Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Site Tools

  • AAAS
  • Subscribe
  • Feedback

Site Search

Search Advanced

Science 3 April 1987:
Vol. 236. no. 4797, pp. 92 - 94
DOI: 10.1126/science.3470945
Prev | Table of Contents | Next

Articles

Science, Vol 236, Issue 4797, 92-94
Copyright © 1987 by American Association for the Advancement of Science

articles

Fragile sites at 16q22 are not at the breakpoint of the chromosomal rearrangement in AMMoL

RN Simmers, GR Sutherland, A West, and RI Richards

There is much speculation about fragile sites on human chromosomes predisposing to specific chromosome rearrangements seen in cancer. Acute myelomonocytic leukemia is characterized by neoplastic chromosome rearrangements involving band 16q22 in patients who carry the rare fragile site at 16q22. This specific leukemic breakpoint is within the metallothionein gene cluster, which is here shown to be proximal to the rare fragile site (FRA16B) and to a common fragile site (FRA16C) in this region. Hence neither of these fragile sites are at the breakpoint in this leukemic chromosomal rearrangement.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Chromosomal Fragile Site FRA16D and DNA Instability in Cancer.
M. Mangelsdorf, K. Ried, E. Woollatt, S. Dayan, H. Eyre, M. Finnis, L. Hobson, J. Nancarrow, D. Venter, E. Baker, et al. (2000)
Cancer Res. 60, 1683-1689
   Abstract »    Full Text »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)