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Science 10 April 1987:
Vol. 236. no. 4798, pp. 193 - 197
DOI: 10.1126/science.3563497
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Articles

Science, Vol 236, Issue 4798, 193-197
Copyright © 1987 by American Association for the Advancement of Science

articles

Cellular localization of somatomedin (insulin-like growth factor) messenger RNA in the human fetus

VK Han, AJ D'Ercole, and PK Lund

The somatomedins or insulin-like growth factors (IGFs) are synthesized in many organs and tissues, but the specific cells that synthesize them in vivo have not been defined. By in situ hybridization histochemistry, IGF I (somatomedin C) and IGF II messenger RNAs were localized to connective tissues or cells of mesenchymal origin in 14 organs and tissues from human fetuses. IGF messenger RNAs were localized to perisinusoidal cells of liver, to perichondrium of cartilage, to sclera of eye, and to connective tissue layers, sheaths, septa, and capsules of each organ and tissue. All of the hybridizing regions are comprised predominantly of fibroblasts or other cells of mesenchymal origin. Because these cells are widely distributed and anatomically integrated into tissues and organs, they are ideally located for production of IGFs, which may exert paracrine effects on nearby target cells.


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