F. C. Reinach, and D. A. Fischman (1997)
J. Biol. Chem. 272, 20866-20872
   Abstract »    Full Text »    PDF »
OCAM: A New Member of the Neural Cell Adhesion Molecule Family Related to Zone-to-Zone Projection of Olfactory and Vomeronasal Axons.
Y. Yoshihara, M. Kawasaki, A. Tamada, H. Fujita, H. Hayashi, H. Kagamiyama, and K. Mori (1997)
J. Neurosci. 17, 5830-5842
   Abstract »    Full Text »    PDF »
Differential Glycosylation of Tractin and LeechCAM, Two Novel Ig Superfamily Members, Regulates Neurite Extension and Fascicle Formation.
Y. Huang, J. Jellies, K. M. Johansen, and J. Johansen (1997)
J. Cell Biol. 138, 143-157
   Abstract »    Full Text »    PDF »
The First Immunoglobulin-like Neural Cell Adhesion Molecule (NCAM) Domain Is Involved in Double-reciprocal Interaction with the Second Immunoglobulin-like NCAM Domain and in Heparin Binding.
V. V. Kiselyov, V. Berezin, T. E. Maar, V. Soroka, K. Edvardsen, A. Schousboe, and E. Bock (1997)
J. Biol. Chem. 272, 10125-10134
   Abstract »    Full Text »    PDF »
NCAM140 Interacts with the Focal Adhesion Kinase p125fak and the SRC-related Tyrosine Kinase p59fyn.
H. E. Beggs, S. C. Baragona, J. J. Hemperly, and P. F. Maness (1997)
J. Biol. Chem. 272, 8310-8319
   Abstract »    Full Text »    PDF »
The Neural Cell Adhesion Molecule Expresses a Tyrosine-independent Basolateral Sorting Signal.
A. H. Le Gall, S. K. Powell, C. A. Yeaman, and E. Rodriguez-Boulan (1997)
J. Biol. Chem. 272, 4559-4567
   Abstract »    Full Text »    PDF »
klingon, a novel member of the Drosophila immunoglobulin superfamily, is required for the development of the R7 photoreceptor neuron.
S. Butler, S Ray, and Y Hiromi (1997)
Development 124, 781-792
   Abstract »    PDF »
The Many Faces of Fasciclin II: Genetic Analysis Reveals Multiple Roles for a Cell Adhesion Molecule during the Generation of Neuronal Specificity.
C.S. Goodman, G.W. Davis, and K. Zito (1997)
Cold Spring Harb Symp Quant Biol 62, 479-491
   Abstract »    PDF »
Characterization of the Major Core Structures of the alpha 2right-arrow 8-linked Polysialic Acid-containing Glycan Chains Present in Neural Cell Adhesion Molecule in Embryonic Chick Brains.
M. Kudo, K. Kitajima, S. Inoue, K. Shiokawa, H. R. Morris, A. Dell, and Y. Inoue (1996)
J. Biol. Chem. 271, 32667-32677
   Abstract »    Full Text »    PDF »
Identification of the Product of Growth Arrest-specific Gene 6as a Common Ligand for Axl, Sky, and Mer Receptor Tyrosine Kinases.
K. Nagata, K. Ohashi, T. Nakano, H. Arita, C. Zong, H. Hanafusa, and K. Mizuno (1996)
J. Biol. Chem. 271, 30022-30027
   Abstract »    Full Text »    PDF »
Elements of Neural Adhesion Molecules and a Yeast Vacuolar Protein Sorting Receptor Are Present in a Novel Mammalian Low Density Lipoprotein Receptor Family Member.
H. Yamazaki, H. Bujo, J. Kusunoki, K. Seimiya, T. Kanaki, N. Morisaki, W. J. Schneider, and Y. Saito (1996)
J. Biol. Chem. 271, 24761-24768
   Abstract »    Full Text »    PDF »
cDNA Cloning of a Novel Membrane Glycoprotein That Is Expressed Specifically in Glial Cells in the Mouse Brain. LIG-1, A PROTEIN WITH LEUCINE-RICH REPEATS AND IMMUNOGLOBULIN-LIKE DOMAINS.
Y. Suzuki, N. Sato, M. Tohyama, A. Wanaka, and T. Takagi (1996)
J. Biol. Chem. 271, 22522-22527
   Abstract »    Full Text »    PDF »
Expression and Functional Analysis of a Novel Isoform of Gicerin, an Immunoglobulin Superfamily Cell Adhesion Molecule.
E. Taira, T. Nagino, H. Taniura, N. Takaha, C.-H. Kim, C.-H. Kuo, B.-S. Li, H. Higuchi, and N. Miki (1995)
J. Biol. Chem. 270, 28681-28687
   Abstract »    Full Text »    PDF »
The Cytoplasmic Domain of the Drosophila Cell Adhesion Molecule Neuroglian Is Not Essential for Its Homophilic Adhesive Properties in S2 Cells.
M. Hortsch, Y.-m. E. Wang, Y. Marikar, and A. J. Bieber (1995)
J. Biol. Chem. 270, 18809-18817
   Abstract »    Full Text »    PDF »
Protein Determinants for Specific Polysialylation of the Neural Cell Adhesion Molecule.
R. W. Nelson, P. A. Bates, and U. Rutishauser (1995)
J. Biol. Chem. 270, 17171-17179
   Abstract »    Full Text »    PDF »
Molecular Cloning of Sia[IMAGE]2,3Gal[IMAGE]1,4GlcNAc [IMAGE]2,8-Sialyltransferase from Mouse Brain.
Y. Yoshida, N. Kojima, N. Kurosawa, T. Hamamoto, and S. Tsuji (1995)
J. Biol. Chem. 270, 14628-14633
   Abstract »    Full Text »    PDF »
The limbic system-associated membrane protein (LAMP) selectively mediates interactions with specific central neuron populations.
V Zhukareva and P Levitt (1995)
Development 121, 1161-1172
   Abstract »    PDF »
Liver-regulating protein (LRP) is a plasma membrane protein involved in cell contact-mediated regulation of Sertoli cell function by primary spermatocytes.
N Gerard, A Corlu, B Kneip, H Kercret, M Rissel, C Guguen-Guillouzo, and B Jegou (1995)
J. Cell Sci. 108, 917-925
   Abstract »    PDF »
Nuclear transport of the U2 snRNP-specific U2B'' protein is mediated by both direct and indirect signalling mechanisms.
C. Kambach and I. W. Mattaj (1994)
J. Cell Sci. 107, 1807-1816
   Abstract »    PDF »
The novel homeodomain gene buttonless specifies differentiation and axonal guidance functions of Drosophila dorsal median cells.
C Chiang, N. Patel, K. Young, and P. Beachy (1994)
Development 120, 3581-3593
   Abstract »    PDF »
Co-localization of 1,4-dihydropyridine receptor alpha 2/delta subunit and N-CAM during early myogenesis in vitro.
S. Vandaele and F Rieger (1994)
J. Cell Sci. 107, 1217-1227
   Abstract »    PDF »
Studies of the Deleted in Colorectal Cancer Gene in Normal and Neoplastic Tissues.
E.R. Fearon, B.C. Ekstrand, G. Hu, W.E. Pierceall, M.A. Reale, and S.H. Bigner (1994)
Cold Spring Harb Symp Quant Biol 59, 637-643
   Abstract »    PDF »
The irregular chiasm C-roughest locus of Drosophila, which affects axonal projections and programmed cell death, encodes a novel immunoglobulin-like protein..
R G Ramos, G L Igloi, B Lichte, U Baumann, D Maier, T Schneider, J H Brandstatter, A Frohlich, and K F Fischbach (1993)
Genes & Dev. 7, 2533-2547
   Abstract »    PDF »
Products of the unc-52 gene in Caenorhabditis elegans are homologous to the core protein of the mammalian basement membrane heparan sulfate proteoglycan..
T M Rogalski, B D Williams, G P Mullen, and D G Moerman (1993)
Genes & Dev. 7, 1471-1484
   Abstract »    PDF »
Specifying the path of the intersegmental nerve of the Drosophila embryo: a role for Delta and Notch.
E Giniger, L. Jan, and Y. Jan (1993)
Development 117, 431-440
   Abstract »    PDF »
Immortalization of polarized rat retinal pigment epithelium.
I. Nabi, A. Mathews, L Cohen-Gould, D Gundersen, and E Rodriguez-Boulan (1993)
J. Cell Sci. 104, 37-49
   Abstract »    PDF »
Modulation of an NCAM-related adhesion molecule with long-term synaptic plasticity in Aplysia.
M Mayford, A Barzilai, F Keller, S Schacher, and E. Kandel (1992)
Science 256, 638-644
   Abstract »    PDF »
The expression of tissue and urokinase-type plasminogen activators in neural development suggests different modes of proteolytic involvement in neuronal growth.
Y Sumi, M. Dent, D. Owen, P. Seeley, and R. Morris (1992)
Development 116, 625-637
   Abstract »    PDF »
A developmentally regulated switch in neuronal responsiveness to NCAM and N-cadherin in the rat hippocampus.
P Doherty, S. Skaper, S. Moore, A Leon, and F. Walsh (1992)
Development 115, 885-892
   Abstract »    PDF »
Mediation and Inhibition of Cell Adhesion by Morphoregulatory Molecules.
G.M. Edelman (1992)
Cold Spring Harb Symp Quant Biol 57, 317-325
   Abstract »    PDF »
Alternative splicing in the neural cell adhesion molecule pre-mRNA: regulation of exon 18 skipping depends on the 5'-splice site..
R Tacke and C Goridis (1991)
Genes & Dev. 5, 1416-1429
   Abstract »    PDF »
Protein tyrosine phosphatases: a diverse family of intracellular and transmembrane enzymes.
E. Fischer, H Charbonneau, and N. Tonks (1991)
Science 253, 401-406
   Abstract »    PDF »
Cadherin cell adhesion receptors as a morphogenetic regulator.
M Takeichi (1991)
Science 251, 1451-1455
   Abstract »    PDF »
Molecular analysis of protein assembly in muscle development.
H. Epstein and D. Fischman (1991)
Science 251, 1039-1044
   Abstract »    PDF »
PECAM-1 (CD31) cloning and relation to adhesion molecules of the immunoglobulin gene superfamily.
P. Newman, M. Berndt, J Gorski, G. White 2nd, S Lyman, C Paddock, and W. Muller (1990)
Science 247, 1219-1222
   Abstract »    PDF »
Identification of a chromosome 18q gene that is altered in colorectal cancers.
E. Fearon, K. Cho, J. Nigro, S. Kern, J. Simons, J. Ruppert, Hamilton SR, A. Preisinger, G Thomas, K. Kinzler, et al. (1990)
Science 247, 49-56
   Abstract »    PDF »
Place-dependent Cell Adhesion, Process Retraction, and Spatial Signaling in Neural Morphogenesis.
G.M. Edelman and B.A. Cunningham (1990)
Cold Spring Harb Symp Quant Biol 55, 303-318
   Abstract »    PDF »
Molecular Genetics of Neuronal Recognition in Drosophila: Evolution and Function of Immunoglobulin Superfamily Cell Adhesion Molecules.
G. Grenningloh, A.J. Bieber, E.J. Rehm, P.M. Snow, Z.R. Traquina, M. Hortsch, N.H. Patel, and C.S. Goodman (1990)
Cold Spring Harb Symp Quant Biol 55, 327-340
   Abstract »    PDF »
Mechanisms for regulating expression of membrane isoforms of Fc gamma RIII (CD16).
M. Hibbs, P Selvaraj, O Carpen, T. Springer, H Kuster, M. Jouvin, and J. Kinet (1989)
Science 246, 1608-1611
   Abstract »    PDF »
Signal transduction by the platelet-derived growth factor receptor.
L. Williams (1989)
Science 243, 1564-1570
   Abstract »    PDF »
Alternative splicing of the neural cell adhesion molecule gene generates variant extracellular domain structure in skeletal muscle and brain..
J Thompson, G Dickson, S E Moore, H J Gower, W Putt, J G Kenimer, C H Barton, and F S Walsh (1989)
Genes & Dev. 3, 348-357
   Abstract »    PDF »
Interleukin-6 Receptor and a Unique Mechanism of Its Signal Transduction.
T. Taga, M. Hibi, Y. Hirata, H. Yawata, S. Natsuka, K. Yasukawa, T. Totsuka, K. Yamasaki, T. Hirano, and T. Kishimoto (1989)
Cold Spring Harb Symp Quant Biol 54, 713-722
   Abstract »    PDF »
Axon guidance and the patterning of neuronal projections in vertebrates.
J Dodd and T. Jessell (1988)
Science 242, 692-699
   Abstract »    PDF »
Growth cone guidance in insects: fasciclin II is a member of the immunoglobulin superfamily.
A. Harrelson and C. Goodman (1988)
Science 242, 700-708
   Abstract »    PDF »
Chemical Analysis of the Developmental Pattern of Polysialylation in Chicken Brain. EXPRESSION OF ONLY AN EXTENDED FORM OF POLYSIALYL CHAINS DURING EMBRYOGENESIS AND THE PRESENCE OF DISIALYL RESIDUES IN BOTH EMBRYONIC AND ADULT CHICKEN BRAINS.
S. Inoue, S.-L. Lin, and Y. Inoue (2000)
J. Biol. Chem. 275, 29968-29979
   Abstract »    Full Text »    PDF »
Molecular Cloning of a Dendritic Cell-associated Transmembrane Protein, DC-HIL, That Promotes RGD-dependent Adhesion of Endothelial Cells through Recognition of Heparan Sulfate Proteoglycans.
S. Shikano, M. Bonkobara, P. K. Zukas, and K. Ariizumi (2001)
J. Biol. Chem. 276, 8125-8134
   Abstract »    Full Text »    PDF »
Differential Biosynthesis of Polysialic or Disialic Acid Structure by ST8Sia II and ST8Sia IV.
S. Kitazume-Kawaguchi, S. Kabata, and M. Arita (2001)
J. Biol. Chem. 276, 15696-15703
   Abstract »    Full Text »    PDF »
A short segment within the cytoplasmic domain of the neural cell adhesion molecule (N-CAM) is essential for N-CAM-induced NF-kappa B activity in astrocytes.
E. B. Little, K. L. Crossin, L. A. Krushel, G. M. Edelman, and B. A. Cunningham (2001)
PNAS 98, 2238-2243
   Abstract »    Full Text »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)